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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Pesticide Molecular Modeling: From Properties to Toxicology

edited by

Jean-Yves Le Questel

submission deadline 24 Jun 2025 | Viewed by 155 | Submission Open

Keywords: pesticide; three dimensional structure; molecular docking; molecular dynamics; quantum mechanics; homology modeling; pesticide target interactions; toxicity

(This special issue belongs to the Section Molecular Biophysics)

Urinary Titin: A Novel Biomarker for Muscle Atrophy and Catabolic Conditions

edited by Hiroshi Sakaue

submission deadline 25 Jun 2025 | 1 articles | Viewed by 970 | Submission Open

Keywords: urinary titin; skeletal muscle; muscle atrophy; sarcopenia; biomarker; catabolism; inflammation

(This special issue belongs to the Section Molecular Biology)

Red Blood Cells in Health and Disease

edited by Annamaria Russo and Ester Tellone

submission deadline 25 Jun 2025 | Viewed by 371 | Submission Open

Keywords: oxidative stress; metabolism; hemoglobin; erythrocytes

(This special issue belongs to the Section Biochemistry)

Protection of Natural Products in Liver Injury

edited by

Jeon-Ok Moon

submission deadline 27 Jun 2025 | Viewed by 111 | Submission Open

Keywords: liver injury; natural product; antioxidant activity; modulation of inflammatory pathway; mitigation of fibrosis; pharmacology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Breeding for Abiotic Stress Tolerance in Crops (Second Edition)

edited by

Mario A. Pagnotta

submission deadline 28 Jun 2025 | 1 articles | Viewed by 1486 | Submission Open

Keywords: plant breeding; advance molecular approach; molecular characterization; environmental stresses plant tolerance; resistant genes; QTLs; drought; salinity; climatic changes

(This special issue belongs to the Section Molecular Plant Sciences)

Mechanistic Insights, Therapeutic Potential, and Applications of Natural Bioactive Compounds

edited by

Jianqiang Xu

and

Yanshuo Han

submission deadline 28 Jun 2025 | 1 articles | Viewed by 843 | Submission Open

Keywords: oxidative stress; inflammation; chronic diseases; natural bioactive compounds; plant-derived molecules; redox homeostasis; anti-inflammatory mechanisms; antioxidant activity; drug discovery; synergistic effects; combination therapies

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Urologic Cancers: Molecular Basis for Novel Therapeutic Approaches

edited by

Whi-An Kwon

submission deadline 28 Jun 2025 | Viewed by 159 | Submission Open

Keywords: urologic cancers; prostate cancer; urothelial cancer; renal cell cancer; genomics; proteomics; biomarkers; molecular pathways

(This special issue belongs to the Section Molecular Oncology)

Exploring the Molecular, Physiological, and Biochemical Responses of Crops to Stress

edited by

Hakim Manghwar

submission deadline 29 Jun 2025 | 4 articles | Viewed by 2800 | Submission Open

Keywords: molecular signaling pathways in response to biotic stresses (e.g.; bacteria; viruses; fungi; and insects); plant responses to abiotic stresses (e.g.; salinity; cold; drought; waterlogging; heat; heavy metals; and UV light); mechanisms of stress adaptation and tolerance; stress adaptation

(This special issue belongs to the Section Molecular Plant Sciences)

Development and Validation of New Analytical Methods for the Determination of Drugs and Their Metabolites

edited by

Anna Petruczynik

submission deadline 29 Jun 2025 | 1 articles | Viewed by 612 | Submission Open

Keywords: drugs; drug formulations; pharmacokinetics; metabolism studies; analytical techniques

(This special issue belongs to the Section Molecular Pharmacology)

Cellular Mechanisms and Signaling Pathways in Normal Tissue Repair and Fibrosis

edited by

Regina M. Day

and Jeffrey R. Koenitzer

submission deadline 29 Jun 2025 | 1 articles | Viewed by 147 | Submission Open

Keywords: fibrosis; inflammation; senescence; myofibroblasts; Wnt/hedgehog; extracellular matrix; hedgehog; angiotensin II/transforming growth factor-beta; ephrins

(This special issue belongs to the Section Molecular Biology)

Rare Diseases and Neuroscience

edited by

Michelangelo Mancuso

and

Filippo Drago

submission deadline 30 Jun 2025 | 8 articles | Viewed by 19911 | Submission Open

Keywords: neurogenetics; rare diseases; rare neurological diseases; cerebellar ataxia; rare movement disorders; mitochondrial diseases; innovative treatments in rare neurological diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genetics and Novel Techniques for Soybean Pivotal Characters

edited by

Qingshan Chen

and

Dawei Xin

submission deadline 30 Jun 2025 | 10 articles | Viewed by 19354 | Submission Open

Keywords: QTL mapping and marker-assisted selection; GWAS and genomic selection/prediction; molecular breeding by design; germplasm application; domestication and selection signatures; genotype x environment interaction; improvement of seed quality and/or nutritional quality traits; nitrogen efficiency modification; symbiosis mechanism detection; breeding for tolerance to biotic stresses; soybean– pathogen interaction; increasing the adaptation to the environment

(This special issue belongs to the Section Molecular Plant Sciences)

G Protein-Coupled Receptors

edited by

Dorota Latek

submission deadline 30 Jun 2025 | 7 articles | Viewed by 18952 | Submission Open

Keywords: biased signaling; activation microswitches; allosteric ligands; drug design; GPCR-targeted assays; compound profiling; orphan receptors; viral hijacking of GPCRs; cellular response; live-cell imaging

(This special issue belongs to the Section Molecular Biology)

State-of-the-Art Molecular Neurobiology in Poland

edited by

Irena Nalepa

submission deadline 30 Jun 2025 | 6 articles | Viewed by 18423 | Submission Open

Keywords: neurobiology; neurochemistry; neuropathology; neurophysiology; neuropharmacology; neurogenetics; neurodegeneration; aging neuroscience; neurogenesis; neuroplasticity; signalling pathways; signalling networks; systems biology; stress-related processes

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insight into Retinal Diseases

edited by Hsiaoming Chao, Robert Casson and Hsi-Kung Kuo

submission deadline 30 Jun 2025 | 8 articles | Viewed by 17707 | Submission Open

Keywords: faricimab; modified cerebrolysin; acupuncture; stem cells; gene therapy; retinal chip; femtosecond; artisan aphakia; artiflex; exozyme; silicon oil; amniotic membrane; EOG; multifocal ERG; flash ERG; VEP; microperimetry; OCT-A

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Current Molecular Science of Fragile X Syndrome and Associated Disorders

edited by Flora Tassone and Randi Hagerman

submission deadline 30 Jun 2025 | 12 articles | Viewed by 14022 | Submission Open

Keywords: FMR1; fragile X syndrome; FXPOI; FXTAS; FXAND; FXPAC; molecular studies

(This special issue belongs to the Section Molecular Biology)

Plant Omics: Sensing, Signaling, Regulation and Homeostasis

edited by

Margherita-Gabriella De Biasi

submission deadline 30 Jun 2025 | 5 articles | Viewed by 11163 | Submission Open

Keywords: plant homeostasis; omics; transcriptomics; metabolomics; proteomics; genomics; ionomics; environmental stress; regulatory mechanisms; metabolic processes; systems biology

(This special issue belongs to the Section Molecular Plant Sciences)

Breast Cancer: Molecular Pathology, Diagnosis, and Therapeutic Strategies

edited by Rodrigo Sánchez-Bayona

submission deadline 30 Jun 2025 | 5 articles | Viewed by 11102 | Submission Open

Keywords: biomarker; breast; molecular assays; molecular characterization; molecular-driven treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel MSC Perspectives: From Cell Regulation to Tissue Regeneration 4.0

edited by

Alessandra Pelagalli

and

Heba Abdelrazik

submission deadline 30 Jun 2025 | 5 articles | Viewed by 9440 | Submission Open

Keywords: mesenchymal stem cells (MSCs); regenerative medicine; tissue engineering; tissue repair; cell differentiation; cell behaviour and cell fate; traslational medicine; animal sources; MSC vesicles; MSC secretome; MSCs as genetic vectors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Understanding the Genetics of Complex Traits in Plants: Association Analysis and Genomic Selection Methods

edited by

Wenxin Liu

submission deadline 30 Jun 2025 | 9 articles | Viewed by 8761 | Submission Open

Keywords: association analysis; genomic selection; plant; complex trait; genetic architecture; molecular biology; molecular breeding; genotype– environment interaction

(This special issue belongs to the Section Molecular Plant Sciences)

Mechanisms of Heavy Metal Toxicity: 3rd Edition

edited by

Toshiyuki Kaji

submission deadline 30 Jun 2025 | 6 articles | Viewed by 8580 | Submission Open

Keywords: heavy metal; metal compound; metallothionein; cellular defense mechanism; metal transporter

(This special issue belongs to the Section Molecular Toxicology)

Synthesis, Characterization and Phyto-Function of Nanophotocatalysts

edited by

Maria G. P. M. S. Neves

Carla Isabel Madeira dos Santos

and

Nuno M. M. Moura

submission deadline 30 Jun 2025 | 4 articles | Viewed by 8294 | Submission Open

Keywords: nanophotocatalysts; green synthesis; hydrogen generation; pollutants; fine chemistry; photoinactivation; cancer; microorganisms

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Structure and Function of Intermediate Filaments in Health and Disease

edited by

Cecilia Bucci

Roberta Romano

and

Flora Guerra

submission deadline 30 Jun 2025 | 4 articles | Viewed by 7783 | Submission Open

Keywords: intermediate filaments; vimentin; peripherin; lamins; keratins; neurofilaments; mechanics; migration; signaling; autophagy; organelle positioning; organelle function; inflammation; neurodegenerative diseases; cancer; gene expression; epigenetics; post-translational modifications

(This special issue belongs to the Section Molecular Biology)

The Role of Lipids in Health and Diseases

edited by

Yutang Wang

submission deadline 30 Jun 2025 | 3 articles | Viewed by 7515 | Submission Open

Keywords: lipids; triglycerides; phospholipids; cholesterol; sphingolipids; steroids; fatty acids; lipid metabolism

(This special issue belongs to the Section Biochemistry)

RNA Biology and Regulation

edited by

Naoyuki Kataoka

submission deadline 30 Jun 2025 | 6 articles | Viewed by 7252 | Submission Open

Keywords: RNA processing; RNA transport; RNA localization; RNA editing; RNA synthesis; RNA stability; RNA modification; translation; transcription; RNA metabolism; human diseases

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Insights into Glioblastoma Pathogenesis: Focus on Progenitor Cells, Microglia and Noncoding RNA

edited by

Imran Khan

submission deadline 30 Jun 2025 | 2 articles | Viewed by 6481 | Submission Open

Keywords: glioblastoma; tumor microenvironment; microglia; tumor-infiltrating lymphocytes; astrocytes; progenitor cells; driver mutations

(This special issue belongs to the Section Molecular Oncology)

Potential Prevention and Treatment of Neurodegenerative Disorders

edited by

Maria Paola Bertuccio

submission deadline 30 Jun 2025 | 4 articles | Viewed by 6199 | Submission Open

Keywords: neurodegenerative disorders; molecular biomarkers; oxidative stress; therapeutic strategies; disease prevention

(This special issue belongs to the Section Molecular Neurobiology)

Multifunctional Application of Biopolymers and Biomaterials 2.0

edited by

Valentina Siracusa

submission deadline 30 Jun 2025 | 4 articles | Viewed by 5748 | Submission Open

Keywords: biopolymers; nanomaterials; biomaterials; functional materials; bioactive natural compounds; essential oil emulsion; natural colorant; plant extract; bioactive compounds; nanocomposite; functional composite; composite film and coatings

(This special issue belongs to the Section Materials Science)

Editorial Board Members’ Collection Series: “Bacterial Enzymes as Targets”

edited by

Clemente Capasso

and

Alicja Wegrzyn

submission deadline 30 Jun 2025 | 4 articles | Viewed by 5378 | Submission Open

Keywords: enzymes; cell wall biosynthesis; DNA replication; metabolic pathway; vital bacterial function; enzyme inhibition; antibacterial agents; antibiotic resistance

(This special issue belongs to the Section Biochemistry)

Protein Aggregation and Proteinopathies

edited by Hongyu Hu

submission deadline 30 Jun 2025 | 2 articles | Viewed by 4556 | Submission Open

Keywords: protein aggregation; inclusion; sequestration; interaction; phase transition; proteostasis; proteinopathy

(This special issue belongs to the Section Molecular Biology)

Molecular Studies of Natural Compounds and Plant Extracts—3rd Edition

edited by

Hsinjung Ho

submission deadline 30 Jun 2025 | 4 articles | Viewed by 3709 | Submission Open

Keywords: bioactive substances; plant chemistry; polysaccharides; flavonoids; alkaloids; saponins; terpenes; phenolic acids; volatile oils; antioxidant/anti-inflammatory/anti-cancer; blood pressure lowering; blood sugar lowering; antibacterial; antiviral; antiallergic

(This special issue belongs to the Section Biochemistry)

Metal Oxide Nanomaterial Properties: Molecular Electrochemistry and Biomedical Applications

edited by

Carmen Lǎzǎu

and

Cornelia Bandas

submission deadline 30 Jun 2025 | 2 articles | Viewed by 3189 | Submission Open

Keywords: inorganic binding biomolecules; nanostructured materials; metal oxide nanoparticles; metal oxide– polymer nanocomposites; active surface sites

(This special issue belongs to the Section Materials Science)

Synthesis and Applications of Photoactive Molecules and Photovoltaic Materials

edited by

Leandro M. O. Lourenço

and

Carlos Monteiro

submission deadline 30 Jun 2025 | 2 articles | Viewed by 3148 | Submission Open

Keywords: photochemistry; chromophores; light-activated systems; donor– acceptor structures; covalent and noncovalent chemistry; solar cells

(This special issue belongs to the Section Materials Science)

Fabrication and Application of Photocatalytically Active Materials

edited by

Imre Miklós Szilágyi

submission deadline 30 Jun 2025 | 2 articles | Viewed by 3007 | Submission Open

Keywords: semiconductor oxides; photocatalysis; materials science; nanotechnology; activity; catalyst preparation; nanomaterials; environmental applications

(This special issue belongs to the Section Materials Science)

Neuroinflammation: Advancements in Pathophysiology and Therapies (2nd Edition)

edited by

David Martín-Hernández

submission deadline 30 Jun 2025 | 2 articles | Viewed by 2895 | Submission Open

Keywords: neuroinflammation; CNS diseases; pathophysiology; therapeutic strategies; pharmacological treatments; neurological disorders; neurodegenerative diseases; cardiovascular diseases; psychiatric disorders

(This special issue belongs to the Section Molecular Neurobiology)

Plant and Environmental Interactions (Abiotic Stress)

edited by

Lixin Li

submission deadline 30 Jun 2025 | 4 articles | Viewed by 2454 | Submission Open

Keywords: stress response; signal transduction; metabolism and secondary metabolism; material/vesicle transportation; rhizospheric microorganism; interactions between plants and microorganisms

(This special issue belongs to the Section Molecular Plant Sciences)

Biomarker Discovery and Validation for Precision Oncology

edited by

Luís Lima

submission deadline 30 Jun 2025 | 4 articles | Viewed by 2228 | Submission Open

Keywords: biomarker discovery; biomarker validation; precision oncology; cancer screening; cancer diagnostics; liquid biopsy; multi-omics integration; targeted therapies; immunotherapy biomarkers; translational cancer research

(This special issue belongs to the Section Molecular Oncology)

Translational Research in Ophthalmic Pathology

edited by

Robert M. Verdijk

submission deadline 30 Jun 2025 | 1 articles | Viewed by 2228 | Submission Open

Keywords: eye; ophthalmology; immunohistochemistry; molecular biology; pathophysiology; translational science; anatomy; histology; pathology; orbit

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Imaging for Cancer Theranostics

edited by

Hak Soo Choi

and Kai Bao

submission deadline 30 Jun 2025 | 2 articles | Viewed by 2152 | Submission Open

Keywords: molecular imaging; cancer theranostics; precision medicine; targeted therapy; diagnostic imaging; theranostic agents; multimodal imaging; molecular probes

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Nanocrystals, Nanoclusters, Nanoparticles: Synthesis and Optical Properties

edited by

Sebastian Maćkowski

submission deadline 30 Jun 2025 | 2 articles | Viewed by 1964 | Submission Open

Keywords: nanocrystals; nanoclusters; nanoparticles; synthesis; optical properties

(This special issue belongs to the Section Molecular Nanoscience)

Multiple Sclerosis: From Molecular Pathology to Novel Therapeutic Approaches

edited by

László Vécsei

and

Masaru Tanaka

submission deadline 30 Jun 2025 | 3 articles | Viewed by 1913 | Submission Open

Keywords: progression-independent relapses (PIRAs); smouldering-associated worsening (SAW); lack of new relapses and of new magnetic resonance imaging activity (NEIDA); slowly expanding lesions (SEL); no evidence of smouldering disease activity (NESDA); neurofilament (NfL); glial fibrillary acidic protein (GFAP); patient-reported outcome (PRO); paramagnetic rim lesions (PRLs); relapse-associated worsening (RAW)

(This special issue belongs to the Section Molecular Neurobiology)

New Research Insights in Cystic Fibrosis and CFTR-Related Diseases

edited by Judith A. Coppinger

submission deadline 30 Jun 2025 | 2 articles | Viewed by 1639 | Submission Open

Keywords: cystic fibrosis; CFTR related diseases; COPD; immune cells; extracellular vesicles; neutrophils; therapeutics; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Oxidative Stress and Autophagy in Cancer Cells

edited by

Abdelhabib Semlali

submission deadline 30 Jun 2025 | 1 articles | Viewed by 1501 | Submission Open

Keywords: oxidative stress; autophagy; apoptosis; cancer cells; cancer cell signaling pathways

(This special issue belongs to the Section Molecular Biology)

Advances in Algae Molecular Biology and Biotechnology

edited by

Paolo Gualtieri

and

Laura Barsanti

submission deadline 30 Jun 2025 | Viewed by 1388 | Submission Open

Keywords: molecular techniques; microscopy; microspectrophotometry; molecular biology and phylogenetics; processing and pattern recognition in alga images; molecular processes in photoreception; nutraceuticals and functional food production; toxicity; bioremediation; industrial exploitation; health care importance; environmental sustainability

(This special issue belongs to the Section Molecular Plant Sciences)

Eye Diseases: From Pathophysiology to Novel Therapeutic Approaches

edited by

Tomasz Chorągiewicz

and

Joanna Dolar-Szczasny

submission deadline 30 Jun 2025 | 2 articles | Viewed by 1366 | Submission Open

Keywords: eye diseases; genetic; biochemical; proteomic; cellular and physiological level; innovative therapeutic approaches

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Developmental Biology: Computational and Experimental Approaches, 2nd Edition

edited by

Mikhail P. Ponomarenko

submission deadline 30 Jun 2025 | 4 articles | Viewed by 1274 | Submission Open

Keywords: animal; plant; fungus; biological organization hierarchy; evolutionary limitations

(This special issue belongs to the Section Molecular Biology)

Brain-Body Interactions in Mental Disorders: Molecular Mechanisms and Therapeutics

edited by Yan-Xue Xue

submission deadline 30 Jun 2025 | 1 articles | Viewed by 1206 | Submission Open

Keywords: mental disorders; brain– body interactions; neural mechanisms; therapeutics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances and Insights in Cancer Genomics

edited by

Masa Tsuchiya

Alessandro Giuliani

and

Kenichi Yoshikawa

submission deadline 30 Jun 2025 | 1 articles | Viewed by 1194 | Submission Open

Keywords: biochemistry; biophysics; cancer genomics; cell biology; complex networks; complex systems; data science; development and differentiation; epigenomics; genome computing; higher-order structure of chromatin; multi-omics integration; next-generation sequencing; proteomics; single-cell CRISPR screens; single-cell genomics; transcriptomics; tumor biology

(This special issue belongs to the Section Molecular Oncology)

Genomics of Human Disease

edited by

Sungkyoung Choi

submission deadline 30 Jun 2025 | 1 articles | Viewed by 1193 | Submission Open

Keywords: genome-wide association study (GWAS); next-generation sequencing (NGS); multi-omics analysis; epidemiology data analysis; precision medicine approaches; disease prediction analysis

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Advances in Inborn Errors of Immunity

edited by Aleksandra Szczawińska-Popłonyk

submission deadline 30 Jun 2025 | 1 articles | Viewed by 1185 | Submission Open

Keywords: inborn errors of immunity; immune dysregulation; autoimmunity; autoinflammation; organ-specific immunopathology; immunotherapy

(This special issue belongs to the Section Molecular Immunology)

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