Biosensors

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Special Issue Editors

Dr. Marco Aurélio Suller Garcia

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Guest Editor

Departamento de Química, Centro de Ciências Exatas e Tecnologias, Universidade Federal do Maranhão (UFMA), Av. dos Portugueses, 1966 Vila Bacanga, São Luís 65080-805, MA, Brazil
Interests: coordination chemistry; nanomaterials; materials science

Dr. Andre Henrique Baraldi Dourado

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Guest Editor

Instituto de Química, Universidade Estadual Paulista, São Paulo, Brazil
Interests: physical chemistry

Special Issue Information

Dear Colleagues,

Nanocomposite-based biosensors have emerged as a promising platform for sensitive, selective, and rapid detection of a wide range of analytes in various fields, including healthcare, environmental monitoring, food safety, and diagnostics. Integrating nanomaterials with biorecognition elements has revolutionized the field of biosensing by enhancing the performance and functionality of sensing devices. This Special Issue aims to highlight the recent advances and perspectives in the development and application of nanocomposite-based biosensors.

Topics of interest for this Special Issue include, but are not limited to:

Design and synthesis of novel nanocomposite materials for biosensing applications.
Development of nanocomposite-based platforms for point-of-care diagnostics.
Integration of nanocomposites with biofunctional molecules (e.g., enzymes, antibodies, and aptamers) for enhanced biosensing.
Fabrication and characterization of nanocomposite-based sensors.
Applications of nanocomposite-based biosensors in healthcare, environmental monitoring, food safety, and other relevant fields.
Advances in signal amplification and signal transduction mechanisms in nanocomposite-based biosensors.
Biocompatibility and biostability of nanocomposite materials for long-term biosensing applications.
Challenges and future perspectives in the development of nanocomposite-based biosensors.

Authors are invited to submit original research articles, reviews, and perspectives that address the topics mentioned above or other related areas within the scope of this Special Issue. Submissions should present novel findings, or experimental or theoretical approaches, and demonstrate the potential impact of nanocomposite-based biosensors in advancing the field of biosensing.

Dr. Marco Aurélio Suller Garcia
Dr. Andre Henrique Baraldi Dourado
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

nanocomposite-based biosensors
point-of-care diagnostics
biofunctional molecules
environmental monitoring
food safety

Published Papers (2 papers)

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Research

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16 pages, 4524 KiB

Open AccessArticle

Reduced Graphene Oxide/Organic Dye Composites for Bioelectroconversion of Saccharides: Application for Detection of Saccharides and α-Amylase Assessments

by Marius Butkevicius, Justina Gaidukevic, Vidute Gureviciene and Julija Razumiene

Biosensors 2023, 13(12), 1020; https://doi.org/10.3390/bios13121020 - 8 Dec 2023

Viewed by 1362

Abstract

In this study, PQQ-dependent glucose dehydrogenase (PQQ-GDH) was immobilized onto reduced graphene oxide (rGO) modified with organic dyes from three different classes (acridine, arylmethane, and diazo); namely, neutral red (NR), malachite green (MG), and congo red (CR) formed three types of biosensors. All three rGO/organic dye composites were characterized by scanning electron microscopy, X-ray photoelectron spectroscopy, and Raman spectroscopy. The impact of three rGO/organic dye modifications employed in bioelectrocatalytic systems on changes in enzyme activity and substrate selectivity was investigated. The highest sensitivity of 39 µA/cm² was obtained for 1 mM of glucose when a rGO_MG/PQQ-GDH biosensor was used. A significant improvement in the electrochemical response of biosensors was attributed to the higher amount of pyrrolic nitrogen groups on the surface of the rGO/organic dye composites. Modifications of rGO by NR and MG not only improved the surfaces for efficient direct electron transfer (DET) but also influenced the enzyme selectivity through proper binding and orientation of the enzyme. The accuracy of the biosensor’s action was confirmed by the spectrophotometric analysis. Perspectives for using the proposed bioelectrocatalytic systems operating on DET principles for total or single monosaccharide and/or disaccharide determination/bioconversion systems or for diagnoses have been presented through examples of bioconversion of D-glucose, D-xylose, and maltose. Full article

(This article belongs to the Special Issue Nanocomposite-Based Biosensors: Recent Advances and Perspectives)

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Graphical abstract

Review

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23 pages, 4321 KiB

Open AccessReview

Low-Cost Plant-Based Metal and Metal Oxide Nanoparticle Synthesis and Their Use in Optical and Electrochemical (Bio)Sensors

by Iulia Corina Ciobotaru, Daniela Oprea, Constantin Claudiu Ciobotaru and Teodor Adrian Enache

Biosensors 2023, 13(12), 1031; https://doi.org/10.3390/bios13121031 - 15 Dec 2023

Viewed by 1517

Abstract

Technological progress has led to the development of analytical tools that promise a huge socio-economic impact on our daily lives and an improved quality of life for all. The use of plant extract synthesized nanoparticles in the development and fabrication of optical or electrochemical (bio)sensors presents major advantages. Besides their low-cost fabrication and scalability, these nanoparticles may have a dual role, serving as a transducer component and as a recognition element, the latter requiring their functionalization with specific components. Different approaches, such as surface modification techniques to facilitate precise biomolecule attachment, thereby augmenting recognition capabilities, or fine tuning functional groups on nanoparticle surfaces are preferred for ensuring stable biomolecule conjugation while preserving bioactivity. Size optimization, maximizing surface area, and tailored nanoparticle shapes increase the potential for robust interactions and enhance the transduction. This article specifically aims to illustrate the adaptability and effectiveness of these biosensing platforms in identifying precise biological targets along with their far-reaching implications across various domains, spanning healthcare diagnostics, environmental monitoring, and diverse bioanalytical fields. By exploring these applications, the article highlights the significance of prioritizing the use of natural resources for nanoparticle synthesis. This emphasis aligns with the worldwide goal of envisioning sustainable and customized biosensing solutions, emphasizing heightened sensitivity and selectivity. Full article

(This article belongs to the Special Issue Nanocomposite-Based Biosensors: Recent Advances and Perspectives)

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