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Biosensors
Special Issues
Biosensors for MicroTAS
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Biosensors for MicroTAS

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".

Deadline for manuscript submissions: closed (31 March 2022) | Viewed by 7455

Special Issue Editors

Dr. Yaxiaer Yalikun

E-Mail Website
Guest Editor
Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan
Interests: biosensors; signal measurement; biorobotics; micro devices; MEMS sensors; glass micro fluidicsdevice; micro fabrication
Special Issues, Collections and Topics in MDPI journals
Dr. Yoshitake Akiyama

E-Mail Website
Guest Editor
Graduate School of Science and Technology, Shinshu University, Ueda, Nagano 386-8567, Japan
Interests: microfluidics; mechanics; cell devices; electronics; analytical chemsitry
Dr. Ming Li

E-Mail Website
Guest Editor
School of Engineering, Macquarie University, Sydney, NSW 2122, Australia
Interests: biomicrofluidics; plasmonic biosensors; droplet microfluidics; lab-on-a-chip devices; cytometry
Special Issues, Collections and Topics in MDPI journals
Dr. Dahai Ren

E-Mail Website
Guest Editor
Department of Precision Instruments, Tsinghua University, Beijing 100084, China
Interests: biological micro system; micro-nano sensors; MEMS device

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to this Special Issue on Biosensors for MicroTAS, which are emerging research subjects with various applications from the macro to the micro scale. MicroTAS is a multidisciplinary field involving the design, construction, fabrication, operation, and use of robots/devices/instruments for diagnostic, evaluation, measurement, rapid detection in food safety, chemical, biological, medical diagnostic, and environmental monitoring applications.

This Special Issue will focus on novel applications and methodologies in the field of microTAS for fully exploring the limitations of biosensor technology, including, but not limited to:

  • automation of lab-on-a-chip and other biochip and microarray systems;
  • on-chip measurement, evaluation, analysis, and detection for microTAS purposes;
  • the development of biosensor methodologies and applications;
  • methods for the fabrication of chip-based detection devices;
  • biophotonic sensors and chemical sensing systems;
  • novel biological and chemical sensors, including smart materials and microfluidic components; and
  • advanced bionics sensors.

Dr. Yaxiaer Yalikun
Dr. Yoshitake Akiyama
Dr. Ming Li
Dr. Dahai Ren
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lab-on-a-chip
  • biochips
  • biophotonic sensors
  • microfluidics
  • chemical sensing
  • microarrays

Published Papers (2 papers)

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Research

14 pages, 2932 KiB  
Article
Focusing of Particles in a Microchannel with Laser Engraved Groove Arrays
by Tianlong Zhang, Yigang Shen, Ryota Kiya, Dian Anggraini, Tao Tang, Hanaka Uno, Kazunori Okano, Yo Tanaka, Yoichiroh Hosokawa, Ming Li and Yaxiaer Yalikun
Biosensors 2021, 11(8), 263; https://doi.org/10.3390/bios11080263 - 4 Aug 2021
Cited by 7 | Viewed by 2908
Abstract
Continuous microfluidic focusing of particles, both synthetic and biological, is significant for a wide range of applications in industry, biology and biomedicine. In this study, we demonstrate the focusing of particles in a microchannel embedded with glass grooves engraved by femtosecond pulse (fs) [...] Read more.
Continuous microfluidic focusing of particles, both synthetic and biological, is significant for a wide range of applications in industry, biology and biomedicine. In this study, we demonstrate the focusing of particles in a microchannel embedded with glass grooves engraved by femtosecond pulse (fs) laser. Results showed that the laser-engraved microstructures were capable of directing polystyrene particles and mouse myoblast cells (C2C12) towards the center of the microchannel at low Reynolds numbers (Re < 1). Numerical simulation revealed that localized side-to-center secondary flows induced by grooves at the channel bottom play an essential role in particle lateral displacement. Additionally, the focusing performance proved to be dependent on the angle of grooves and the middle open space between the grooves based on both experiments and simulation. Particle sedimentation rate was found to critically influence the focusing of particles of different sizes. Taking advantage of the size-dependent particle lateral displacement, selective focusing of micrometer particles was demonstrated. This study systematically investigated continuous particle focusing in a groove-embedded microchannel. We expect that this device will be used for further applications, such as cell sensing and nanoparticle separation in biological and biomedical areas. Full article
(This article belongs to the Special Issue Biosensors for MicroTAS)
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9 pages, 2669 KiB  
Article
Inertial-Assisted Immunomagnetic Bioplatform towards Efficient Enrichment of Circulating Tumor Cells
by Yixing Gou, Jiawen Liu, Changku Sun, Peng Wang, Zheng You and Dahai Ren
Biosensors 2021, 11(6), 183; https://doi.org/10.3390/bios11060183 - 5 Jun 2021
Cited by 9 | Viewed by 3378
Abstract
Serving as an effective biomarker in liquid biopsy, circulating tumor cells (CTCs) can provide an accessible source for cancer biology study. For the in-depth evaluation of CTCs in cancer analysis, their efficient enrichment is essential, owing to their low abundance in peripheral blood. [...] Read more.
Serving as an effective biomarker in liquid biopsy, circulating tumor cells (CTCs) can provide an accessible source for cancer biology study. For the in-depth evaluation of CTCs in cancer analysis, their efficient enrichment is essential, owing to their low abundance in peripheral blood. In this paper, self-assembled immunomagnetic beads were developed to isolate CTCs from the ordered bundles of cells under the assistance of the spiral inertial effect. Parametric numerical simulations were performed to explore the velocity distribution in the cross section. Based on this chip, rare CTCs could be recovered under the throughput of 500 μL/min, making this device a valuable supplement in cancer analysis, diagnostics, and therapeutics. Full article
(This article belongs to the Special Issue Biosensors for MicroTAS)
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