Special Issue "Mechanisms of mRNA Nuclear Export"


A special issue of Genes (ISSN 2073-4425).

Deadline for manuscript submissions: closed (30 November 2014)

Special Issue Editor

Guest Editor
Prof. Dr. Rozanne M. Sandri-Goldin
Department of Microbiology & Molecular Genetics, School of Medicine, University of California, Irvine, CA 92697, USA
E-Mail: rmsandri@uci.edu
Interests: ICP27; regulatory protein; HSV-1; mRNA processing; RNA export; RNA splicing; virus-host interactions

Special Issue Information

Dear Colleagues,

The journey of an RNA molecule that is destined to be translated into protein begins at its synthesis by RNA polymerase II through processing by the addition of a 5' cap, removal of introns, cleavage and polyadenylation of its 3' end, followed by its transport through nuclear pore complexes (NPC) in the nuclear membrane to reach the cytoplasm where it is translated. Growing evidence has revealed that mRNA export is linked to each of these steps, transcription, 5' capping, splicing and polyadenylation. Major players include the Transcription-Export or TREX complex, which associates with the 5' cap through the Cap Binding Complex; RNA export adaptor proteins like ALYREF and UIF, which form part of the TREX complex and bind to mRNA, and the mRNA receptor protein complex, TAP/NXF and p15, which guides the mRNP through the NPC. Nucleoporins, which line the NPC also play important roles in the transport of the mRNP complex through the NPC. Recent studies have also shown links between alterations in some TREX complex proteins and genome instability. Further, exploration into the functions of nucleoporins or Nups have shown that in addition to their roles in mRNA export, some Nups appear to function in transcription and genome arrangement. Finally, several viruses including the herpesviruses and Influenza virus have evolved mechanisms and encode proteins that hijack cellular mRNA export pathways to favor viral gene expression. Thus, the journey of mRNA from the nucleus to the cytoplasm is complex with many connections along the way.

Prof. Dr. Rozanne M. Sandri-Goldin
Guest Editor


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  • mRNA export
  • Nuclear Pore Complex (NPC)
  • TREX complex
  • TAP/NXF-p15
  • UIF
  • Nucleoporins (Nups)
  • mRNA export adaptors

Published Papers (3 papers)

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Displaying article 1-3
p. 1032-1049
by ,  and
Genes 2014, 5(4), 1032-1049; doi:10.3390/genes5041032
Received: 15 August 2014 / Revised: 2 October 2014 / Accepted: 20 October 2014 / Published: 11 November 2014
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(This article belongs to the Special Issue Mechanisms of mRNA Nuclear Export)
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p. 982-1000
by ,  and
Genes 2014, 5(4), 982-1000; doi:10.3390/genes5040982
Received: 6 August 2014 / Revised: 26 September 2014 / Accepted: 4 October 2014 / Published: 20 October 2014
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(This article belongs to the Special Issue Mechanisms of mRNA Nuclear Export)
p. 767-791
by  and
Genes 2014, 5(3), 767-791; doi:10.3390/genes5030767
Received: 25 July 2014 / Revised: 25 August 2014 / Accepted: 26 August 2014 / Published: 2 September 2014
Show/Hide Abstract | Cited by 1 | PDF Full-text (10614 KB) | HTML Full-text | XML Full-text
(This article belongs to the Special Issue Mechanisms of mRNA Nuclear Export)
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Last update: 10 June 2014

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