Molecular Pathways and New Therapies for Breast Cancer

Dear Colleagues,

Breast cancer is the most common malignancy in women worldwide. Due to its heterogeneity, the molecular mechanisms governing breast cancer development and progression are complex and impact prognosis and treatment efficacy. Depending on the expression of the estrogen receptor, the progesterone receptor, and the human epidermal growth factor receptor 2 (HER2), breast cancer can be classified as luminal, HER2-enriched, and triple-negative. Each sub-type possesses different treatment strategies, prognostic, and treatment response rates. Therefore, investigating molecular mechanisms of tumor progression, resistance and metastasis is crucial to better understand and identify at-risk patients and develop novel targets and treatment strategies in order to improve breast cancer patient prognosis.

The goals of this Research Topic are to elucidate the molecular mechanisms underlying cancer progression in patients with breast cancer. We aim to focus on identifying novel intrinsic and extrinsic molecular pathways. Furthermore, we will also focus on novel treatment proposals and innovative approaches to develop novel treatments and better identify patients who are at high risk of failing current standard approaches.

This Special Issue of IJMS will welcome original research and review articles discussing novel signaling pathways and therapy in breast cancer.

Dr. Josiah Ochieng
Guest Editor

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• breast cancer
• cell signaling
• molecular heterogeneity
• targeted therapies
• HER2
• biomarkers