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Biosensors
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Biosensors for Organs-on-a-Chip Applications
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Biosensors for Organs-on-a-Chip Applications

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor Materials".

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 6991

Special Issue Editor

Dr. Trieu Nguyen

E-Mail Website
Guest Editor
Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, California Northstate University, Elk Grove, CA 95757, USA
Interests: point of care diagnostics; lab-on-a-chip; microfluidics; organs-on-chip
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Organs-on-a-chip were selected as one of the “Top Ten Emerging Technologies” at the World Economic Forum in 2016. Interest in biosensing for organs-on-a-chip applications have grown tremendously in the last few years. An organ-on-a-chip is a microfluidic cell culture device that simulates tissue- and organ-level physiology. By recreating an in vivo-like, physiological-relevant microenvironment, the device has great potential to overcome the limitations of conventional 2D or 3D culture systems. This technology can be applied to areas such as studying organ/tissue physiology, understanding disease etiology, and facilitating drug development. One of the important aspects of organ-on-a-chip is the integration and application of sensing technologies to provide reliable, high-content information on the physiological response of the device. To enable in situ continual monitoring of organ behaviors, a variety of biosensors have been integrated to detect organ-specific reactions and dynamic tissue responses. In this Special Issue, we focus on the integration of biosensors used for conveying and reading the information in organs-on-a-chip models of drug delivery, disease treatment, and personalized medicine.

As the guest editor of this Special Issue, I would like to thank the contributors in advance for their valuable time and for submitting papers of high quality. If you have any research in this field that you would like to publish please do get in touch.

Dr. Trieu Nguyen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biosensors
  • organs-on-a-chip
  • tissue engineering
  • microfluidics
  • biosensing
  • point-of-care
  • microfabrication
  • 3D printing
  • cell culture

Published Papers (2 papers)

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Research

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12 pages, 2481 KiB  
Article
Multicellular Cell Seeding on a Chip: New Design and Optimization towards Commercialization
by Trieu Nguyen, Linh Ho, Sakib M. Moinuddin, Tanoy Sarkar, Dipongkor Saha and Fakhrul Ahsan
Biosensors 2022, 12(8), 587; https://doi.org/10.3390/bios12080587 - 1 Aug 2022
Cited by 4 | Viewed by 2299
Abstract
This paper shows both experimental and in-depth theoretical studies (including simulations and analytical solutions) on a microfluidic platform to optimize its design and use for 3D multicellular co-culture applications, e.g., creating a tissue-on-chip model for investigating diseases such as pulmonary arterial hypertension (PAH). [...] Read more.
This paper shows both experimental and in-depth theoretical studies (including simulations and analytical solutions) on a microfluidic platform to optimize its design and use for 3D multicellular co-culture applications, e.g., creating a tissue-on-chip model for investigating diseases such as pulmonary arterial hypertension (PAH). A tissue microfluidic chip usually has more than two channels to seed cells and supply media. These channels are often separated by barriers made of micro-posts. The optimization for the structures of these micro-posts and their spacing distances is not considered previously, especially for the aspects of rapid and cost-efficient fabrication toward scaling up and commercialization. Our experimental and theoretical (COMSOL simulations and analytical solutions) results showed the followings: (i) The cell seeding was performed successfully for this platform when the pressure drops across the two posts were significantly larger than those across the channel width. The circular posts can be used in the position of hexagonal or other shapes. (ii) In this work, circular posts are fabricated and used for the first time. They offer an excellent barrier effect, i.e., prevent the liquid and gel from migrating from one channel to another. (iii) As for rapid and cost-efficient production, our computer-aided manufacturing (CAM) simulation confirms that circular-post fabrication is much easier and more rapid than hexagonal posts when utilizing micro-machining techniques, e.g., micro-milling for creating the master mold, i.e., the shim for polymer injection molding. The findings open up a possibility for rapid, cost-efficient, large-scale fabrication of the tissue chips using micro-milling instead of expensive clean-room (soft) lithography techniques, hence enhancing the production of biochips via thermoplastic polymer injection molding and realizing commercialization. Full article
(This article belongs to the Special Issue Biosensors for Organs-on-a-Chip Applications)
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Review

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17 pages, 1546 KiB  
Review
3D Printing in Solid Dosage Forms and Organ-on-Chip Applications
by Tarek Kassem, Tanoy Sarkar, Trieu Nguyen, Dipongkor Saha and Fakhrul Ahsan
Biosensors 2022, 12(4), 186; https://doi.org/10.3390/bios12040186 - 22 Mar 2022
Cited by 7 | Viewed by 3965
Abstract
3D printing (3DP) can serve not only as an excellent platform for producing solid dosage forms tailored to individualized dosing regimens but can also be used as a tool for creating a suitable 3D model for drug screening, sensing, testing and organ-on-chip applications. [...] Read more.
3D printing (3DP) can serve not only as an excellent platform for producing solid dosage forms tailored to individualized dosing regimens but can also be used as a tool for creating a suitable 3D model for drug screening, sensing, testing and organ-on-chip applications. Several new technologies have been developed to convert the conventional dosing regimen into personalized medicine for the past decade. With the approval of Spritam, the first pharmaceutical formulation produced by 3DP technology, this technology has caught the attention of pharmaceutical researchers worldwide. Consistent efforts are being made to improvise the process and mitigate other shortcomings such as restricted excipient choice, time constraints, industrial production constraints, and overall cost. The objective of this review is to provide an overview of the 3DP process, its types, types of material used, and the pros and cons of each technique in the application of not only creating solid dosage forms but also producing a 3D model for sensing, testing, and screening of the substances. The application of producing a model for the biosensing and screening of drugs besides the creation of the drug itself, offers a complete loop of application for 3DP in pharmaceutics. Full article
(This article belongs to the Special Issue Biosensors for Organs-on-a-Chip Applications)
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