Field-Effect Transistor-Based Biosensors

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor and Bioelectronic Devices".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 1442

Special Issue Editor


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Guest Editor
Immunotherapy Research Center, Korea Research of Institute Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of Korea
Interests: field-effect transistor; graphene; POCT; portable biosensors; microfluidics; photonic PCR
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Special Issue Information

Dear Colleagues,

Field-effect transistors (FETs) as biosensors are utilized for detection and monitoring by using various materials, carbon-, and polymer-based materials. Recently, FETs-based biosensors were utilized for immune diagnosis owing to the COVID-19 pandemic, and have been developed for the detection of infectious pathogens. In particular, FETs-based biosensors integrated with a chip are required for the improvement of lab-on-a-chip technology, enabling an efficient, rapid, and cost-effective point-of-care diagnosis. These miniaturized FET-based biosensors can detect biomarkers, proteins, and nucleic acids with high sensitivity and specificity. Lab-on-a-chip platforms incorporating FET biosensors have revolutionized healthcare by providing real-time, on-site diagnostics, reducing the need for centralized laboratories, and minimizing turnaround times. This advancement is pivotal in remote and resource-limited areas, ensuring timely disease detection and management. FET-based biosensors on lab-on-a-chip devices are poised to play a critical role in personalized medicine, early disease detection, and continuous health monitoring, making them indispensable tools in the future of healthcare.

Accordingly, this Special Issue seeks to showcase research papers, short communications, and review articles that focus on the following topics: (1) field-effect transistor platform development for biosensors using new technologies; (2) lab-on-a-chip-based FET platform for rapid detection and diagnosis; and (3) a point-of-care diagnosis system for on-site application etc.

Dr. Kyung Ho Kim
Guest Editor

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Keywords

  • POCT
  • biosensors
  • nanotechnology
  • field-effect transistor (FET)
  • lab-on-a-chip
  • portable device

Published Papers (1 paper)

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Research

13 pages, 2317 KiB  
Article
Rapid and Easy Detection of Microcystin-LR Using a Bioactivated Multi-Walled Carbon Nanotube-Based Field-Effect Transistor Sensor
by Myeongsoon Lee, Seong H. Kim, Don Kim and Hak Jun Kim
Biosensors 2024, 14(1), 37; https://doi.org/10.3390/bios14010037 - 11 Jan 2024
Viewed by 1175
Abstract
In this study, we developed a multi-walled carbon nanotube (MWCNT)-based field-effect transistor (MWCNT-FET) sensor with high sensitivity and selectivity for microcystin-LR (MC-LR). Carboxylated MWCNTs were activated with an MC-LR-targeting aptamer (MCTA). Subsequently the bioactivated MWCNTs were immobilized between interdigitated drain (D) and source [...] Read more.
In this study, we developed a multi-walled carbon nanotube (MWCNT)-based field-effect transistor (MWCNT-FET) sensor with high sensitivity and selectivity for microcystin-LR (MC-LR). Carboxylated MWCNTs were activated with an MC-LR-targeting aptamer (MCTA). Subsequently the bioactivated MWCNTs were immobilized between interdigitated drain (D) and source (S) electrodes through self-assembly. The top-gated MWCNT-FET sensor was configured by dropping the sample solution onto the D and S electrodes and immersing a Ag/AgCl electrode in the sample solution as a gate (G) electrode. We believe that the FET sensor’s conduction path arises from the interplay between the MCTAs, with the applied gate potential modulating this path. Using standard instruments and a personal computer, the sensor’s response was detected in real-time within a 10 min time frame. This label-free FET sensor demonstrated an impressive detection capability for MC-LR in the concentration range of 0.1–0.5 ng/mL, exhibiting a lower detection limit of 0.11 ng/mL. Additionally, the MWCNT-FET sensor displayed consistent reproducibility, a robust selectivity for MC-LR over its congeners, and minimal matrix interferences. Given these attributes, this easily mass-producible FET sensor is a promising tool for rapid, straightforward, and sensitive MC-LR detection in freshwater environments. Full article
(This article belongs to the Special Issue Field-Effect Transistor-Based Biosensors)
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