Organellar Calcium Signaling in Physiology and Pathophysiology

Dear Colleagues,

Organellar function exists as a tightly regulated network of signalling cascades, each modulating different aspects of cellular physiology, from ATP synthesis to anti-oxidant defence systems and cell death. The function of these organelles is also influenced by the membrane composition and the structural organization and distribution of each organelle within the cell. However, despite the differences in the above-mentioned characteristics, organelles’ mode of action appears similar when they act as Ca²⁺-buffer and Ca²⁺-sensor factories. In response to various stimuli, organelles modulate Ca²⁺ signalling directly by importing Ca²⁺ via specific proteins embedded in the organellar membranes, or indirectly through the release of metabolites and messengers that can activate the Ca²⁺ signalling machinery. This intimate relationship between organelles and Ca²⁺ signalling lays the foundation for cellular decision-making, ultimately influencing cell survival. Therefore, given their importance in maintaining cellular homeostasis, any disturbance in the function of an organelle often results in the development of severe diseases, many of which have yet to be fully understood.

The aim of this Special Issue is to provide an overview summarizing our current knowledge regarding the underlying molecular mechanisms of organellar Ca²⁺ signalling in the context of normal cell physiology as well as disease, with special focus on the endoplasmic reticulum, lysosomes, and mitochondria.

Prof. Dr. Mohamed Trebak
Dr. Yassine El Hiani
Guest Editors

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• organellar Ca²⁺
• endoplasmic reticulum
• lysosomes
• mitochondria
• peroxisomes