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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Boosting the Production of Bioactive Compounds: Biotechnology and Metabolic Engineering of Medicinal Plants

edited by

Katarzyna Hnatuszko-Konka

and

Izabela Grzegorczyk-Karolak

submission deadline 20 Sep 2025 | 5 articles | Viewed by 9094 | Submission Open

Keywords: bioactive compounds; plant tissue culture; elicitors; metabolic engineering; gene expression; medicinal plants; metabolic pathway; plant biotechnology

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research of Epithelial Function and Barrier Dysfunction

edited by Fariba Rezaee

submission deadline 20 Sep 2025 | 5 articles | Viewed by 9054 | Submission Open

Keywords: epithelial cells; actin cytoskeleton; viral infection; apical junctional complex; tight junction; adherens junction; barrier dysfunction; trans-epithelial electrical resistance; permeability; epithelial barrier

(This special issue belongs to the Section Molecular Immunology)

Advances in Melanoma and Skin Cancers: 2nd Edition

edited by

Domenico Mallardo

Debora Basile

and Maria Grazia Vitale

submission deadline 20 Sep 2025 | 6 articles | Viewed by 9028 | Submission Open

Keywords: melanoma; immunotherapy; biomarkers; translational research; drug repurposing; clinical outcome; prognostic markers; predictive markers; combination immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Mycotoxins, Immunity, and Inflammation

edited by

Yuseok Moon

submission deadline 20 Sep 2025 | 5 articles | Viewed by 8994 | Submission Open

Keywords: mycotoxin; immunity; inflammation; immunotoxicity; immunology

(This special issue belongs to the Section Molecular Toxicology)

Editorial Board Members’ Collection Series: Autoimmune Diseases—2nd Edition

edited by

Yves Renaudineau

and

Dirk Roggenbuck

submission deadline 20 Sep 2025 | 5 articles | Viewed by 8912 | Submission Open

Keywords: autoimmunity; autoimmune diseases; immunotherapy; biomarkers; pathogenic mechanisms

(This special issue belongs to the Section Molecular Immunology)

Molecular Basis of Pancreatic Secretion and Metabolism

edited by

Dongki Yang

submission deadline 20 Sep 2025 | 5 articles | Viewed by 8835 | Submission Open

Keywords: exocrine of the pancreas; endocrine of the pancreas; acute pancreatitis; chronic pancreatitis; cystic fibrosis; pancreatic metabolic hormones; pancreatic metabolic disease; mechanism of pancreatic bicarbonate secretion; the sodium bicarbonate cotransporter (NBC); cystic fibrosis transmembrane conductance regulator (CFTR); regulators of the ion channels and ion transporters involved in secretion

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Application of Natural Products in Biomedicine and Pharmacotherapy: 2nd Edition

edited by

George Miloshev

submission deadline 20 Sep 2025 | 7 articles | Viewed by 8647 | Submission Open

Keywords: natural products; biomedicine; genotoxicity; epigenetics; aging

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanisms of Microbe–Skin Interactions

edited by

Friedrich Götz

submission deadline 20 Sep 2025 | 4 articles | Viewed by 8548 | Submission Open

Keywords: colonization; cosmetics; diseases (e.g.; acne; diabetic foot syndrome (DFS); psoriasis; etc.); health; immunity; lipidomics; metabolomics; metagenomics; neurotransmitter; physiology; skin habitat; skin microbiota; prebiotics; probiotics; wound healing

(This special issue belongs to the Section Molecular Microbiology)

Bioactive Compounds and Their Anticancer Effects

edited by

Ji Hoon Jung

submission deadline 20 Sep 2025 | 5 articles | Viewed by 8479 | Submission Open

Keywords: ferroptosis; natural compounds; bioactive compounds; p53; anti-cancer drugs

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Drug Discovery: Design, Synthesis and Activity Evaluation

edited by

Joana L. C. Sousa

and

Artur M. S. Silva

submission deadline 20 Sep 2025 | 4 articles | Viewed by 8413 | Submission Open

Keywords: drug design; organic synthesis; biological activity evaluation; biologically active compounds; diagnostic/therapeutic agents; labeled ligands; structure– activity relationships (SARs); structural biological studies; computational studies; pharmacokinetics/pharmacodynamics; drug delivery

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Biology of Protein Kinases: Regulatory Mechanisms, Therapeutic Targets and Cancer Treatments

edited by Jaw Ji Yang

submission deadline 20 Sep 2025 | 2 articles | Viewed by 8407 | Submission Open

Keywords: protein kinases; signal transduction; cancer therapy; regulatory mechanisms; kinase inhibitors; therapeutic targets; molecular biology; structural biology; translational research; clinical applications

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms and Therapies for Metabolic-Associated Fatty Liver Diseases

edited by Yi-Ming Arthur Chen

submission deadline 20 Sep 2025 | 3 articles | Viewed by 8261 | Submission Open

Keywords: metabolic-associated fatty liver disease; MAFLD; metabolic dysfunction-associated steatohepatitis; MASH; molecular mechanism; genetic polymorphism; individualized medicine; prevention; new drug development; health supplements; diagnosis; epidemiology; lifestyle

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role and Mechanism of P2X7 Receptor in Cancer and Inflammatory Diseases

edited by

Anna Lisa Giuliani

submission deadline 20 Sep 2025 | 3 articles | Viewed by 8118 | Submission Open

Keywords: P2X7 receptor; inflammation; cancer; purinergic signalling

(This special issue belongs to the Section Molecular Immunology)

Advances in Research for Legume Genomics, Genetics, and Breeding, 2nd Edition

edited by

Naoufal Lakhssassi

submission deadline 20 Sep 2025 | 5 articles | Viewed by 8114 | Submission Open

Keywords: legumes; genomics; plant breeding; seed composition; gene function; biotic and abiotic stress; legume pathogen resistance/mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

New Advances in Stem Cells in Human Health and Diseases

edited by

Elisaveta N. Voynova

submission deadline 20 Sep 2025 | 6 articles | Viewed by 8039 | Submission Open

Keywords: stem cells biology; iPSCs; hESC

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanism and Treatment of Diabetes Mellitus and Its Complications

edited by

Bernd Stratmann

submission deadline 20 Sep 2025 | 6 articles | Viewed by 7754 | Submission Open

Keywords: MODY; LADA; diabetes late complications; molecular mechanisms; omics; polyneuropathy; microvascular disease; macrovascular disease; liver disease

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

State-of-the-Art Molecular Immunology in Chile, 2nd Edition

edited by

Marcela Hernandez Ríos

Juan C. Aguillon

, María Rosa Bono,

Nicolas Dutzan

Rolando Vernal

and

Leandro J. Carreño

submission deadline 20 Sep 2025 | 3 articles | Viewed by 7740 | Submission Open

Keywords: innate immunity; adaptive immunity; host– pathogen interactions; immunopathology; osteoimmunology; immunosenescence; immunotherapy; antibody; vaccines; Chile

(This special issue belongs to the Section Molecular Immunology)

Natural Compounds for Counteracting GI and Liver Diseases

edited by

Daniela Gabbia

and

Raquel Abalo

submission deadline 20 Sep 2025 | 4 articles | Viewed by 7693 | Submission Open

Keywords: natural compounds; gastrointestinal diseases; liver diseases; pharmacological potential

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Application of Genetic Engineering in Treatments for Human Diseases

edited by Claudio Mussolino

submission deadline 20 Sep 2025 | 2 articles | Viewed by 7666 | Submission Open

Keywords: genome editing; epigenome editing; CRISPR-Cas systems; gene therapy; precision medicine; molecular mechanisms; innovative therapies; gene expression regulation

(This special issue belongs to the Section Molecular Genetics and Genomics)

New Insights into Anti-cancer Drug Discovery and Development

edited by

Ki-cheong Park

submission deadline 20 Sep 2025 | 3 articles | Viewed by 7331 | Submission Open

Keywords: anti-cancer drug resistant; cancer recurrence; cancer metastasis; cancer stem cells; target validation; target identification; metabolic reprogramming of cancer stem cells; unmet medical needs

(This special issue belongs to the Section Molecular Pharmacology)

The Role of Oxidative Stress and Antioxidants in Human Disease

edited by

Federica Mannino

submission deadline 20 Sep 2025 | 4 articles | Viewed by 6893 | Submission Open

Keywords: oxidative stress; free radicals; antioxidants; reactive oxygen species (ROS); polyphenols

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Role of Natural Products in Health and Diseases

edited by

Katarína Bauerová

submission deadline 20 Sep 2025 | 4 articles | Viewed by 6803 | Submission Open

Keywords: natural products; health; chronic diseases; biomolecular research; functional food; oncology; rheumatology; infections; inflammation; autoimmunity

(This special issue belongs to the Section Molecular Pharmacology)

Nutraceuticals for the Maintenance of Brain Health

edited by

Maria Anttonietta Panaro

submission deadline 20 Sep 2025 | 5 articles | Viewed by 6800 | Submission Open

Keywords: vitamin; nutraceutics; brain; neuroinflammation; neurodegeneration; cognitive function

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Emerging Advances in Cancer Biomarkers: Machine Learning, Radiomics, Genomics, and More

edited by

Hung-Yu Lin

and

Pei-Yi Chu

submission deadline 20 Sep 2025 | 3 articles | Viewed by 6744 | Submission Open

Keywords: cancers; biomarkers; precision medicine; artificial intelligence; machine learning; radiomics; genomics; radiogenomics; multi-omics; pharmacogenetics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Apoptosis and Autophagy as Strategies in Cancer Treatment

edited by Dorota Ciołczyk-Wierzbicka

submission deadline 20 Sep 2025 | 3 articles | Viewed by 6732 | Submission Open

Keywords: apoptosis; autophagy; cancer therapy/treatment; drug resistance; signaling pathways

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of SARS-CoV-2 in Immunomodulation—Post-Pandemic Reflection on the Role of Viruses in Human Immunology

edited by

Katarzyna A. Lisowska

submission deadline 20 Sep 2025 | 4 articles | Viewed by 6666 | Submission Open

Keywords: SARS-CoV-2; COVID-19; immunomodulation; T cells; B cells; dendritic cells; monocytes; cytokines

(This special issue belongs to the Section Molecular Immunology)

Advances in Neurodegenerative Diseases and Inflammation: Pathogenesis, Biomarkers and Treatments

edited by

Luisa Agnello

and Anna Maria Ciaccio

submission deadline 20 Sep 2025 | 2 articles | Viewed by 6632 | Submission Open

Keywords: neurodegeneration; inflammation; biomarkers; Alzheimer’ s disease; molecular mechanism; pathogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Noncovalent Interactions and Applications in Materials and Catalysis

edited by Snežana D. Zarić

submission deadline 20 Sep 2025 | 4 articles | Viewed by 6448 | Submission Open

Keywords: noncovalent interactions; materials; catalysis; crystal structures; quantum chemistry calculations; hydrogen bonds; stacking interactions; spectroscopy

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Physiological Functions and Pathological Effects of Microglia

edited by Hiroshi Nakanishi

submission deadline 20 Sep 2025 | 4 articles | Viewed by 6304 | Submission Open

Keywords: circadian clock; homeostasis; immune response; microglia; neurodegenerative diseases; neuroinflammation; neuropsychiatric disorders; neuromodulation; phagocytosis; synaptic pruning

(This special issue belongs to the Section Molecular Neurobiology)

Biofunctional Coatings for Medical Applications

edited by

Liviu Duta

Valentina Grumezescu

and

Gabriela Dorcioman

submission deadline 20 Sep 2025 | 4 articles | Viewed by 6265 | Submission Open

Keywords: biofunctional coatings; thin film deposition techniques; surface engineering; tissue engineering; materials’ doping and co-doping; medical applications

(This special issue belongs to the Section Materials Science)

Exploring the Pathogenetic Mechanisms in Respiratory Virus Infections: Recent Advances and Future Directions

edited by

Marta De Angelis

submission deadline 20 Sep 2025 | 3 articles | Viewed by 6250 | Submission Open

Keywords: respiratory viruses; virus-host interactions; inflammation; metabolic pathways

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bilirubin: Health Challenges and Opportunities

edited by

Silvia Gazzin

submission deadline 20 Sep 2025 | 3 articles | Viewed by 6239 | Submission Open

Keywords: bilirubin; biomedical science; neurobiology; Parkinson’ s disease; brain neuroprotection

(This special issue belongs to the Section Molecular Biology)

Molecular Genetics of Breast Cancer—Recent Progress

edited by

Virginia Valentini

submission deadline 20 Sep 2025 | 4 articles | Viewed by 6097 | Submission Open

Keywords: hereditary cancer; female breast cancer; male breast cancer; molecular oncology; cancer genetics; NGS of gene panels; transcriptomics; genetic predisposition to breast cancer; breast cancer risk; tumor profiling; predictive biomarkers; personalized treatment

(This special issue belongs to the Section Molecular Oncology)

Bioactive Compounds in Human Brain Structures and Diseases: 2nd Edition

edited by

Terezia Kiskova

submission deadline 20 Sep 2025 | 4 articles | Viewed by 5952 | Submission Open

Keywords: brain; brain cancer; depression; neurodegenerative disorders; natural compounds

(This special issue belongs to the Section Molecular Neurobiology)

Advanced Synthetic Methodologies in Drug Development

edited by

Davide Moi

submission deadline 20 Sep 2025 | 3 articles | Viewed by 5842 | Submission Open

Keywords: organic chemistry; medicinal chemistry; catalysis; photo-catalysis; green chemistry; drug design; drug analysis; flow chemistry

(This special issue belongs to the Section Molecular Pharmacology)

Small Molecule Drug Design and Research: 3rd Edition

edited by

Adel Nefzi

submission deadline 20 Sep 2025 | 4 articles | Viewed by 5837 | Submission Open

Keywords: drug design; diversity-oriented synthesis; combinatorial chemistry; computationally guided synthesis; drug-like compounds; computer modeling techniques

(This special issue belongs to the Section Molecular Pharmacology)

Recent Progress in Advanced Computing Techniques for Molecules and Nanomaterials

edited by

Joonho Bae

submission deadline 20 Sep 2025 | 1 articles | Viewed by 5812 | Submission Open

Keywords: nanomaterials; machine learning; artificial intelligence; computing techniques; modeling; energy storage; catalysis

(This special issue belongs to the Section Molecular Nanoscience)

Cytokine Networks in Inflammatory Skin Diseases

edited by

Emanuele Scala

submission deadline 20 Sep 2025 | 2 articles | Viewed by 5762 | Submission Open

Keywords: chronic inflammatory skin diseases; immunopathogenesis; inflammatory pathways; cytokines; molecular targets; psoriasis; atopic dermatitis; hidradenitis suppurativa; urticaria; lichen planus

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

C. elegans as a Disease Model: Molecular Perspectives: 2nd Edition

edited by

Krisztina Takács-Vellai

submission deadline 20 Sep 2025 | 5 articles | Viewed by 5682 | Submission Open

Keywords: Caenorhabditis elegans; model organism; disease model; neurodegenerative diseases; cancer model; ageing

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights in Prion Diseases

edited by

Eva Bagyinszky

submission deadline 20 Sep 2025 | 1 articles | Viewed by 5610 | Submission Open

Keywords: prion diseases; prion mutation; genetic modifier; neurodegenerative diseases; therapy; neuroprotection

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insights on Drug Discovery, Design, and Treatment

edited by Chih Kang Chiang

submission deadline 20 Sep 2025 | 4 articles | Viewed by 5607 | Submission Open

Keywords: antibacterial drugs; antiviral drugs; antioxidant drugs; anti-inflammatory drugs; antibiotics; anticancer drugs; drug discovery; drug development; drug design; drug delivery; drug carriers; nanoparticles; molecular modeling; molecular mechanisms; crystallography; pharmacokinetics; molecular activity; inhibitors and antagonists

(This special issue belongs to the Section Molecular Pharmacology)

Bacterial Adaptation Strategies to the Host: From Acute, Aggressive to Chronic, Dormant Infections, 2nd Edition

edited by

Bettina Löffler

submission deadline 20 Sep 2025 | 2 articles | Viewed by 5552 | Submission Open

Keywords: dormancy; phenotype switching; bacterial stress; survival strategies; persisters; resuscitation; starvation; cell cycle arrest; ATP homeostasis

(This special issue belongs to the Section Molecular Microbiology)

Molecular Research Progress of Skin and Skin Diseases: 2nd Edition

edited by

Ji Hyun Lee

submission deadline 20 Sep 2025 | 5 articles | Viewed by 5551 | Submission Open

Keywords: atopic dermatitis; psoriasis; alopecia; vitiligo; acne; skin cancer; JAK-STAT; inflammatory skin disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Genetics and Breeding Mechanisms in Domestic Animals: 3rd Edition

edited by

Guiping Zhao

submission deadline 20 Sep 2025 | 4 articles | Viewed by 5531 | Submission Open

Keywords: animal genetics; animal breeding; functional genomics; multiomics analysis; molecular immunity; interactions between microbe and host

(This special issue belongs to the Section Molecular Genetics and Genomics)

TRP Channels for Pain, Itch and Inflammation Relief: 2nd Edition

edited by

Arpad Szallasi

and

Ari-Pekka Koivisto

submission deadline 20 Sep 2025 | 2 articles | Viewed by 5423 | Submission Open

Keywords: TRP channels; “ thermoTRP” channels; neuropathic pain; inflammatory pain; cancer pain; pruritic skin iseases; itch; neurogenic inflammation; migraine

(This special issue belongs to the Section Molecular Immunology)

Cellular and Molecular Biology in the Compromised Neonate

edited by

Tim G. A. M. Wolfs

submission deadline 20 Sep 2025 | 1 articles | Viewed by 5196 | Submission Open

Keywords: compromised neonate; infections; placental dysfunction; disrupted oxygen supply; molecular and cellular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Musculoskeletal Diseases: Inflammation, Degeneration or Mechanical Stress

edited by

Gianluigi Pasta

submission deadline 20 Sep 2025 | 2 articles | Viewed by 5184 | Submission Open

Keywords: musculoskeletal diseases; inflammation; degeneration; mechanical stress; aging

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Translational Research of Non-Small Cell Lung Cancer

edited by

Xabier Mielgo Rubio

submission deadline 20 Sep 2025 | 1 articles | Viewed by 5110 | Submission Open

Keywords: non-small cell lung cancer; precision medicine; targeted therapy; resistance mechanisms; immunotherapy; molecular biomarkers

(This special issue belongs to the Section Molecular Oncology)

New Trends in Research on Cerebral Ischemia

edited by Hideaki Imai

submission deadline 20 Sep 2025 | 3 articles | Viewed by 5082 | Submission Open

Keywords: white matter damage; ischemia; axon regeneration; intervention; cell transplantation; exosome therapy; stem cells; myelin integrity; neurological disorders; neural repair; cognitive impairments

(This special issue belongs to the Section Molecular Neurobiology)

Pituitary Tumors: An Update in the Pathogenetic Mechanisms, the Diagnostic Methods and the Therapeutic Approaches

edited by

Dimitrios Kanakis

submission deadline 20 Sep 2025 | 3 articles | Viewed by 5059 | Submission Open

Keywords: pituitary neuroendocrine tumors (PitNETs); pituitary transcription factors; PIT1; TPIT; SF1; GATA3; ERα ; pituicytoma; hypothalamic neurocytoma; hypothalamic gangliocytoma

(This special issue belongs to the Section Molecular Oncology)

Displaying special issue 51-100 on page 2 of 70.

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