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Antibodies 2014, 3(1), 1-15; doi:10.3390/antib3010001

The Role of CD2 Family Members in NK-Cell Regulation of B-Cell Antibody Production

Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Received: 16 October 2013 / Revised: 13 December 2013 / Accepted: 13 December 2013 / Published: 19 December 2013
(This article belongs to the Special Issue Natural Killer (NK) Cells)
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Natural Killer (NK) cells, an important component of the innate immune system, can mount much more rapid responses upon activation than adaptive antigen specific responses. Among the various functions attributed to NK cells their effect on antibody production merits special attention. The modification of IgG subclasses distribution as well as the amplification of the B cell response can be functionally relevant both for mediation of antibody-dependent cellular cytotoxicity (ADCC) and for control of dysregulated autoantibody production. In this review recent experimental evidence for the mechanistic basis of the effect of NK cells on B cell-responses will be covered. Thus, it will be shown that these effects are mediated not only via activation of cytokine and Toll-like receptors (TLR), but also by direct receptor-ligand interactions. Importantly, the function of these receptor/ligands, CD48 and CD244, do not require recognition of class I-MHC molecules but are more dependent on inflammatory conditions brought about by infection or oncogenesis.
Keywords: NK cells; B lymphocytes; CD244; CD48; TLR7 NK cells; B lymphocytes; CD244; CD48; TLR7
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Yuan, D. The Role of CD2 Family Members in NK-Cell Regulation of B-Cell Antibody Production. Antibodies 2014, 3, 1-15.

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