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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Crosstalk in Breast Cancer Progression and Therapies

edited by Giuseppina Daniela Naimo

submission deadline 30 Jun 2025 | Viewed by 487 | Submission Open

Keywords: breast cancer; endocrine therapy; drug resistance; breast tumor microenvironment; targeted therapies; personalized therapies; immunotherapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Next-Generation Hydrogels: Innovations in Biofunctionalization and Personalization for Targeted Biomedical Therapies

edited by

Siu Hong Dexter Wong

and Bohan Yin

submission deadline 30 Jun 2025 | Viewed by 483 | Submission Open

Keywords: biofunctionalization hydrogels; personalized hydrogels; smart hydrogel development; 3D/4D bioprinting of hydrogels; AI-driven hydrogel design; dynamic hydrogel systems; hydrogel-based vaccines and immunotherapies; smart hydrogels for controlled release

(This special issue belongs to the Section Macromolecules)

Recent Advances in Bioactive Compounds in Human Health

edited by

Dorota Gumul

submission deadline 30 Jun 2025 | 1 articles | Viewed by 475 | Submission Open

Keywords: bioactive compounds; antioxidants; food by-products; functional foods; innovative food technologies; molecular food science

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Retinoids in Ageing and Age-Related Diseases

edited by

Paul L. Chazot

submission deadline 30 Jun 2025 | Viewed by 463 | Submission Open

Keywords: retinoids; retinoic acid; ageing; age-related diseases

(This special issue belongs to the Section Molecular Biology)

Bone Development and Regeneration—4th Edition

edited by

Kazuo Yudoh

submission deadline 30 Jun 2025 | 1 articles | Viewed by 461 | Submission Open

Keywords: osteoblast; osteocyte; osteoclast; mesenchymal stem cell; cell differentiation; epigenetics; omics; integrative analysis; biomaterials

(This special issue belongs to the Section Molecular Biology)

Green Chemistry Biocatalysis—Advances in the Use of Sustainable Solvents for Biocatalytic Processes

edited by

Rita Craveiro

and

Alexandre Paiva

submission deadline 30 Jun 2025 | Viewed by 455 | Submission Open

Keywords: biocatalysts; enzymes; sustainability; green solvents; biotechnology; biochemical process engineering

(This special issue belongs to the Section Biochemistry)

Cell Membrane Electroporation and Electroosmosis Mechanisms

edited by

Paulius Ruzgys

submission deadline 30 Jun 2025 | Viewed by 426 | Submission Open

Keywords: nanosecond electroporation; calcium electroporation; small-molecule electrotransfer; abscopal effect; bacterial electroporation; irreversible electroporation; electrochemotherapy; immune response; apoptosis

(This special issue belongs to the Section Biochemistry)

Molecular Dynamics Simulations of Nanobubble for Different Applications

edited by

Ebrahim Kadivar

submission deadline 30 Jun 2025 | Viewed by 412 | Submission Open

Keywords: cavitation bubble; nanobubble dynamics; hydrodynamic cavitation; molecular dynamics simulations; laser-induced cavitation bubble; cavitation exploitation

(This special issue belongs to the Section Molecular Nanoscience)

New Advances in Cystinosis from Basic to Clinical Research

edited by Francesco Bellomo

submission deadline 30 Jun 2025 | Viewed by 398 | Submission Open

Keywords: cystinosis; kidney; Fanconi syndrome; muscles; eyes; autophagy; bioenergetics; inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advancing Redox Biomarkers in Pathological Conditions

edited by

Tatiana Armeni

and

Andrea Scirè

submission deadline 30 Jun 2025 | Viewed by 361 | Submission Open

Keywords: redox biomarkers; oxidative stress; oxidative status in pathological condition; antioxidant enzyme levels detection; low molecular weight antioxidant detection; macromolecule oxidation; oxidative PTMs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights into the Treatment of Metabolic Syndrome and Diabetes

edited by

Igor Kovalchuk

submission deadline 30 Jun 2025 | Viewed by 339 | Submission Open

Keywords: metabolic dysfunction; metabolic disorder; diabetes

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Marine Natural Compounds: Biotechnological Potential and Pharmacological Targets

edited by

Elena Leychenko

submission deadline 30 Jun 2025 | 1 articles | Viewed by 330 | Submission Open

Keywords: marine natural compounds; structure elucidation; biologic activity; structure-activity relationships; biosynthesis; biotechnology; pharmacology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in the Molecular Mechanisms and Therapies of Hepatocellular Carcinoma

edited by Lein-Ray Mo

submission deadline 30 Jun 2025 | Viewed by 310 | Submission Open

Keywords: hepatocellular carcinoma (HCC); molecular biology; biomarkers; epigenetic modulators; precision medicine; metabolic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Steatotic Liver Disease: From Bench to Bedside and Back

edited by

Federico Salomone

submission deadline 30 Jun 2025 | Viewed by 294 | Submission Open

Keywords: MASLD; ALD; MetALD; fibrosis; hepatocellular carcinoma; molecular mechanisms; molecular markers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Structure, Function and Dynamics in Proteins: 3rd Edition

edited by

Luigi Russo

submission deadline 30 Jun 2025 | Viewed by 285 | Submission Open

Keywords: protein structure and dynamics; protein– protein and protein– DNA interactions; protein folding and misfolding; protein aggregation processes; intermediate/misfolded states; conformational equilibria; DNA and ligand recognition mechanisms; membrane receptors; enzyme dynamics; metal-binding proteins; intrinsically disordered proteins; cell signaling; phase separation mechanims; solution- and solid-state NMR; molecular dynamics simulations; time-resolved X-ray; NMR relaxation; in-/on-cell NMR; cryo-EM; fluorescence polarization; surface plasmon resonance; static and dynamic light scattering; isothermal titration calorimetry; microscale thermophoresis; protein– fragment complementation assay; cross-linking; protein microarray

(This special issue belongs to the Section Molecular Biology)

Chitosan: Structural and Chemical Modification, Properties and Application, 2nd Edition

edited by

Joanna Kluczka

submission deadline 30 Jun 2025 | Viewed by 269 | Submission Open

Keywords: chitosan modification; adsorption removal; membrane separation; food preservation; environmental remediation; wastewater treatment; disease treatment; agricultural production; tissue engineering

(This special issue belongs to the Section Macromolecules)

Advances in the Nanoparticles-Based Drug Delivery in Cancer Therapy

edited by

André F. Moreira

submission deadline 30 Jun 2025 | Viewed by 260 | Submission Open

Keywords: nanoparticle-based drug delivery; stimuli responsive; cancer targeting; theragnostic nanoparticles; protein corona; combinatorial drug therapies; tumor penetration; cancer cells uptake

(This special issue belongs to the Section Molecular Nanoscience)

Phytochemicals: Mechanisms and Applications in Cancer Prevention and Therapy

edited by

Mateusz Kciuk

and

Damian Kołat

submission deadline 30 Jun 2025 | Viewed by 235 | Submission Open

Keywords: phytochemicals; cancer prevention; cancer therapy; molecular mechanisms; signal transduction pathways; anti-oxidant activity; cell death; gene regulation; therapeutic targets

(This special issue belongs to the Section Biochemistry)

Endometrial Cancer: From Basic Science to Novel Therapeutics

edited by

Hye-Yon Cho

submission deadline 30 Jun 2025 | Viewed by 230 | Submission Open

Keywords: endometrial cancer; molecular tumor pathology; tumor microenvironment; cancer epidemiology and prevention; biomarkers; cancer therapy; genomic and proteomic databases and applications

(This special issue belongs to the Section Molecular Oncology)

Polyphenol-Based Nanomaterials: Progress and Challenges

edited by

Eliana Capecchi

and

Davide Piccinino

submission deadline 30 Jun 2025 | Viewed by 223 | Submission Open

Keywords: polyphenolic small molecules; polyphenolic macromolecules; organic chemistry

(This special issue belongs to the Section Molecular Nanoscience)

Microbiome and Bioactive Compounds: Insights into Health, Disease, and Therapeutic Potential

edited by Eui-Jeong Han and

Hea-jong Chung

submission deadline 30 Jun 2025 | Viewed by 221 | Submission Open

Keywords: gut microbiome; bioactive compounds; multi-omics approaches; probiotics

(This special issue belongs to the Section Molecular Microbiology)

Organic and Inorganic Active Substances with Antimicrobial, Anti-Inflammatory, Anti-Cancer and Antioxidant Effects

edited by Jebiti Haribabu

submission deadline 30 Jun 2025 | Viewed by 221 | Submission Open

Keywords: organic compounds; metal complexes; nanomedicine; medicinal chemistry; biological applications

(This special issue belongs to the Section Molecular Pharmacology)

New Optical, Electrical, and Thermal Materials: Recent Advances and Challenges

edited by Luyi Zou

submission deadline 30 Jun 2025 | Viewed by 207 | Submission Open

Keywords: optical materials; electrical materials; thermal materials; molecular structure; molecular composition; structural performance

(This special issue belongs to the Section Materials Science)

Pathophysiology and Molecular Therapy of Brain Tumor

edited by Daizo Yoshida and Akira Teramoto

submission deadline 30 Jun 2025 | Viewed by 192 | Submission Open

Keywords: brain tumor; pathophysiology; molecular therapy; signal cascade

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Research on Alloy Materials Microstructure and Their Functionalization

edited by

Ozkan Gokcekaya

and Celaletdin Ergun

submission deadline 30 Jun 2025 | Viewed by 187 | Submission Open

Keywords: alloy design; microstructure; production methods; additive manufacturing; sol– gel process; biofunctional materials; magnetic properties; nanoparticles; ceramics; composites

(This special issue belongs to the Section Materials Science)

Molecular Insights into Antioxidant and Anti-Inflammatory Properties of Bioactive Compounds

edited by

Gang Ye

submission deadline 30 Jun 2025 | Viewed by 181 | Submission Open

Keywords: antioxidant; anti-inflammatory; bioactive compounds; artificial intelligence; multiomics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Targeted Therapy of Cancer

edited by Da-Liang Ou

submission deadline 30 Jun 2025 | Viewed by 179 | Submission Open

Keywords: pharmacotherapy; targeted therapies; immunotherapy; nanotechnology-based combination therapies; drug repurposing; tumor microenvironment; personalized medicine

(This special issue belongs to the Section Molecular Biology)

Tissue Culture-Free Plant Genome Editing and Transgenesis

edited by Degao Liu

submission deadline 30 Jun 2025 | Viewed by 176 | Submission Open

Keywords: CRISPR/Cas; genome editing; plant; tissue culture free; transgenesis

(This special issue belongs to the Section Molecular Plant Sciences)

Psoriasis: Molecular Pathologies, Lipid Disturbances, Diagnosis and Therapeutic Strategies

edited by Hanna Mysliwiec

submission deadline 30 Jun 2025 | Viewed by 173 | Submission Open

Keywords: psoriasis; pathogenesis; lipid metabolism disturbances; metabolic syndrome; systemic comorbidities; epigenetics; therapeutic strategies; biologic treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Immunotherapy of Breast Cancer

edited by Mariangela Ciccarese, Elisabetta De Matteis and Laura Orlando

submission deadline 30 Jun 2025 | Viewed by 168 | Submission Open

Keywords: subgroups of BC; biomarkers; tumour microenvironment; TIL; PD-1/PD-L1; vaccines

(This special issue belongs to the Section Molecular Oncology)

Electromagnetic Field Interactions with Biomolecules

edited by Samina Masood

submission deadline 30 Jun 2025 | Viewed by 164 | Submission Open

Keywords: magnetic field; biomolecules; medicine; drug delivery; protective methods; disease control

(This special issue belongs to the Section Biochemistry)

The Impact of Cancer–Immune Cell Crosstalk on Diagnosis, Prognosis and Treatment

edited by Fabricio Figueiro

submission deadline 30 Jun 2025 | Viewed by 159 | Submission Open

Keywords: protumoral immunity; anticancer immunity; crosstalk; tumor microenvironment; purinergic signaling; immune checkpoints; immunometabolism; extracellular vesicles; RNA communication

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Unraveling the Mechanisms Underlying Colorectal Inflammation

edited by

Soonjae Hwang

submission deadline 30 Jun 2025 | Viewed by 155 | Submission Open

Keywords: gut microbes; gut commensal; toxins; dysbiosis; colitis; inflammation; colorectal cancer

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Plant Breeding Research

edited by Qiang Zhang

submission deadline 30 Jun 2025 | Viewed by 155 | Submission Open

Keywords: crop quality; crop yield; gene editing; excellent germplasm; molecular mechanism

(This special issue belongs to the Section Molecular Plant Sciences)

Emerging Molecular Research in Microfluidics

edited by

Guorui Zhu

submission deadline 30 Jun 2025 | Viewed by 153 | Submission Open

Keywords: molecular; microfluidics; single-cell; digital microfluidics; microfluidic sensor

(This special issue belongs to the Section Biochemistry)

The Disulfide Stress in Health and Diseases

edited by

Marlena Brzozowa-Zasada

submission deadline 30 Jun 2025 | Viewed by 150 | Submission Open

Keywords: disulfide stress; oxidative Stress; redox metabolism; redox Balance; glutathione; ROS

(This special issue belongs to the Section Biochemistry)

Recent Advances in Coagulation Proteins

edited by

Arijit Biswas

submission deadline 30 Jun 2025 | Viewed by 146 | Submission Open

Keywords: coagulation proteins; hemostasis; thrombosis; structural biology; Cryo-EM; inherited coagulation disorders

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Herpesviruses (2nd Edition)

edited by

Marisa Granato

submission deadline 30 Jun 2025 | Viewed by 134 | Submission Open

Keywords: α -herpesviridae; β -herpesviridae; γ -herpesviridae; herpesviruses associated diseases

(This special issue belongs to the Section Molecular Microbiology)

Gene Function, Molecular Mechanisms, and Crop Breeding

edited by Hongwei Lu

submission deadline 30 Jun 2025 | Viewed by 131 | Submission Open

Keywords: molecular biology; gene function; molecular mechanism; crop breeding; molecular biology; agronomic traits; gene discovery; genomics; bioinfomatics; gene regulation

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms of mRNA Transcriptional Regulation: 3rd Edition

edited by

Andrey Turchinovich

submission deadline 30 Jun 2025 | Viewed by 131 | Submission Open

Keywords: transcriptoion factors (TFs); cis-regulatory elements (CREs); long non-coding RNAs (lncRNAs); short non-coding RNAs (sncRNAs); small nuclear RNAs (snRNAs); microRNA (miRNA); circular RNA (circRNA); DNA methylation; chromatin regulators

(This special issue belongs to the Section Biochemistry)

Molecular Mechanisms of Depression

edited by

Aleksandra Szczepankiewicz

submission deadline 30 Jun 2025 | Viewed by 128 | Submission Open

Keywords: antidepressants; molecular action; comorbid diseases; epigenetics; noncoding RNA; transcriptome; proteome; animal models; in vitro models; clinical studies

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms and New Therapies for Breast Cancer: 2nd Edition

edited by Mary Lou Cutler

submission deadline 30 Jun 2025 | Viewed by 123 | Submission Open

Keywords: management of metastatic disease; neoadjuvant therapy; chemotherapy and immunotherapy combination; novel biologics; aromatase inhibitors; outcome research; quality of life during and after breast cancer therapy; new targets for TNBC

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Role of Mitochondria in Neurodegenerative Diseases

edited by Małgorzata Wojtkowska

submission deadline 30 Jun 2025 | Viewed by 122 | Submission Open

Keywords: mitochondria; ccfDNA; Parkinson’ s disease’ Alzheimer’ s disease

(This special issue belongs to the Section Molecular Neurobiology)

Mechanisms of Resistance to Melanoma Immunotherapy

edited by Marko B. Lens

submission deadline 30 Jun 2025 | Viewed by 115 | Submission Open

Keywords: melanoma; immune checkpoint inhibitors; PD-1

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms, Therapeutic Challenges, and Pathogenesis of Complications in Liver Cirrhosis

edited by

Hiroteru Kamimura

submission deadline 30 Jun 2025 | Viewed by 107 | Submission Open

Keywords: muscle spasm; pruritus; sleep disturbances; sarcopenia; osteoporosis; infection; hepatopulmonary syndrome; hepatorenal syndrome; cirrhotic cardiomyopathy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Antibody Glycosylation As Immunomodulator

edited by

Maria Franzini

submission deadline 30 Jun 2025 | Viewed by 106 | Submission Open

Keywords: antibodies; glycosylation pattern; immune system; inflammation; autoimmunity; glycans biosynthesis

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanism of Immune Response

edited by Marisa Mariel Fernández

submission deadline 30 Jun 2025 | Viewed by 93 | Submission Open

Keywords: training of the innate immune response; antigen recognition; cell migration; autoimmune processes; cell differentiation; tolerance; molecular responses of epithelial cells to foreign stimuli; alterations in immune checkpoints; modulation of immune responses; mechanisms of hypersensitivity

(This special issue belongs to the Section Molecular Immunology)

Molecular Insights into Mitochondrial Function and Oxidative Stress

edited by Sonia Silvestri and Patrick Orlando

submission deadline 30 Jun 2025 | Viewed by 77 | Submission Open

Keywords: life sciences; mitochondria functionality; mitochondrial nutrients; oxidative stress; bioactive molecules; aging-associated diseases

(This special issue belongs to the Section Biochemistry)

The Cellular, Synaptic and Molecular Mechanisms of Action of Central Nervous System Drugs 2.0

edited by

M. Bruce MacIver

submission deadline 10 Jul 2025 | 4 articles | Viewed by 15004 | Submission Open

Keywords: CNS; drug; addiction; memory; consciousness; loss of consciousness; recovery of consciousness; coma; anesthesia; anaesthesia; anesthetic; inhalant; abuse; GABA; glutamate; 5-HT; adrenaline; noradrenaline; serotonin; dopamine; adenosine; reanimation; electrical stimulation

(This special issue belongs to the Section Molecular Neurobiology)

Understanding Allergy and Asthma at the Molecular Level

edited by

Cenk Suphioglu

submission deadline 10 Jul 2025 | 1 articles | Viewed by 3524 | Submission Open

Keywords: allergy; asthma; allergens; allergic asthma; thunderstorm asthma; cell culture; biomarkers; proteomics; metabolomics; lipidomics; genomics; recombinant allergens; recombinant hypoallergens; signalling; inhibitors; cytokines

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 51-100 on page 2 of 70.

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