Dear Colleagues,

Phase-transfer catalysis (PTC) began to develop in the 1960s and soon received widespread attention from academic and industrial chemists due to its simplicity and versatility. Today, it still represents a well-established procedure, widely employed in academic research and industrial applications, and is particularly attractive from an environmental and economic point of view. In particular, PTC is a powerful tool to carry out reactions with environmentally benign reagents and solvents under mild and safe reaction conditions, and is, therefore, a suitable methodology for practical synthesis on a scale capable to increase the process performance.

Particularly advantageous is the possibility to replace expensive solvents and dangerous bases such as sodium hydride, requiring strictly anhydrous conditions, with aqueous bases and apolar, environmentally friendly, easily recyclable solvents.

On the other hand, notable results have been obtained in asymmetric catalysis using chiral quaternary ammonium salts and, more recently, using chiral phosphate anions.

The goal of this Special Issue is to capture the interest of chemists who are not experts in the field to expand further the exploitation of PTC in organic synthesis. Both original papers and short reviews are welcome.

Dr. Domenico Albanese
Guest Editor

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• Phase transfer catalysis
• Organocatalysis
• Asymmetric catalysis
• Non-hazardous reagents
• Depollution
• Environmentally benign reagents
• Green chemistry
• Sustainable development