Recent Research on Novel Lipid-Based Nano Drug Delivery Systems

Dear Colleagues,

Approximately 40% of the materials used to manufacture nano drug delivery systems and present in the global pharmaceutical market since 1995 are based on sn-1,2 fully saturated synthetic phospholipids and cholesterol. Today, however, the attention of the industry and consumers has been directed to the search for new pharmaceutical biomaterials from plants, fungi and extremophilic microorganisms (microalgae, bacteria, and archaea) exhibiting novel stereoisomeric forms, novel carbon–oxygen bonds, novel headgroups and general molecular shapes as sources of lipids that can be used to prepare innovative nanoparticulate material.

Nano drug delivery systems have thus begun to emerge based on new natural biomaterials, capable of presenting greater structural stability in biological environments, greater superficial simplicity—which would facilitate their subsequent structural characterization—and even bioactivity per se, in addition to offering new pharmacodynamics and potentially new toxicities not previously described.

This Issue will gather the latest contributions (review, original research) in the experimental therapeutic field, including discussions of the structural characterization, pharmacodynamics and cytotoxicity of 2D or 3D models, as well as pharmacokinetics, biodistribution or therapeutic activity in vivo. Relevant articles will employ nano drug delivery systems, prepared with new natural lipids, as well as their derivatives produced by chemical synthesis. 

Dr. Eder Lilia Romero
Guest Editor

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• lipids
• nanoparticle
• nanovesicle
• algae
• archaea
• plant
• bacteria
• natural product