Hormonal Diversity: From Organogenesis to Neurodegeneration

Dear Colleagues,

Hormones control numerous processes in the body, including growth and development, reproduction, metabolism, and internal milieu or homeostasis. Regulation of the hypothalamic–pituitary–thyroid–adrenal–gonadal (HPTAG) auto regulating axis, involving a well-balanced endocrine circadian rhythmicity, is crucial to bodily homeostasis, and thus the appropriate development and function of a multitude of organs facilitating healthy physiological activities. Disruption in the HPTAG system, involving the structural and functional efficacies of all organs, affects the central nervous system and the endocrine system, resulting in a decline in various hormones. Hormone deficiencies modulate the immune system, develop an array of physiological anomalies, ranging from carcinogenesis to neurodegeneration, and contribute to increased morbidity and mortality. The majority of these conditions profoundly affect geriatric populations. Senescence is the hallmark of aging that is triggered by numerous factors and/or events, including epigenetic dysregulation, DNA damage, and dysfunction in mitochondrial network, which eventually links to a wide variety of health complications and diseases. Aging is also associated with a host of pathologies, including cancers (both hormone dependent and independent), cardiovascular diseases, and neurodegenerative disorders connecting cognitive impairment and dementia, many of which are particularly influenced by immunocompromised conditions. Therapeutic strategies, involving vitamins and nutrients, facilitating and/or reversing hormonal equilibrium/homeostasis and/or immunomodulation towards younger levels, are the prerequisite for healthy living and/or aging.

This Special Issue of hormonal diversity on a variety of physiological, as well as pathophysiological, aspects provides a venue for publishing both original research and review articles that enhance our in-depth understanding of fundamental cellular and molecular mechanisms in health and diseases.

Dr. Pulak R. Manna
Guest Editor

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• hormone regulation and function
• physiologic events
• HPTAG auto regulating system
• bodily homeostasis
• hormonal imbalance
• hormone dysregulation and pathophysiology
• vitamins and healthy aging
• age-related diseases
• cancers
• immunocompromised conditions
• neurodegenerative disorders