Angiogenesis in Cancer: Signalling Pathways of Angiogenesis

Dear Colleagues,

Tumors are characterized by rapid proliferation, heightened metabolism, and robust vitality, necessitating a greater supply of oxygen and nutrients compared to normal tissue cells. Tumor angiogenesis remains dormant or restricted due to low levels of pro-angiogenic factors and vascular inhibitory signals within the extracellular matrix, leading to minimal intratumoral vascularization. However, as the solid tumor expands beyond 1–2 mm, the surrounding tissue becomes inadequate to sustain its growth. This creates a microenvironment within the tumor characterized by hypoxia, ischemia, acidosis, and elevated interstitial pressure. In response, the tumor releases abundant growth factors and cytokines, triggering angiogenesis and lymphangiogenesis to support its metabolic demands. The rapid proliferation of tumor cells exacerbates this microenvironmental stress, leading to more severe hypoxia, acidosis, and increased interstitial pressure, particularly in regions distant from blood vessels within the tumor tissue. This promotes tumor enlargement and progression to a carcinoma stage, marked by heightened aggressiveness and the initiation of stromal responses, including intratumoral angiogenesis, leukocyte infiltration, fibroblast proliferation, and extracellular matrix deposition. With all of this in mind, this Special Issue focuses on elucidating the significant impacts of angiogenesis on various aspects of tumor biology, including growth, proliferation, carcinogenesis, invasion, and metastasis.

Dr. Stergios Boussios
Prof. Dr. Matin Sheriff
Guest Editor

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• angiogenesis
• cancer
• signal