Special Issue "Mechanisms of mRNA Nuclear Export"
A special issue of Genes (ISSN 2073-4425).
Deadline for manuscript submissions: 30 November 2014
Prof. Dr. Rozanne M. Sandri-Goldin
Department of Microbiology & Molecular Genetics, School of Medicine, University of California, Irvine, CA 92697, USA
Interests: ICP27; regulatory protein; HSV-1; mRNA processing; RNA export; RNA splicing; virus-host interactions
The journey of an RNA molecule that is destined to be translated into protein begins at its synthesis by RNA polymerase II through processing by the addition of a 5' cap, removal of introns, cleavage and polyadenylation of its 3' end, followed by its transport through nuclear pore complexes (NPC) in the nuclear membrane to reach the cytoplasm where it is translated. Growing evidence has revealed that mRNA export is linked to each of these steps, transcription, 5' capping, splicing and polyadenylation. Major players include the Transcription-Export or TREX complex, which associates with the 5' cap through the Cap Binding Complex; RNA export adaptor proteins like ALYREF and UIF, which form part of the TREX complex and bind to mRNA, and the mRNA receptor protein complex, TAP/NXF and p15, which guides the mRNP through the NPC. Nucleoporins, which line the NPC also play important roles in the transport of the mRNP complex through the NPC. Recent studies have also shown links between alterations in some TREX complex proteins and genome instability. Further, exploration into the functions of nucleoporins or Nups have shown that in addition to their roles in mRNA export, some Nups appear to function in transcription and genome arrangement. Finally, several viruses including the herpesviruses and Influenza virus have evolved mechanisms and encode proteins that hijack cellular mRNA export pathways to favor viral gene expression. Thus, the journey of mRNA from the nucleus to the cytoplasm is complex with many connections along the way.
Prof. Dr. Rozanne M. Sandri-Goldin
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- mRNA export
- Nuclear Pore Complex (NPC)
- TREX complex
- Nucleoporins (Nups)
- mRNA export adaptors