Epidemiological Studies of Chronic Exposures to Radon: Additive and Multiplicative Models and Quality Assessment of Individual Exposures
A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Environmental Health".
Deadline for manuscript submissions: closed (30 June 2018) | Viewed by 5077
Special Issue Editor
Special Issue Information
Dear Colleagues,
Lung cancer risk in radon exposed miners has generally been studied since the 1960s using a cohort designs. The risk from residential radon was studied substantially later (since the 1980s) mostly using case-control designs. In both designs, the risk has been described in relative risk models, assuming multiplicative effects between the background risk and the risk from radon exposure. The additive risk models, where the background risk and radon exposure induced risks are added, were not explicitly reported. In both approaches, the risk models can be improved by inclusion of modifying factors, similar to the Japanese Life Span Study of atomic bomb survivors (LSS).
The aim of the present Special Issue is to report results based on both additive and multiplicative models and compare the models with LSS. In studies with individual smoking information, the interaction between radon and smoking can be explicitly modelled. In studies where individual smoking data are not available, estimated background rates can be compared with national lung cancer rates. Resulting models for studies with smoking data and those without smoking data can be compared. In addition, statistical power for distinguishing the additive and multiplicative model can also be studied.
In addition of the above, a study of quality of exposure can be realized, including description of methods used in individual exposure estimates. This study can be complemented by risk estimated for different periods of exposure and job categories like hewers, other manual workers (maintenance, support, technical and supervising underground workers).
Dr. Ladislav Tomášek
Guest Editor
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Keywords
- Lung cancer
- Radon
- Multiplicative and additive risk models
- Modifying factors
- Quality assessment of individual exposures
- Smoking
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