Neurological Disorders: Molecular Pathology and Therapeutic Approaches

Dear Colleagues,

Neurological disorders represent a wide range of conditions affecting the central and peripheral nervous systems. Their study is crucial because of their significant impact on public health and patient quality of life. The molecular pathology of these disorders involves complex mechanisms, including genetic mutations, protein dysfunction, oxidative stress, and neuroinflammation. These factors contribute to the neuronal degeneration and synaptic dysfunction characteristics of diseases such as Alzheimer’s, Parkinson’s, multiple sclerosis, and epilepsy.

The development of innovative therapeutic approaches has been driven by an understanding of the underlying molecular pathology. Targeted therapies, which include drugs designed to interact with specific molecules, offer the potential to modify the course of disease. Gene and cell therapies, as well as the modification of microbial profiles, are emerging as promising strategies to correct genetic defects and regenerate damaged neuronal tissue. The use of biomarkers for the early diagnosis and monitoring of disease progression has significantly improved clinical management.

Continued research in this field is essential for the development of more effective and personalized treatments. The combination of advances in molecular biology, genetics, and biotechnology promises to transform the therapeutic approach to neurological disorders.

The following topics are proposed for this SI:

• Intracellular signalling networks in neurological disorders.
• Identification of new therapeutic targets.
• Genetics of neurological disorders: identification and treatment of mutations.
• Mitochondrial diseases and neurodegeneration.
• Gene therapy in neurological diseases: recent advances.
• Neuroinflammation in autoimmune disorders of the central nervous system.
• Impact of the microbiome on neurological health.

Prof. Dr. Ana Isabel Beltrán-Velasco
Guest Editor

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The following topics are proposed for this SI:
Intracellular signalling networks in neurological disorders.
Identification of new therapeutic targets.
Genetics of neurological disorders: identification and treatment of mutations.
Mitochondrial diseases and neurodegeneration.
Gene therapy in neurological diseases: recent advances.
Neuroinflammation in autoimmune disorders of the central nervous system.
Impact of the microbiome on neurological health.

This special issue is now open for submission.