DNA Helicases: Mechanisms, Biological Pathways, and Disease Relevance

Dear Colleagues,

DNA helicases have emerged as a prominent class of nucleic acid metabolizing enzymes that play important roles in genome maintenance and cellular homeostasis. DNA helicases not only play essential roles in replication, DNA repair and recombination, they also influence gene expression and chromosome structure and act to resolve dynamic DNA structures that pose a source of genomic instability.

Although the basic mechanism of unwinding structured nucleic acids shares some basic commonality, research shows there are specialized DNA unwinding mechanisms that can be regulated by post-translational modifications and protein interactions.

With the discovery of genetic disorders linked to helicase gene mutations and various cancers associated with helicase defects, it has become more important than ever to characterize and document the molecular and cellular functions and pathways of DNA helicases to gain new understanding and move toward translational approaches in medicine.

This Special Issue of Genes will be dedicated to a compilation of articles on DNA helicases from leading experts in the field.

Dr. Robert Brosh
Guest Editor

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