Special Issue "Microfluidic Lab-on-a-Chip Platforms for High-Performance Diagnostics"
A special issue of Diagnostics (ISSN 2075-4418).
Deadline for manuscript submissions: closed (30 September 2012)
Microfluidic lab-on-a-chip technologies are commonly deemed a key enabler for high-performance future diagnostics. Amongst the techno-scientific advantages which are intrinsic to these miniaturised systems are: laminar flow conditions; enhanced, diffusion-advection controllable mixing and reaction kinetics; low sample and reagent volumes; availability of capillary flow and surface tension related effects; amenability for large-scale combinatorial assays; and scale matching on the micro-to-nano-range for large biomolecules and cells. On a system level, lab-on-a-chip technologies offer user-friendly sample-to-answer automation, single-use cartridges for potentially biohazardous samples, compact footprint, simplified instrumentation. These features empower use in decentralized point-of-care settings, for instance as portable devices in doctor’s offices, ambulances, patient self-testing at home and global diagnostics. Lab-on-a-chip platforms also bear a high potential to leverage next-generation companion diagnostics for personalized (stratified) medicine.
Dr. Jens Ducrée
- molecular diagnostics
- cell sorting