Recent Insights on Macrocyclic-Based Hybrid Assemblies with Stimuli-Responsiveness

Dear Colleagues,

Readily accessible, synthetic bio-soft macrocycles have gained the attention of the scientific community thanks to their increased versatility in medicinal chemistry. Stimuli-responsive  hybrid assemblies, based on both native and synthetic macrocycles, are a recently investigated research area in various fields,  ranging from chemistry to material science. In the field of nanomaterials for the treatment of damaging diseases, recent developments concerning single-molecule- and multi-stimuli-driven supramolecular hybrid assemblies have led from single- to multimodal therapeutic and diagnostic effects. With the incorporation of responsive functionalities, these hybrid nanoplatforms can be responsive to various stimuli, such as light, pH, heat, temperature, redox, enzymes, and magnetic fields. This Special Issue welcomes the submission of original research papers dedicated to noteworthy advances in macrocyclic-based hybrid assemblies and those obtained by supramolecular approaches, with stimuli-responsiveness in terms of design, synthesis, and applications. The focus of the research can be on the following topics:

1. Design, synthesis, and characterization of novel macrocycle-based hybrids with stimuli-responsiveness;
2. Supramolecular nanohybrids and hybrids with plasmonic, magnetic, redox, and luminescent properties;
3. Supramolecular nanomaterials with phototherapeutic and photodiagnostic action;
4. Theranostic assemblies.

Prof. Dr. Antonino Mazzaglia
Dr. Roberto Zagami
Dr. Mariachiara Trapani
Guest Editors

Manuscript Submission Information

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• stimuli-responsive materials
• supramolecular hybrid assemblies
• macrocyclic-based nanoassemblies
• plasmonic nanoassemblies
• magnetic nanoassemblies
• phototherapeutic nanoassemblies
• drug delivery
• theranostic nanoassemblies