Imprinting of Macromolecules

Dear Colleagues,

The field of Molecular Imprinting has rapidly expanded in the past 10–15 years. From its roots in the work of Mosbach, Shea and Wulff in the late 1970s to today, the idea of “artificial antibodies” continues to interest and intrigue researchers the world over. The sheer flexibility of imprinted materials makes them an obvious choice when considering replacements for biological recognition elements. MIPs (Molecularly Imprinted Polymers) have seen use in sensors, separations, catalysis and in several other fields.

The main focus of molecular imprinting has been to develop materials capable of selectively identifying small bioactives, or other compounds of interest—a task for which these materials are ideally suited. However, until recently the imprinting of proteins, or larger molecules, has only been considered by a few researchers (~1% of all literature) as there are inherent issues in the process, but this has not deterred researchers. Techniques such as targeting specific epitopes, utilising surface chemistry rather than traditional bulk imprinting and advances in nanoparticulates have seen the sub-field of protein/macromolecule imprinting expand rapidly.

This Special Issue is focused on the field of protein and macromolecular imprinting. Papers on any aspect of large molecule imprinting will be welcomed. Applications areas include sensors, cell labelling, separations, health analysis, or novel methodologies.

Dr. Nicholas W. Turner
Guest Editor

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• molecular imprinting
• protein imprinting
• protein detection
• biosensor
• epitope