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Bioengineering 2018, 5(2), 28; https://doi.org/10.3390/bioengineering5020028

Therapeutic Use of Stem Cells for Myocardial Infarction

1
Northern Ontario School of Medicine, Sudbury, ON P3E 2C6, Canada
2
Health Sciences North, Sudbury, ON P3E 5J1, Canada
*
Author to whom correspondence should be addressed.
Received: 1 March 2018 / Revised: 29 March 2018 / Accepted: 4 April 2018 / Published: 6 April 2018
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Abstract

Myocardial infarction is a leading cause of morbidity and mortality worldwide. Although medical and surgical treatments can significantly improve patient outcomes, no treatment currently available is able to generate new contractile tissue or reverse ischemic myocardium. Driven by the recent/novel understanding that regenerative processes do exist in the myocardium—tissue previously thought not to possess regenerative properties—the use of stem cells has emerged as a promising therapeutic approach with high expectations. The literature describes the use of cells from various sources, categorizing them as either embryonic, induced pluripotent, or adult/tissue stem cells (mesenchymal, hematopoietic, skeletal myoblasts, cardiac stem cells). Many publications show the successful use of these cells to regenerate damaged myocardium in both animal and human models; however, more studies are needed to directly compare cells of various origins in efforts to draw conclusions on the ideal source. Although numerous challenges exist in this developing area of research and clinical practice, prospects are encouraging. The following aims to provide a concise review outlining the different types of stem cells used in patients after myocardial infarction. View Full-Text
Keywords: stem cell therapy; myocardial infarction; bone marrow; mesenchymal stem cells; hematopoietic stem cells; embryonic stem cells; induced pluripotent stem cells; cardiac stem cells stem cell therapy; myocardial infarction; bone marrow; mesenchymal stem cells; hematopoietic stem cells; embryonic stem cells; induced pluripotent stem cells; cardiac stem cells
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Madigan, M.; Atoui, R. Therapeutic Use of Stem Cells for Myocardial Infarction. Bioengineering 2018, 5, 28.

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