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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Natural Products in Cancer Prevention and Treatment

edited by

Simona Serini

and

Gabriella Calviello

submission deadline 20 Jul 2025 | 8 articles | Viewed by 10271 | Submission Open

Keywords: natural products; cancer; therapeutic strategies; novel molecular pathways

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Role of Proteomics in Human Diseases and Infections

edited by

Mahamud Ur Rashid

and Kevin Coombs

submission deadline 20 Jul 2025 | 6 articles | Viewed by 10129 | Submission Open

Keywords: proteomics; human diseases; infections; biomarkers; therapeutic targets; disease pathogenesis; host– pathogen interactions; diagnostic tools

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Hepatopancreatic and Intestine Diseases: From Molecular Basis to Therapy

edited by

Arnau Panisello-Roselló

and Emma Folch-Puy

submission deadline 20 Jul 2025 | 5 articles | Viewed by 9928 | Submission Open

Keywords: hepatopancreatic diseases; intestine diseases; molecular basis; therapy; pathogenesis; molecular pathways; pharmacological interventions; surgical techniques; immunotherapies; regenerative medicine approaches

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Viral Infections and Host Immune Responses

edited by

Barbara Ridolfi

and Maria Teresa Maggiorella

submission deadline 20 Jul 2025 | 5 articles | Viewed by 9863 | Submission Open

Keywords: virus infections; virus– host interaction; innate immunity; adaptive immunity; host factors; co-infections; acute and chronic infections; restriction factors; therapeutic strategies

(This special issue belongs to the Section Molecular Microbiology)

New Breakthroughs in Molecular Diagnostic Tools for Human Diseases

edited by

Vittorio Fineschi

and

Aniello Maiese

submission deadline 20 Jul 2025 | 8 articles | Viewed by 9843 | Submission Open

Keywords: molecular pathology; molecular diagnostics; genetics; epigenetics; proteomics; immunohistochemistry; thrombo-embolic disease; sudden cardiac death; molecular pathology of traumatic injuries; hypoxic– ischemic brain damage; experimental models of injury and diseases; targeted therapy of injuries and diseases; drug abuse; histological diagnosis; epigenetics of organs injuries; miRNA and prognosis of diseases; novel approaches and proofs of principle in therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Versatility of Protein Synthesis in a Test Tube

edited by

Tamás Mészáros

submission deadline 20 Jul 2025 | 5 articles | Viewed by 9772 | Submission Open

Keywords: protein synthesis; synthetic biology; cell-free translation; in vitro translation

(This special issue belongs to the Section Molecular Biology)

Advances in Biomedical and Tissue Engineering Strategies to Cross the Blood–Brain Barrier for Next-Generation Treatments Against Neurodegenerative Diseases

edited by

Manuele Gori

and Livia La Barbera

submission deadline 20 Jul 2025 | 5 articles | Viewed by 9687 | Submission Open

Keywords: neurodegenerative diseases; Alzheimer’ s disease; CNS; blood– brain barrier; drug delivery systems; nanocarriers; nanomedicine; tissue engineering; theranostics

(This special issue belongs to the Section Molecular Neurobiology)

A Molecular Perspective on the Genetics of Kidney Diseases

edited by Joaquim Calado

submission deadline 20 Jul 2025 | 5 articles | Viewed by 9568 | Submission Open

Keywords: kidney; genetics; solute transport; genomics; inflammation; dysmetabolism

(This special issue belongs to the Section Molecular Genetics and Genomics)

Metal-Based Drugs and Research on Mechanisms of Action

edited by

Elena K. Beloglazkina

submission deadline 20 Jul 2025 | 3 articles | Viewed by 9539 | Submission Open

Keywords: transition metals; metal complexes; metallodrugs; drug development; synthesis; imaging agents; structure– activity ratio

(This special issue belongs to the Section Molecular Pharmacology)

Hormone Signaling in Human Health and Diseases, 2nd Edition

edited by

Antonella Muscella

submission deadline 20 Jul 2025 | 6 articles | Viewed by 9520 | Submission Open

Keywords: hormone; cell receptor; endocrine signaling; cancer; insulin; oestrogen; testosterone; angiotensin; gonadotropin; thyroid hormone

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Novel Insight into Epigenomic Studies of Human Disease

edited by

Mitsuko Masutani

and Takashi Ito

submission deadline 20 Jul 2025 | 5 articles | Viewed by 9496 | Submission Open

Keywords: epigenetic regulation; DNA methylation; protein methylation; protein acetylation; histone modification; noncoding RNAs (ncRNAs); post-translational modifications (PTMs); chromatin; human disease

(This special issue belongs to the Section Molecular Genetics and Genomics)

Cutting-Edge Research and Applications of Extracellular Microvesicles in Disease Management

edited by María Isabel Torres

submission deadline 20 Jul 2025 | 5 articles | Viewed by 9367 | Submission Open

Keywords: extraccellular microvesicles; exosome; ectosoma; biomarkers; cargoes of extracellular vesicles; therapeutics; diagnosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Prostate Cancer: Novel Research and Innovative Therapeutic Strategies

edited by

Giovanni Luca Beretta

submission deadline 20 Jul 2025 | 4 articles | Viewed by 9085 | Submission Open

Keywords: prostate cancer; therapeutic strategy; castration-resistant PCa

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Progress of Opioid Research, 2nd Edition

edited by

Soichiro Ide

and

Kazutaka Ikeda

submission deadline 20 Jul 2025 | 5 articles | Viewed by 9038 | Submission Open

Keywords: opioids; opioid crisis; pain; analgesic; addiction; dependence; stress; reward; opioid peptides; opioid use disorder

(This special issue belongs to the Section Molecular Pharmacology)

Advances in Protein–Ligand Interactions

edited by Dong-Jun Yu

submission deadline 20 Jul 2025 | 5 articles | Viewed by 8865 | Submission Open

Keywords: drug design; binding specificity; molecular docking; ligand screening; structural biology; protein– protein interactions; protein– ligand interactions; protein– lipid complexes; protein– nucleic acid interactions

(This special issue belongs to the Section Macromolecules)

Genetic and Epigenetic Influences on Personality Traits and Athletic Performance

edited by

Kinga Huminska-Lisowska

submission deadline 20 Jul 2025 | 1 articles | Viewed by 8802 | Submission Open

Keywords: genetics; epigenetics; personality traits; athletic performance; polymorphisms; microbiome; neurotransmitters; molecular mechanisms; metabolic health; injury susceptibility

(This special issue belongs to the Section Molecular Genetics and Genomics)

Recent Advances in Lung Cancer

edited by

Bassam Redwan

submission deadline 20 Jul 2025 | 3 articles | Viewed by 8772 | Submission Open

Keywords: lung cancer; immunotherapy; molecular diagnostic; next-generation sequencing

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms Underlying Vulnerability to Stress-Related Disorders

edited by Marta Pardo

submission deadline 20 Jul 2025 | 3 articles | Viewed by 8721 | Submission Open

Keywords: stress-related disorders; post-traumatic stress disorder; molecular mechanisms; pharmacological targets

(This special issue belongs to the Section Molecular Neurobiology)

Dopamine, Histamine, Serotonin—Receptors, Ligands and Their Biological Role in Central Nervous System Diseases, 2nd Edition

edited by

Dorota Łażewska

and

Anna Stasiak

submission deadline 20 Jul 2025 | 4 articles | Viewed by 8682 | Submission Open

Keywords: biogenic amines (histamine; dopamine; serotonin); receptors; ligands; antagonist/inverse agonist; affinity; intrinsic activity; multitarget ligands; molecular modeling; CNS diseases; neurodegeneration; psychiatric disorders; pain; in vitro studies; in silico studies; in vivo studies

(This special issue belongs to the Section Molecular Neurobiology)

Inflammation in Chronic Disease: Molecular Mechanisms and Signaling Pathways

edited by

Nadia Lampiasi

submission deadline 20 Jul 2025 | 4 articles | Viewed by 8586 | Submission Open

Keywords: inflammation; neuroinflammation; immune response; inflammation-associated disease; inflammation mediators (proteins; enzymes; ecc); cytokines; macrophages; mast cells; monocytes; dendritic cells; oxidative stress; signaling pathways

(This special issue belongs to the Section Molecular Immunology)

Recent Advances in Molecular Mechanisms Underlying Kidney Diseases: Pathophysiology and Therapeutic Targets, 2nd Edition

edited by

George J. Dugbartey

submission deadline 20 Jul 2025 | 4 articles | Viewed by 8571 | Submission Open

Keywords: kidney diseases; pathophysiology; molecular mechanisms; therapeutic targets; acute kidney injury; chronic kidney disease; polycystic kidney disease; end-stage renal disease; IgA nephropathy; diabetic nephropathy; hypertensive nephropathy; renal cancer; kidney infarction; kidney infection; kidney failure; kidney stones; renal tubular acidosis; renal artery stenosis; acute tubular necrosis; glomerulopathy; interstitial nephritis; nephrotic syndrome; simple kidney cyst

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Signalling Pathways in Cardiovascular Pathophysiology

edited by Ernesto Alejandro Aiello

submission deadline 20 Jul 2025 | 5 articles | Viewed by 8498 | Submission Open

Keywords: heart; vascular; signaling; cardiovascular disease; mechanism

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genomic Research of Rare Diseases

edited by Shira Rockowitz and Piotr Sliz

submission deadline 20 Jul 2025 | 7 articles | Viewed by 8275 | Submission Open

Keywords: rare disease ontology; variants of uncertain significance; candidate genes; whole genome sequencing; long read whole genome sequencing; machine learning; multi-omics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Metabolisms in Cartilage Health and Diseases: 3rd Edition

edited by

Masaharu Takigawa

submission deadline 20 Jul 2025 | 5 articles | Viewed by 8164 | Submission Open

Keywords: cartilage; chondrocytes; growth; regeneration; endochondral ossification; arthritis; joint; growth factors; mechanical stress; nutrition

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

New Advances in Medical Microbiology

edited by

Alberto Rizzo

submission deadline 20 Jul 2025 | 4 articles | Viewed by 7702 | Submission Open

Keywords: clinical microbiology; clinical virology; SARS-CoV-2; HPV; sexually transmitted infections; respiratory viruses; emerging pathogens; opportunistic infections

(This special issue belongs to the Section Molecular Microbiology)

Lung Diseases Molecular Pathogenesis and Therapy

edited by

Kazufumi Nakamura

submission deadline 20 Jul 2025 | 4 articles | Viewed by 7637 | Submission Open

Keywords: lung diseases; drug therapy; chronic obstructive pulmonary disease; lung cancer; lung fibrosis; pulmonary hypertension; asthma

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Therapy of Cardiomyopathy

edited by

Maicon Landim-Vieira

submission deadline 20 Jul 2025 | 3 articles | Viewed by 7486 | Submission Open

Keywords: cardiomyopathy; nutrition; exercise; pharmacology; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Role of RNA Decay in Bacterial Gene Regulation

edited by Sue Lin-Chao and

Vladimir Kaberdin

submission deadline 20 Jul 2025 | 5 articles | Viewed by 7447 | Submission Open

Keywords: RNA stabilizers; RNA decay; RNA turnover; small regulatory RNAs; post-transcriptional control

(This special issue belongs to the Section Molecular Microbiology)

New Insights into Aquaporins: 2nd Edition

edited by

Graça Soveral

and

Inês Vieira Da Silva

submission deadline 20 Jul 2025 | 5 articles | Viewed by 7274 | Submission Open

Keywords: aquaporin; membrane channel; regulation; pathophysiology; drug target

(This special issue belongs to the Section Molecular Biology)

New Insights into Gene Expression Regulation in the Next-Generation Sequencing (NGS) Era

edited by

Maria Samara

submission deadline 20 Jul 2025 | 6 articles | Viewed by 7205 | Submission Open

Keywords: alternative splicing; DNA methylation; histone modification; RNA sequencing; epigenome; metagenomics; single-cell sequencing; spatial sequencing; microenvironment; microbiome profile

(This special issue belongs to the Section Molecular Genetics and Genomics)

Understanding Reproductive Health and Infertility: Molecular and Genetic Insights

edited by

Jan Tesarik

submission deadline 20 Jul 2025 | 7 articles | Viewed by 7121 | Submission Open

Keywords: sperm quality; oocyte quality; uterine receptivity

(This special issue belongs to the Section Molecular Biology)

Molecular Research on Genitourinary Cancers

edited by

Sabrina Bossio

and

Anna Perri

submission deadline 20 Jul 2025 | 2 articles | Viewed by 7108 | Submission Open

Keywords: genitourinary cancer; molecular markers; oxi-inflammation; tumor microenvironmental; natural products

(This special issue belongs to the Section Molecular Oncology)

Bioinformatics Study in Human Diseases: Integration of Omics Data for Personalized Medicine (Second Edition)

edited by

Hung-Yu Lin

and

Pei-Yi Chu

submission deadline 20 Jul 2025 | 6 articles | Viewed by 7089 | Submission Open

Keywords: cancers; ageing-related diseases; bioinformatics; multi-omics; pharmacogenetics; deep learning; evolutionary learning; diagnosis; prognosis; companion biomarker; drug screening; mechanism dissection

(This special issue belongs to the Section Molecular Informatics)

Targeted Treatments in Cancer: 2nd Edition

edited by

Kazuko Kaneda-Nakashima

submission deadline 20 Jul 2025 | 4 articles | Viewed by 6892 | Submission Open

Keywords: TAT (targeting alpha therapy); nuclear medicine; cancer treatment; imaging; radioisotope (RI); surface marker; TRT (targeted radioisotope therapy)

(This special issue belongs to the Section Molecular Oncology)

Microplastics and Nanoplastics Ecotoxicological Effects in Seawater and Freshwater Organisms

edited by

Carlos García

submission deadline 20 Jul 2025 | 3 articles | Viewed by 6870 | Submission Open

Keywords: microplastics; exposure; aquatic organisms; sorption; degradation; bioaccumulation; biomagnification; migration; bioindicators; marine toxins

(This special issue belongs to the Section Molecular Toxicology)

Genetic and Epigenetic Regulation of Reproduction

edited by

Dorota Juchno

and

Olga Jablonska

submission deadline 20 Jul 2025 | 4 articles | Viewed by 6769 | Submission Open

Keywords: gene expression; gene mapping; germ cells; epigenetic factors; DNA methylation; histone modification; fertility; molecular diagnostics; next generation sequencing; prenatal diagnosis

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advanced Research on Nucleic Acids: Therapeutic Potential and Applications, 2nd Edition

edited by

Veronica Esposito

and

Antonella Virgilio

submission deadline 20 Jul 2025 | 4 articles | Viewed by 6732 | Submission Open

Keywords: aptamer; decoy; DNAzyme; ribozyme; siRNA; miRNA; antisense oligonucleotide; antigene strategy; G-quadruplex; triplex

(This special issue belongs to the Section Biochemistry)

Molecular Diagnostics and Therapeutics of Epileptic Neurodevelopment

edited by Christalena Sofocleous

submission deadline 20 Jul 2025 | 2 articles | Viewed by 6649 | Submission Open

Keywords: epileptic neurodevelopment; molecular diagnostics; next-generation sequencing; genetics; epigenetics; pathogenic/likely pathogenic variants; therapeutics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Macromolecules Structure, Function, and Regulation: 2nd Edition

edited by

Zhiwei Yang

submission deadline 20 Jul 2025 | 3 articles | Viewed by 6314 | Submission Open

Keywords: conformational dynamics; structural modeling; docking; molecular recognition; regulation mechanism; rational design; molecular dynamic simulation

(This special issue belongs to the Section Molecular Biophysics)

Beyond Digestion: The Role of Gut Microbiota in Metabolism, Immunity and Brain Function

edited by

Alip Borthakur

submission deadline 20 Jul 2025 | 4 articles | Viewed by 6206 | Submission Open

Keywords: gut dysbiosis; gut microbiota; metabolism

(This special issue belongs to the Section Molecular Immunology)

Plasticity of the Nervous System after Injury: 2nd Edition

edited by

Xavier Navarro

and

Tessa Gordon

submission deadline 20 Jul 2025 | 6 articles | Viewed by 6180 | Submission Open

Keywords: neural plasticity; axonal regeneration; nerve injury; glial cells; central nervous system

(This special issue belongs to the Section Molecular Neurobiology)

Application of Biomolecular Materials in Tissue Engineering

edited by

István Hornyák

submission deadline 20 Jul 2025 | 3 articles | Viewed by 6141 | Submission Open

Keywords: biomolecular materials; tissue engineering; material science; in vitro and in vivo biodegradation; cell culture; tissue regeneration; cell scaffold; biocompatible materials

(This special issue belongs to the Section Materials Science)

Advances in Density Functional Theory and Related Methods for Molecular Computational Chemistry

edited by Paolo Umari

submission deadline 20 Jul 2025 | 3 articles | Viewed by 6107 | Submission Open

Keywords: density functional theory; quantum chemistry; algorithms; quantum computing; high-performance computing; machine learning; many-body perturbations theory; quantum Monte Carlo

(This special issue belongs to the Section Molecular Informatics)

Recent Advances in Discovery of Microbial and Plant Specialized Metabolites

edited by

Marco Masi

submission deadline 20 Jul 2025 | 4 articles | Viewed by 6076 | Submission Open

Keywords: natural products; specialized metabolites; secondary metabolites; plant; pharmacology

(This special issue belongs to the Section Molecular Plant Sciences)

Pediatric Diseases: From Molecular Mechanisms to Novel Therapeutic Strategies

edited by

Elena Tarca

submission deadline 20 Jul 2025 | 4 articles | Viewed by 6056 | Submission Open

Keywords: congenital abnormalities; genetic disease; molecular mechanism; therapeutic agents; maternal and fetal medicine; pediatric diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of RNAs in Cancers: Recent Advances

edited by Roman Beňačka

submission deadline 20 Jul 2025 | 4 articles | Viewed by 6034 | Submission Open

Keywords: cancer cells; carcinogenesis; mRNAs; ncRNAs; lncRNAs; miRNAs; circRNAs; piRNAs; RNA-based diagnostics; RNA-based therapy

(This special issue belongs to the Section Molecular Oncology)

Advances and Perspectives in Limbal Epithelial Stem Cells and Their Niche

edited by

Naresh Polisetti

and Ursula Schlötzer-Schrehardt

submission deadline 20 Jul 2025 | 3 articles | Viewed by 5955 | Submission Open

Keywords: limbal epithelial stem cells; ocular surface; limbal stem cell niche; homeostasis; limbal mesenchymal stromal cells; regeneration; limbal melanocytes; extracellular matrix components

(This special issue belongs to the Section Biochemistry)

New Insights into Plant Pathology and Abiotic Stress

edited by

Shoupu He

submission deadline 20 Jul 2025 | 4 articles | Viewed by 5921 | Submission Open

Keywords: plant pathology; abiotic stress; molecular mechanisms; stress resistance; signaling pathways; epigenetics; omics technologies; disease management; climate change; plant stress responses

(This special issue belongs to the Section Molecular Plant Sciences)

Genetic Basis of Autism Spectrum Disorder

edited by

Elisabetta Bolognesi

and

Franca Rosa Guerini

submission deadline 20 Jul 2025 | 3 articles | Viewed by 5918 | Submission Open

Keywords: autism spectrum disorder (ASD); neurodevelopmental disorder (NDD); genetic causes of autism; genetic polymorphism; gene variant; genome-wide association studies; single nucleotide; polymorphism; precision medicine; genetic mutations; diagnostic marker

(This special issue belongs to the Section Molecular Genetics and Genomics)

Recent Advances in Prevention, Diagnosis and Treatment of Pediatric Diseases

edited by

Giovanni Fiorito

submission deadline 20 Jul 2025 | 3 articles | Viewed by 5785 | Submission Open

Keywords: pediatric diseases; bioinformatics; in utero and early-life exposures; multi-omic biomarkers; personalized medicine; diagnosis; prevention

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 51-100 on page 2 of 70.

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