Biosensors and Systems for Stem-Cells Electrostimulation

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor and Bioelectronic Devices".

Deadline for manuscript submissions: closed (31 August 2021) | Viewed by 3143

Special Issue Editors


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Guest Editor
Instituto de Microelectronica de Sevilla (US/IMSE), Universidad de Sevilla, 41004 Sevilla, Spain
Interests: atherosclerosis; cardiology; bioimpedance; stent; oscillation-based test
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Engineering and Materials Science and Transport, University of Seville (US), 41004 Seville, Spain
Interests: design and manufacture of porous materials; surface modification (physical and chemical); biofuntional (osseointegration, cells, and bacterial response) and tribo-mechanical (instrumented micro-indentation, fracture, fatigue, scratch resistance, and wear) behavior; biomaterials; tool materials (cemented carbides, cermet’s, and multi-layered: alumina-zirconia, WC-Co/WC-Co, and Cermet/WC-Co); powder metallurgy (conventional and space-holder technique)
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The development of stem cell-related technologies represent today a hot topic for research and companies involved in tissue engineering and regenerative medicine. New potential therapies and research areas can be promoted from the ability of optimum stem cells differentiation processes. Actual new sensing/actuation technologies based on biomaterials, electronic devices, microfluidic systems and micro-electro-mechanical systems (MEMs) open up new biomedical opportunities to measure and actuate “better”, with “alternative” methods to explore and find the insight information pursuit for physician and biologist teams, for diagnosis, therapy, clinical tests and bio-signal monitoring.  The accomplishment of new medical techniques for specific assays and tests in the health field provides significant challenges in the biomaterials, microfluidic, electronic circuits and systems required, whose performance is vital for proper and accurate lab tasks. This Special Issue is devoted principally to incorporating new proposals for stem cell development technologies, mainly based on electrostimulation signals based on new circuits and systems approaches, and its actuation effect for optimization cell differentiation.

In general, it is focused on the new electrostimulation setups, electrode layout design and biomaterial selection involved, bio-signal analog front-end (AFE) circuits; specific circuits development for known and new sensor/sensing approaches; circuits for biomedical signal processing; devices; circuits and systems for clinical applications; circuits for sensing/actuation in MEM systems, lab-on-a-chip (LoC), micro-total-analysis systems (uTAS); cell assays and manipulation, etc. Tissue engineering and regenerative medicine. The main topics of interest include, but are not limited to:

  • Electrostimulation techniques (AC/DC) and circuits
  • Design, manufacture and characterization of new biomaterials
  • 2D and 3D electrode design
  • Stem cell culture
  • Differentiation
  • Analog Front-End (AFE) circuits
  • Cells, stem cells and tissue electrical models
  • Bioimpedance and capacitive based circuits
  • Circuits for new sensing/monitoring devices and microelectrodes
  • Circuits, systems and MEMs in stem cell clinical applications
  • Tissue engineering applications: N2A, myoblast, osteoblast and others
  • Other biosensors: chemical, optical, mechanical

Dr. Alberto Yufera
Prof. Dr. Yadir Torres Hernández
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • electrostimulation
  • biomaterials
  • real time monitoring
  • Analog Front-End (AFE) circuits
  • bioimpedance
  • microelectrodes and MEAs
  • biosensors
  • Lab-on-a-Chip (LoC)
  • circuits and systems in clinical applications
  • circuits for cell, DNA, bacteria, virus, etc. assays
  • cell electric models
  • tissue engineering
  • regenerative medicine

Published Papers (1 paper)

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Research

13 pages, 2513 KiB  
Article
Real-Time Monitoring of Levetiracetam Effect on the Electrophysiology of an Heterogenous Human iPSC-Derived Neuronal Cell Culture Using Microelectrode Array Technology
by Andrea Di Credico, Giulia Gaggi, Pascal Izzicupo, Laura Ferri, Laura Bonanni, Giovanni Iannetti, Angela Di Baldassarre and Barbara Ghinassi
Biosensors 2021, 11(11), 450; https://doi.org/10.3390/bios11110450 - 12 Nov 2021
Cited by 8 | Viewed by 2434
Abstract
Levetiracetam (LEV) is a broad-spectrum and widely used antiepileptic drug that also has neuroprotective effects in different neurological conditions. Given its complex interaction with neuronal physiology, a better comprehension of LEV effects on neurons activity is needed. Microelectrode arrays (MEAs) represent an advanced [...] Read more.
Levetiracetam (LEV) is a broad-spectrum and widely used antiepileptic drug that also has neuroprotective effects in different neurological conditions. Given its complex interaction with neuronal physiology, a better comprehension of LEV effects on neurons activity is needed. Microelectrode arrays (MEAs) represent an advanced technology for the non-invasive study of electrophysiological activity of neuronal cell cultures. In this study, we exploited the Maestro Edge MEA system, a platform that allows a deep analysis of the electrical network behavior, to study the electrophysiological effect of LEV on a mixed population of human neurons (glutamatergic, GABAergic and dopaminergic neurons, and astrocytes). We found that LEV significantly affected different variables such as spiking, single-electrode bursting, and network bursting activity, with a pronounced effect after 15 min. Moreover, neuronal cell culture completely rescued its baseline activity after 24 h without LEV. In summary, MEA technology confirmed its high sensitivity in detecting drug-induced electrophysiological modifications. Moreover, our results allow one to extend the knowledge on the electrophysiological effects of LEV on the complex neuronal population that resembles the human cortex. Full article
(This article belongs to the Special Issue Biosensors and Systems for Stem-Cells Electrostimulation)
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