Special Issue "Natural Killer (NK) Cells"
A special issue of Antibodies (ISSN 2073-4468).
Deadline for manuscript submissions: closed (31 October 2013)
Dr. Taku Kambayashi
Division of Transfusion Medicine and Therapeutic Pathology, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA
Interests: mouse NK cell education; inhibitory receptors; activating receptors; signal transduction; cytotoxicity
Natural killer (NK) cells play an important role in defense against tumors and infections. When activated, NK cells can produce proinflammatory cytokines and directly eradicate tumor or pathogen-infected cells by mediating cytotoxicity. One important mechanism by which NK cells recognize target cells is through interaction of their Fcγ receptor with IgG-coated targeted cells or IgG immune complexes. Ligation of the Fcγ receptor involves the phosphorylation of immunotyrosine-based activation motif (ITAM)s in the intracellular portion of the Fcγ chain leading to downstream signal transduction events important for NK cell responses. Activation through ITAM-bearing immunoreceptors is critical for NK cell development and function in pathological and non-pathological states.
This special issue of Antibodies is focused on NK cell activation through Fcγ receptors or by other immunoreceptors utilizing ITAM-bearing adaptors and I kindly invite you to submit your novel results to this special issue. Welcome are manuscripts describing in vitro or in vivo function of NK cells activated through these receptors, signal transduction through these receptors, and acquisition or effects of these receptors in NK cell development or homeostasis.
Dr. Taku Kambayashi
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibodies is an international peer-reviewed Open Access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 300 CHF (Swiss Francs). English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.
- NK cells
- Fcγ receptor
- antibody-dependent cellular cytotoxicity (ADCC)
- signal transduction
- NK cell development
- NK cell effector function