T Cells and Innate Lymphoid Cells in the Immune Response against Hematological Malignancies

Dear Colleagues,

During the last two decades, the microenvironmental issue has been recognized as a crucial part of cancer-related processes. In this context, the immune response of innate and adaptive origins against tumors seems to be an equalizer in determining the fate of cancer cells. Immune cell subsets, belonging to the T cells and innate lymphoid cells (ILC), including natural killer cells, are the subject of intense studies concerning the tumorigenesis, progression, and therapy of different hematological malignancies. Considerable efforts are being dedicated to identifying therapeutic strategies to overcome tumor immune evasion, as well as modifying T and NK cells to enhance their capacity to reach tumor sites and recognize tumor cells.

This Special Issue will be devoted to collecting original research papers, as well as reviews, focused on exploring the crosstalk between hematopoietic cancer cells and immune T or innate lymphoid cells from multiple points of view, including, but not limited to, the bidirectional influence exerted on tumor development/progression, on one side, and on polarization/function/cell-to-cell signaling, on the other side. We also welcome manuscripts related to the potential therapeutic fallout of strategies to boost T and innate lymphoid cell activation, with particular regard to those that impact immuno-suppression and immuno-evasion processes.

Dr. Antonio F. Campese
Dr. Giovanni Bernardini
Guest Editors

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