Table of Contents
Bioengineering, Volume 5, Issue 2 (June 2018)
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Cover Story (view full-size image) There is an evident need to screen for the toxicity and efficacy of drugs and cosmetics applied to [...] Read more. There is an evident need to screen for the toxicity and efficacy of drugs and cosmetics applied to the skin. Multi-organ chips are an attractive alternative to animal testing. Among them, the two-organ chip is designed to hold 96-well cell culture inserts for testing small-sized skin equivalents. Here, full-thickness skin equivalents were generated inside these 96-well culture inserts and were successfully integrated into a two-organ chip. This system was employed to implement permeation in a computational fluid dynamics simulation. The results support its use in long-term permeation studies. View Paper here.