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Exosomes and Extracellular Vesicles in Neuroprotection

A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 445

Special Issue Editor


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Guest Editor
1. Department of Pediatrics, Division of Neonatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
2. Department of Cell, Developmental and Integrative Biology, Division of Neonatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Interests: neonatology; exosomes; neuroprotection; extracellular vesicles; cell biology; brain; microglia
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

In the complex intercellular communication system, exosomes are a class of vesicles secreted from cells to the extracellular compartment, and their biogenesis mainly involves two invaginations of the cytoplasmic membrane, the formation of multiple vesicles, and the release of exosomes. Under normal or pathological conditions, exosomes are involved in the regulation of various signaling pathways through the delivery of various signaling molecules and play a role in the exchange of information between cells, which in turn affect the activity of recipient cells. 

In recent years, exosomes and extracellular vesicles have become biomarkers in the diagnosis and prognosis of different diseases, but also macromolecule delivery carriers for the treatment of various pathologies.

Therefore, exosomes can also be a target in the diagnosis as well as treatment of neurology-related diseases. The characterization of exosomes in the nervous system and the study of molecular mechanisms can help to deepen the understanding of exosomes in the nervous system and provide new clues for disease prevention and treatment. 

In this emerging and critical field, we invite experts to share their valuable insights, new data, or comprehensive systematic reviews.

You may choose our Joint Special Issue in IJMS.

Dr. Brian Sims
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Issues in Molecular Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • exosomes
  • extracellular vesicles
  • neuroprotection
  • central nervous system
  • brain
  • microglia
  • astrocytes and neurons

Published Papers (1 paper)

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Review

17 pages, 358 KiB  
Review
The Emerging Role of Human Gut Bacteria Extracellular Vesicles in Mental Disorders and Developing New Pharmaceuticals
by Effrosyni Louka and Vassiliki Lila Koumandou
Curr. Issues Mol. Biol. 2024, 46(5), 4751-4767; https://doi.org/10.3390/cimb46050286 - 15 May 2024
Viewed by 246
Abstract
In recent years, further evidence has emerged regarding the involvement of extracellular vesicles in various human physiopathological conditions such as Alzheimer’s disease, Parkinson’s disease, irritable bowel syndrome, and mental disorders. The biogenesis and cargo of such vesicles may reveal their impact on human [...] Read more.
In recent years, further evidence has emerged regarding the involvement of extracellular vesicles in various human physiopathological conditions such as Alzheimer’s disease, Parkinson’s disease, irritable bowel syndrome, and mental disorders. The biogenesis and cargo of such vesicles may reveal their impact on human health nd disease and set the underpinnings for the development of novel chemical compounds and pharmaceuticals. In this review, we examine the link between bacteria-derived exosomes in the gastrointestinal tract and mental disorders, such as depression and anxiety disorders. Crucially, we focus on whether changes in the gut environment affect the human mental state or the other way around. Furthermore, the possibility of handling bacteria-derived exosomes as vectors of chemicals to treat such conditions is examined. Full article
(This article belongs to the Special Issue Exosomes and Extracellular Vesicles in Neuroprotection)
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