Synaptic Dysfunction in the Progressive Neurodegeneration of Alzheimer’s Disease and Related Dementia

Dear Colleagues,

As you are aware, synaptic dysfunction is an early event associated with the progression of neurodegenerative states and can occur as a direct consequence of insult to the biochemical and structural components of neurons, especially in the presynaptic and postsynaptic compartments. Moreover, such structural changes may be observed at the dendritic spine levels and therefore become a common basis of studying the extent of progression of the neurodegenerative states. Additionally, aberrant changes in the function of astrocytes and microglia can also impinge on the neuronal function and affect the integrity of the synaptic transmission, thus increasing the importance of synaptic function studies as a basis for both understanding and treating neurodegenerative states. As a result, this Special Issue will highlight articles that cover all these aspects to uncover the kinds and types of mechanisms that are affected in health and disease.

Dr. Balaji Krishnan
Guest Editor

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• synapses
• dendrites
• neurons
• astrocytes
• microglia
• autophagy
• reactive oxygen species (ROS)
• amyloidogenic proteins (including Tau; Aβ; TDP-43; α-synuclein)
• AD/ADRD
• traumatic brain injury (TBI)