Sulfide and Redox Regulation

Dear Colleagues,

Nature has exploited the rich chemistry of sulfur to maintain reducing cellular content in a rather oxidizing environment. Sulfur compounds constitute the major players in cellular redox mechanisms across species from unicellular organisms to mammals. From neutralization of reactive oxygen and nitrogen species to signaling events, the scope of cellular processes regulated by sulfur-based chemistry is expanding with the recent findings and characterization of new sulfur species produced endogenously that were previously considered toxic or belonging to bacterial world. Mounting reports describe the role of sulfur metabolism in healthy and diseased states and maintenance of tissue homeostasis, which stimulated development of therapeutic approaches to treat diseases involving cardiovascular, neuronal, and immune systems as well as efforts to deliver sulfur species for treatment with multiple clinical trials already underway. However, there is still hard work ahead to conquer technical challenges in characterizing and measuring sulfur-based metabolites in cells and tissues.

In this Special Issue, we welcome original research manuscripts and reviews spanning a range of topics from chemistry and metabolism of sulfur compounds to cell biology and physiology delineating sulfur-based mechanisms in redox regulation, characterization and the role of sulfur metabolites in biological processes and signaling events, diseases and animal model studies, pharmacological effects of sulfur metabolites and drug development.

Dr. Omer Kabil
Dr. Carmen Gherasim
Guest Editors

Manuscript Submission Information

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