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Inorganics
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Selective Synthesis of New Organometallic and Organochalcogen Compounds Based on...
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Selective Synthesis of New Organometallic and Organochalcogen Compounds Based on Inorganic Reagents

A special issue of Inorganics (ISSN 2304-6740). This special issue belongs to the section "Organometallic Chemistry".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 3839

Special Issue Editors

Dr. Maria V. Musalova

E-Mail Website
Guest Editor
Siberian Division of The Russian Academy of Sciences, A. E. Favorsky Irkutsk Institute of Chemistry, 1 Favorsky Str., 664033 Irkutsk, Russia
Interests: organotellurium compounds; tellurium tetrachloride; diorganyl tellanes, organochalcogen compounds; heterocyclic compounds; tellurium tetrabromide, organometallic compounds; addition reactions
Dr. Maxim V. Musalov

E-Mail Website
Guest Editor
A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Division of the Russian Academy of Sciences, 1 Favorsky Str., 664033 Irkutsk, Russia
Interests: organometallic compounds; selenium; tellurium; unsaturated organochalcogen compounds; heterocyclic compounds; functionalization; chalcogen annelation reactions
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Inorganic reagents, if efficient and selective, often play a crucial role in modern organic synthesis. The application of novel efficient and selective inorganic reagents in organic synthesis has made a significant contribution to many fields of chemical sciences. The investigation of chemical properties of inorganic reagents is a very important area of research, which makes it possible to obtain a variety of new valuable products.

Over the past few decades, a number of new effective and selective inorganic reagents have been introduced into organic synthesis. For example, selenium dihalides, introduced into organic synthesis at the beginning of this century, are now widely used for the preparation of functionalized organoselenium compounds including selenium heterocycles.

The Special Issue will focus on recent developments in regio- and stereoselective synthesis of new organometallic and organochalcogen compounds based on inorganic reagents. This Special Issue welcomes original research and review articles covering various aspects of organometallic and organochalcogen chemistry, including synthesis, reactivity, structural studies, and applications. Special attention will be paid to the development of breakthrough synthetic approaches and methodologies that allow regio- and stereoselective synthesis of novel products of practical importance.

Dr. Maria V. Musalova
Dr. Maxim V. Musalov
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Inorganics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • organometallic compounds
  • inorganic reagents
  • addition reactions
  • regioselective synthesis
  • selenium dihalides
  • tellurium tetrahalides
  • stereoselective synthesis

Published Papers (3 papers)

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Research

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15 pages, 3724 KiB  
Article
Transannular Selenocyclofunctionalization of 1,5-cyclooctadiene: The Antioxidant Properties of 9-selenabicyclo[3.3.1]nonane Derivatives and the Discovery of Increasing Both GPx and GR Activities
by Maxim V. Musalov, Irina S. Kapustina, Ekaterina V. Spiridonova, Natalya V. Ozolina, Svetlana V. Amosova, Tatyana N. Borodina and Vladimir A. Potapov
Inorganics 2023, 11(7), 304; https://doi.org/10.3390/inorganics11070304 - 15 Jul 2023
Cited by 3 | Viewed by 1069
Abstract
Oxidative stress is the cause of various pathologies and disorders of cellular functions. Substances that reduce the pathological effect of oxidative stress on homeostasis include organoselenium compounds of natural and synthetic origin. Depending on the structure, organoselenium compounds can exhibit different biological activities, [...] Read more.
Oxidative stress is the cause of various pathologies and disorders of cellular functions. Substances that reduce the pathological effect of oxidative stress on homeostasis include organoselenium compounds of natural and synthetic origin. Depending on the structure, organoselenium compounds can exhibit different biological activities, for example, reducing oxidative stress, participating in the regulation of signaling systems, influencing the synthesis of cytokines, etc. This makes them promising products for the development of new means of metabolic correction and drugs with enzyme-like activity. This study is aimed at developing an effective method for the synthesis of functional organoselenium compounds and studying their antioxidant effect in vivo under stress conditions. A one-pot catalyst-free method of transannular addition-functionalization of cis,cis-1,5-cyclooctadiene with selenium dihalides in the presence of nucleophiles was developed. For the first time, the antioxidant activity of functionalized 9-selenabicyclo[3.3.1]nonanes was studied in vivo. Quantitative characteristics of the effect on the level of lipid peroxidation and the activity of glutathione peroxidase and glutathione reductase under stress conditions were obtained. The effect of substituents in the selenium-containing scaffold on the biological activity of the compounds was studied. The water-soluble 9-selenabicyclo[3.3.1]nonane derivatives, containing hydroxyl and 2-hydroxyethoxy groups, which increased the activity of both glutathione peroxidase and glutathione reductase, were discovered. Full article
(This article belongs to the Special Issue Selective Synthesis of New Organometallic and Organochalcogen Compounds Based on Inorganic Reagents)
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18 pages, 5046 KiB  
Article
Green Organoselenium Chemistry: Selective Syntheses of New 1,4-Thiaselenine Derivatives Based on Reactions of Thiaselenole Reagent with Alcohols and Water
by Svetlana V. Amosova, Andrey S. Filippov, Nataliya A. Makhaeva, Alexander I. Albanov and Vladimir A. Potapov
Inorganics 2023, 11(7), 281; https://doi.org/10.3390/inorganics11070281 - 29 Jun 2023
Cited by 1 | Viewed by 651
Abstract
Environmentally friendly synthetic methods were developed for the selective preparation of new 2,3-dihydro-1,4-thiaselenine derivatives in high yields based on the reactions of 2-bromomethyl-1,3-thiaselenole with alcohols and water at room temperature. The reaction of 2-bromomethyl-1,3-thiaselenole with alcohols was accompanied by a rearrangement with ring [...] Read more.
Environmentally friendly synthetic methods were developed for the selective preparation of new 2,3-dihydro-1,4-thiaselenine derivatives in high yields based on the reactions of 2-bromomethyl-1,3-thiaselenole with alcohols and water at room temperature. The reaction of 2-bromomethyl-1,3-thiaselenole with alcohols was accompanied by a rearrangement with ring extension, leading to six-membered heterocyclic compounds, a new family of 2-organyloxy-2,3-dihydro-1,4-thiaselenines, in 80–96% yields. The remarkable cascade reactions of 2-bromomethyl-1,3-thiaselenole with water afforded 2,3-dihydro-1,4-thiaselenines functionalized with the (Z)-S-CH=CH-Se fragment and one or two highly reactive aldehyde groups. The latter aldehydes were functionalized by the reactions with alcohols and glycols to give new polyfunctionalized compounds, containing two double bonds, two sulfur atoms, two selenium atoms, and two or four oxygen atoms, in high yields. Full article
(This article belongs to the Special Issue Selective Synthesis of New Organometallic and Organochalcogen Compounds Based on Inorganic Reagents)
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Review

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37 pages, 14349 KiB  
Review
Elemental Selenium in the Synthesis of Selenaheterocycles
by Alexander V. Martynov
Inorganics 2023, 11(7), 287; https://doi.org/10.3390/inorganics11070287 - 2 Jul 2023
Cited by 2 | Viewed by 1813
Abstract
An overview of the known methods of introducing selenium under the action of elemental selenium into the structures of various saturated, unsaturated, and heteroaromatic selenacycles containing C–Se, N–Se, B–Se, Ge–Se and P–Se bonds is presented. These methods include metal, iodine, bromine or chlorine [...] Read more.
An overview of the known methods of introducing selenium under the action of elemental selenium into the structures of various saturated, unsaturated, and heteroaromatic selenacycles containing C–Se, N–Se, B–Se, Ge–Se and P–Se bonds is presented. These methods include metal, iodine, bromine or chlorine exchange for selenium and the direct cyclization of 1-(2-bromoaryl)benzimidazoles, polyunsaturated hydrocarbons, acetylenes, propargylic amines, 3-halogenaryl amides, aryl amides, diazo-compounds, 2-aminoacetophenone, and the annulation of ethynyl arenes. Three- and four-component reactions utilizing elemental selenium as one of the components and leading to selenium-containing heterocycles are presented as well. Full article
(This article belongs to the Special Issue Selective Synthesis of New Organometallic and Organochalcogen Compounds Based on Inorganic Reagents)
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