Implication of Oxidative Stress in Promoting Cellular Senescence and Associated Pathologies—2nd Edition

Dear Colleagues,

Cellular responses to reactive oxygen species (ROS) depend on the nature, the level, the duration, and the cells’ ability to cope with the oxidant stimulus to which they are exposed. Basic steady-state levels of ROS oxidize specific targets and regulate the signaling pathways implicated in various physiological processes (redox signaling). However, deviation from this steady state leads to unspecific oxidation, thus disrupting redox signaling and/or causing macromolecular damage. Depending on the severity of the damage, cell responses can range from permanent growth arrest (cellular senescence) to programmed cell death (apoptosis or ferroptosis), or, in more extreme conditions, necrotic cell death.

Cellular senescence, as a stable growth arrest program, has evolved as a mechanism to prevent the propagation of unwanted cells. Yet, senescent cells are not inert; despite the accelerated accumulation of macromolecular damage, they remain alive for prolonged periods and release factors that can harm neighboring healthy cells, as well as the very cells that produce these factors. Accordingly, their accumulation within tissues and organs contributes to tissue dysfunction and gives rise to pathological manifestations, organ ageing, and age-related diseases.

In this regard, unraveling the underlying mechanisms of oxidative stress-induced cellular senescence will contribute significantly to the development of new strategies combatting ageing and age-related pathologies. This Special Issue aims to elucidate the interrelationships of oxidative stress and cellular senescence and their contribution to ageing and age-related pathologies.

We look forward to receiving your contributions.

Dr. Alexandra Barbouti
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• oxidative stress
• free radicals
• reactive oxygen species (ROS)
• cellular senescence
• ageing
• age-related pathologies