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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Progression of Multiple Sclerosis: Environmental Factors, Genetics, Therapeutics and Immunopathogenesis
edited by Alberto Gajofatto
submission deadline 20 Feb 2026 | 4 articles | Viewed by 9026 | Submission Open
Keywords: multiple sclerosis; disability progression; neurodegeneration; pathogenesis; immunology; risk factor; environment; genetics; treatment
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Computer-Aided Drug Design Strategies submission deadline 20 Feb 2026 | 3 articles | Viewed by 9008 | Submission Open
Keywords: computer-aided drug design; artificial intelligence in drug discovery; molecular docking; molecular dynamics simulations; macromolecular systems; quantum mechanics/molecular mechanics (QM/MM); big data analytics in drug development; pharmacokinetics optimization; structure-based drug design (SBDD); ligand-based drug design; virtual screening techniques
(This special issue belongs to the Section Molecular Informatics)
Advancements in Hematology: Molecular Biology and Targeted Therapies
edited by Fabio Stagno and
submission deadline 20 Feb 2026 | 6 articles | Viewed by 8961 | Submission Open
Keywords: hematological disorders; leukemia; lymphoma; anemia; blood malignancies; targeted therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Fish Genomics and Developmental Biology, 2nd Edition submission deadline 20 Feb 2026 | 6 articles | Viewed by 8934 | Submission Open
Keywords: development; teleost; gene regulation; comparative genomics; genomics; aquaculture; transcriptomics; gene expression; environment; genomes; population genomics; selective breeding; biomarker
(This special issue belongs to the Section Molecular Biology)
Biocatalysis of Compounds for Pharmaceutical and Biomedical Applications
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 8880 | Submission Open
Keywords: biocatalysis; biomedical application; biotechnology; compounds for pharmacy; compounds for biomedicine; enantiomers; enzyme activity; enzyme engineering; enzyme immobilization; kinetic resolution; pharmaceutical application; supports materials
(This special issue belongs to the Section Molecular Pharmacology)
Role of Diet and Nutrition in Metabolic Diseases submission deadline 20 Feb 2026 | 4 articles | Viewed by 8618 | Submission Open
Keywords: nutrients; biomarkers; molecular targets; pahodiagnosis; treatment
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Advances in Tea Tree Metabolism and Genetics
edited by Xiaoling Sun
submission deadline 20 Feb 2026 | 5 articles | Viewed by 8528 | Submission Open
Keywords: tea tree; secondary metabolite; genetic transformation; genetic breeding; tea germplasm improvement
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular and Neuromuscular Mechanisms in Skeletal Muscle Aging, 2nd Edition
edited by
submission deadline 20 Feb 2026 | 5 articles | Viewed by 8454 | Submission Open
Keywords: aging; sarcopenia; neuromuscular junction; molecular muscle modifications; myokines
(This special issue belongs to the Section Molecular Biology)
Identification of Novel Biomarkers Towards Improved Diagnosis and Management of Peripheral Vascular Diseases
edited by
submission deadline 20 Feb 2026 | 5 articles | Viewed by 8430 | Submission Open
Keywords: vascular pathophysiology; peripheral atherosclerosis; aneurysm; venous disorders; congenital vascular malformations; molecular biomarkers; diagnostic biomarkers; therapeutic targets
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms, Pathophysiology and Therapeutic Strategies of Chronic Obstructive Pulmonary Disease (COPD)
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 8406 | Submission Open
Keywords: chronic obstructive pulmonary disease (COPD); pathophysiology; novel therapeutic approaches; biomarkers; pulmonary rehabilitation; inflammation; oxidative stress; genetic factors
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Embryonic Development and Differentiation: 2nd Edition
edited by
submission deadline 20 Feb 2026 | 4 articles | Viewed by 8275 | Submission Open
Keywords: blastocyte; embryogenesis; endometrium; implantation; in vitro fertilization (IFV); ICSI; oocyte; pregnancy; seminal plasma; sperm
(This special issue belongs to the Section Molecular Biology)
Hearing Loss: Recent Progress in Molecular Genomics
edited by
submission deadline 20 Feb 2026 | 4 articles | Viewed by 8145 | Submission Open
Keywords: hearing loss; high-throughput sequencing; prognostic analyses; translational medicine; gene therapy
(This special issue belongs to the Section Molecular Genetics and Genomics)
Feature Papers in ‘Physical Chemistry and Chemical Physics’: Fourth Edition
edited by
submission deadline 20 Feb 2026 | 8 articles | Viewed by 7933 | Submission Open
Keywords: heterogeneous structures; alignment and surface phenomena; quantum theory; mathematical physics; statistical and classical mechanics; molecular structure; chemical kinetics; laser physics; dynamics; kinetics; photochemistry; spectroscopy; exciton dynamics; statistical mechanics; thermodynamics; electrochemistry; catalysis; surface science; quantum mechanics; theoretical developments; fundamental aspects of catalysis; solar energy conversion; polymer dynamics
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Advanced Research on Enzymes in Biocatalysis submission deadline 20 Feb 2026 | 8 articles | Viewed by 7868 | Submission Open
Keywords: biocatalysis; bioprocess; enzyme immobilization; enzyme production; response surface methodology (RSM); enzymatic-assisted extraction; enzymatic-catalyzed synthesis; enzyme modelling; bioreactor; bioconversion; cascade biocatalysis; enzymatic kinetic; enzyme engineering; ultrasound-assisted enzymatic reaction; directed evolution; machine learning-assisted enzyme engineering; waste-to-value bioprocesses
(This special issue belongs to the Section Biochemistry)
Circulating Non-Coding RNAs as Diagnostic and Prognostic Markers of Human Diseases: 3rd Edition submission deadline 20 Feb 2026 | 7 articles | Viewed by 7854 | Submission Open
Keywords: miRNA; gene expression regulation; diagnosis; prognosis; therapy; biomarkers
(This special issue belongs to the Section Biochemistry)
Food-Derived Bioactive Peptides
edited by and
submission deadline 20 Feb 2026 | 3 articles | Viewed by 7629 | Submission Open
Keywords: peptides identification; peptides characterization; functional foods; biological activity; peptidomics; proteomics
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Artificial Intelligence and Computer-Aided Design: Molecular Simulation Technology in Exploring Bioactive Compounds for Health Promotion
edited by
submission deadline 20 Feb 2026 | 4 articles | Viewed by 7560 | Submission Open
Keywords: molecular simulation; bioactive compounds; molecular docking; molecular dynamics; quantum mechanics; functional mechanisms
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Peripheral Neuropathies: Molecular Research and Novel Therapy—2nd Edition
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 7537 | Submission Open
Keywords: axonal degeneration; demyelination; schwann cells; dorsal root ganglia; diabetic neuropathy; chemotherapy-induced peripheral neuropathies; immune-mediated neuropathies; immune checkpoint inhibitors; charcot-marie-tooth disease; autonomic neuropathies
(This special issue belongs to the Section Molecular Neurobiology)
Exploring Novel Molecular, Metabolic and Cellular Mechanisms for Developing New Therapeutic Targets Against Childhood Cancers, 2nd Edition submission deadline 20 Feb 2026 | 3 articles | Viewed by 7373 | Submission Open
Keywords: childhood cancers; rhabdomyosarcoma; leukemias; lymphomas; central nervous system tumors; sarcomas of bone and soft tissue; neuroblastoma; retinoblastoma; rhabdoid tumors; rare cancers; genomic alterations; molecular drivers; tissue microenvironment; development of drugs; therapies
(This special issue belongs to the Section Molecular Oncology)
Gut Microbiota and Nutrition in Human Health (2nd Edition)
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 7343 | Submission Open
Keywords: microbiome; gut; brain; obesity; diabetes; inflammation; liver; nutrition; probiotic; prebiotic
(This special issue belongs to the Section Molecular Microbiology)
Molecular Pathology and Treatment of Spinal Cord Injury
edited by James Hong
submission deadline 20 Feb 2026 | 1 articles | Viewed by 7335 | Submission Open
Keywords: spinal cord injury; neuroinflammation; gene targets; neural regeneration; synaptic plasticity; molecular pathways; biomarkers; oxidative stress; apoptosis; translational research
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Insights into Plant and Insect Interactions (Second Edition)
edited by and Xiaoling Sun
submission deadline 20 Feb 2026 | 5 articles | Viewed by 7282 | Submission Open
Keywords: plant defense responses; elicitors; effectors; defense-related signaling; insect– plant interactions; tritrophic interactions; detoxification; defensive compounds; defensive genes
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Research of Cancer Metabolism and Biomarkers
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 7261 | Submission Open
Keywords: metabolic reprogramming; tumor microenvironment (TME); resistance; metabolic modulator; multidisciplinary omics approach; cancer metabolism; biomarkers; cancer stem cells
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research in Asthma and Allergy
edited by
submission deadline 20 Feb 2026 | 5 articles | Viewed by 7226 | Submission Open
Keywords: asthma; allergy; molecular mechanisms; exposome; treatment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Interplay Between Cellular Stress and Human Diseases
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 7175 | Submission Open
Keywords: cellular stress; DNA damage response; unfolded protein response; autophagy; senescence; apoptosis; repair pathways; mitochondrial stress; nutrient deprivation; oxidative stress
(This special issue belongs to the Section Biochemistry)
Recent Advances in Urological Cancer
edited by Andrea Zivi and
submission deadline 20 Feb 2026 | 1 articles | Viewed by 6806 | Submission Open
Keywords: genitourinary oncology; urologic surgery; urologic radiotherapy innovations; translational research; emerging therapies
(This special issue belongs to the Section Molecular Oncology)
Biosynthesis of Phytochemicals and Their Applications in Novel Drug Lead Development
edited by
submission deadline 20 Feb 2026 | 4 articles | Viewed by 6731 | Submission Open
Keywords: biosynthesis of phytochemicals in plants; phytochemical isolation; phytochemical structure; animal and human protein targets of phytochemicals; chemical derivatives of phytochemicals
(This special issue belongs to the Section Molecular Pharmacology)
Skin Microbiome and Skin Health: Molecular Interactions
edited by
submission deadline 20 Feb 2026 | 4 articles | Viewed by 6730 | Submission Open
Keywords: skin microbiota; human disease; human health; omics; microbiota– host interactions; microbiota manipulation; microbiota; virota; inflammatory diseases; dysbiosis
(This special issue belongs to the Section Molecular Immunology)
Molecular Diagnosis in Cardiovascular Diseases
edited by Calogera Pisano, and Giuseppe Raffa
submission deadline 20 Feb 2026 | 4 articles | Viewed by 6706 | Submission Open
Keywords: cardiac diseases; molecular diagnosis; aortopathy; aneurysm; dissection; heart failure
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Research of Nanomaterials in Molecular Science: 2nd Edition
edited by
submission deadline 20 Feb 2026 | 8 articles | Viewed by 6628 | Submission Open
Keywords: nanomaterials; medical research; synthesis and characterization; molecular formula; molecular dynamics; molecular imaging; cell signaling; cellular metabolism; tissue regeneration; biocompatibility; molecular biology; nanomedicine; functional nanomaterials; drug and gene delivery; tissue engineering; cancer therapy
(This special issue belongs to the Section Molecular Nanoscience)
Elucidating How Chondrocytes Maintain Cartilage Stability
edited by James A. Martin
submission deadline 20 Feb 2026 | 4 articles | Viewed by 6540 | Submission Open
Keywords: chondrocytes; articular cartilage; chondrogenesis; osteoarthritis; mechano-transduction; aging; extracellular matrix
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms and Treatment Strategies of Myocardial Infarction
edited by Abdul-Majeed Salmasi
submission deadline 20 Feb 2026 | 2 articles | Viewed by 6497 | Submission Open
Keywords: myocardial infarction; genetics; molecular biology; chromosomes; genes; atherosclerosis; coronary artery disease; risk factors
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research on Type 1 Diabetes and Its Complications: 2nd Edition submission deadline 20 Feb 2026 | 5 articles | Viewed by 6320 | Submission Open
Keywords: type 1 diabetes mellitus; diabetic microangiopathy; diabetic macroangiopathy; continuous glucose monitoring; experimental diabetic models; biomarkers; endothelium dysfunction; diabetes-related diseases; comorbidities; pregnancy; pathophysiology; metabolic syndrome; treatment; precision medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of Autoimmunity in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder
edited by Yang Mao-Draayer
submission deadline 20 Feb 2026 | 1 articles | Viewed by 6267 | Submission Open
Keywords: multiple sclerosis (MS); neuromyelitis optica spectrum disorder (NMOSD); myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD); immunomodulatory; neuroprotection; neuroregeneration; biomarker; imaging
(This special issue belongs to the Section Molecular Neurobiology)
Exploring the Molecular, Physiological, and Biochemical Responses of Crops to Stress
edited by
submission deadline 20 Feb 2026 | 4 articles | Viewed by 6219 | Submission Open
Keywords: molecular signaling pathways in response to biotic stresses (e.g.; bacteria; viruses; fungi; and insects); plant responses to abiotic stresses (e.g.; salinity; cold; drought; waterlogging; heat; heavy metals; and UV light); mechanisms of stress adaptation and tolerance; stress adaptation
(This special issue belongs to the Section Molecular Plant Sciences)
Advancing Climate Resilience in Horticultural Crops Through Omics Technologies
edited by and
submission deadline 20 Feb 2026 | 4 articles | Viewed by 6123 | Submission Open
Keywords: horticultural crops; climate change; omics technologies; stress responses; abiotic stresses; food security; agricultural sustainability; genomics; transcriptomic; proteomics
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Pharmacology of Medicinal Plants
edited by
submission deadline 20 Feb 2026 | 4 articles | Viewed by 6084 | Submission Open
Keywords: medicinal plants; drug development; molecular pharmacology; clinical phytopharmacology
(This special issue belongs to the Section Molecular Pharmacology)
Gut Microbiome Stability in Health and Disease
edited by and Yoshitohi Ogura
submission deadline 20 Feb 2026 | 4 articles | Viewed by 5950 | Submission Open
Keywords: gut microbiome stability; immune system; epithelial cell; mucous layer; antibiotics; diet; inflammatory bowel disease; gut microbial metabolites
(This special issue belongs to the Section Molecular Microbiology)
Molecular Mechanism of Extracellular Vesicles in Human Diseases
edited by Eszter Ágnes Tóth
submission deadline 20 Feb 2026 | 2 articles | Viewed by 5921 | Submission Open
Keywords: extracellular vesicles; intercellular communication; disease pathophysiology; biomarkers; nanoscience; biomolecular interactions
(This special issue belongs to the Section Molecular Biology)
Non-Coding RNA in Physiology and Pathophysiology: Second Edition
edited by Maria Rosaria Tumolo
submission deadline 20 Feb 2026 | 3 articles | Viewed by 5900 | Submission Open
Keywords: microRNA; long non-coding RNA; circular RNA; epigenetics; musculoskeletal pain; cardiovascular disease; metabolic disease; nervous system disorders; cancer; aging
(This special issue belongs to the Section Molecular Biology)
Molecular Research Progress of Cereal Crop Disease Resistance
edited by and Zhenqi Su
submission deadline 20 Feb 2026 | 3 articles | Viewed by 5892 | Submission Open
Keywords: cereal crops; disease resistance; resistance genes; breeding; molecular marker-assisted selection; molecular regulatory network
(This special issue belongs to the Section Molecular Plant Sciences)
Sperm Oxidative Stress and Male Infertility
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 5841 | Submission Open
Keywords: oxidative stress; antioxidant system; free radical scavengers; sperm DNA oxidation; sperm DNA fragmentatio; antioxidant therapy; male infertility; male oxidative stress infertility
(This special issue belongs to the Section Molecular Biology)
Omics-Driven Unveiling of the Structure and Function of Nanoparticles
edited by
submission deadline 20 Feb 2026 | 4 articles | Viewed by 5777 | Submission Open
Keywords: nanoparticles; nanotechnology; drug delivery; protein corona; proteomics; nano-proteomics; matabolomics; lipidomics
(This special issue belongs to the Section Molecular Biophysics)
Roles of Lipid Rafts in the Regulation of Cellular Processes and Diseases
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 5717 | Submission Open
Keywords: lipid rafts; glycosphingolipid; ganglioside; sphingomyelin; cholesterol; GPI-anchored proteins; caveolae; detergent-resistant membrane; signal transduction; disease
(This special issue belongs to the Section Biochemistry)
Marine Natural Compounds: Biotechnological Potential and Pharmacological Targets
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 5578 | Submission Open
Keywords: marine natural compounds; structure elucidation; biologic activity; structure-activity relationships; biosynthesis; biotechnology; pharmacology
(This special issue belongs to the Section Bioactives and Nutraceuticals)
New Advances in Metabolic Engineering and Synthetic Biology of Yeasts
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 5577 | Submission Open
Keywords: yeast metabolic engineering; synthetic biology; CRISPR-Cas9; metabolic pathways; bio-based chemicals; bioprocess engineering; yeast strain optimization; industrial biotechnology
(This special issue belongs to the Section Molecular Microbiology)
Inflammation in Pregnancy and Childbirth
edited by and Maciej Ziętek
submission deadline 20 Feb 2026 | 2 articles | Viewed by 5573 | Submission Open
Keywords: pregnancy; labor; eicosanoid; chronic inflammation; cytokines; intestinal dysbiosis; mitogen-activated protein kinase; nuclear factor kappa-light-enhancer-activated B cell; maresins; resolvins and protectins
(This special issue belongs to the Section Molecular Immunology)
Molecular Mechanisms of Neutrophil Extracellular Traps (Nets) in Human Diseases
edited by Eisuke F. Sato
submission deadline 20 Feb 2026 | 1 articles | Viewed by 5546 | Submission Open
Keywords: neutrophil extracellular traps (NETs); neutrophils; inflammation; autoimmune diseases; cardiovascular diseases; tumor metastasis; thrombosis; molecular mechanisms; disease progression; therapeutic targets
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Research on Gene Mutations in Cancer and Chronic Diseases
edited by Adam Szpechciński
submission deadline 20 Feb 2026 | 2 articles | Viewed by 5530 | Submission Open
Keywords: germline and somatic mutation; pathogenesis of cancer and chronic diseases; molecular techniques for gene mutation detection; biomarkers; molecular diagnostics; bioinformatics
(This special issue belongs to the Section Molecular Genetics and Genomics)
Essential Molecules in Life: Regulation, Defense, and Longevity, 2nd Edition submission deadline 20 Feb 2026 | 3 articles | Viewed by 5469 | Submission Open
Keywords: glucose metabolism and its regulation; enzimology and kinetics; metabolism and evolution; cell growth; protein synthesis and degradation; cell proliferation and apoptosis; cancer; metastasis and angiogenesis; oxidative stress; genomic; proteomic and metab
(This special issue belongs to the Section Molecular Immunology)
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