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Diagnostics 2013, 3(1), 126-154; doi:10.3390/diagnostics3010126
Review

When Medicine Meets Engineering—Paradigm Shifts in Diagnostics and Therapeutics

,  and *
Received: 10 December 2012; in revised form: 10 January 2013 / Accepted: 23 January 2013 / Published: 27 February 2013
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Abstract: During the last two decades, the manufacturing techniques of microfluidics-based devices have been phenomenally advanced, offering unlimited potential for bio-medical technologies. However, the direct applications of these technologies toward diagnostics and therapeutics are still far from maturity. The present challenges lay at the interfaces between the engineering systems and the biocomplex systems. A precisely designed engineering system with narrow dynamic range is hard to seamlessly integrate with the adaptive biological system in order to achieve the design goals. These differences remain as the roadblock between two fundamentally non-compatible systems. This paper will not extensively review the existing microfluidic sensors and actuators; rather, we will discuss the sources of the gaps for integration. We will also introduce system interface technologies for bridging the differences to lead toward paradigm shifts in diagnostics and therapeutics.
Keywords: microfluidic system; MEMS transducers; feedback system control (FSC); combinatorial drugs; network medicine microfluidic system; MEMS transducers; feedback system control (FSC); combinatorial drugs; network medicine
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Wang, H.; Silva, A.; Ho, C.-M. When Medicine Meets Engineering—Paradigm Shifts in Diagnostics and Therapeutics. Diagnostics 2013, 3, 126-154.

AMA Style

Wang H, Silva A, Ho C-M. When Medicine Meets Engineering—Paradigm Shifts in Diagnostics and Therapeutics. Diagnostics. 2013; 3(1):126-154.

Chicago/Turabian Style

Wang, Hann; Silva, Aleidy; Ho, Chih-Ming. 2013. "When Medicine Meets Engineering—Paradigm Shifts in Diagnostics and Therapeutics." Diagnostics 3, no. 1: 126-154.

Diagnostics EISSN 2075-4418 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert