Recent Progress in the Microbial Production of Pyruvic Acid
AbstractPyruvic acid (pyruvate) is a cellular metabolite found at the biochemical junction of glycolysis and the tricarboxylic acid cycle. Pyruvate is used in food, cosmetics, pharmaceutical and agricultural applications. Microbial production of pyruvate from either yeast or bacteria relies on restricting the natural catabolism of pyruvate, while also limiting the accumulation of the numerous potential by-products. In this review we describe research to improve pyruvate formation which has targeted both strain development and process development. Strain development requires an understanding of carbohydrate metabolism and the many competing enzymes which use pyruvate as a substrate, and it often combines classical mutation/isolation approaches with modern metabolic engineering strategies. Process development requires an understanding of operational modes and their differing effects on microbial growth and product formation. View Full-Text
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Maleki, N.; Eiteman, M.A. Recent Progress in the Microbial Production of Pyruvic Acid. Fermentation 2017, 3, 8.
Maleki N, Eiteman MA. Recent Progress in the Microbial Production of Pyruvic Acid. Fermentation. 2017; 3(1):8.Chicago/Turabian Style
Maleki, Neda; Eiteman, Mark A. 2017. "Recent Progress in the Microbial Production of Pyruvic Acid." Fermentation 3, no. 1: 8.
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