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Bioengineering 2018, 5(2), 37; https://doi.org/10.3390/bioengineering5020037

Anti-RSV Peptide-Loaded Liposomes for the Inhibition of Respiratory Syncytial Virus

1
Center for NanoBiotechnology Research, Alabama State University, Montgomery, AL 36016, USA
2
Aston Pharmacy School, Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
3
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK
This paper is an extended version of our paper published in conference proceedings of TechConnect, 2017
*
Author to whom correspondence should be addressed.
Received: 5 February 2018 / Revised: 29 April 2018 / Accepted: 7 May 2018 / Published: 9 May 2018
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Abstract

Although respiratory syncytial virus (RSV) is one of the leading causes of acute respiratory tract infection in infants and adults, effective treatment options remain limited. To circumvent this issue, there is a novel approach, namely, the development of multifunctional liposomes for the delivery of anti RSV-peptides. While most of the peptides that are used for loading with the particulate delivery systems are the penetrating peptides, an alternative approach is the development of liposome-peptide systems, which are loaded with an RSV fusion peptide (RF-482), which has been designed to inhibit the RSV fusion and block infection. The results of this work have revealed that the liposomes themselves can serve as potential RSV inhibitors, whilst the anti-RSV-peptide with liposomes can significantly increase the RSV inhibition when compared with the anti-RSV peptide alone. View Full-Text
Keywords: liposomes; respiratory syncytial virus; peptide; hydrophilic liposomes; respiratory syncytial virus; peptide; hydrophilic
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Joshi, S.; Chaudhari, A.A.; Dennis, V.; Kirby, D.J.; Perrie, Y.; Singh, S.R. Anti-RSV Peptide-Loaded Liposomes for the Inhibition of Respiratory Syncytial Virus. Bioengineering 2018, 5, 37.

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