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Processes 2014, 2(1), 58-70; doi:10.3390/pr2010058

Scale-up of the Reversible Addition-Fragmentation Chain Transfer (RAFT) Polymerization Using Continuous Flow Processing

1 CSIRO Materials Science and Engineering, Bayview Avenue, Clayton, VIC 3168, Australia 2 Chemical Engineering Faculty, Monash University, Wellington Road, Clayton, VIC 3169, Australia These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 7 November 2013 / Revised: 10 December 2013 / Accepted: 12 December 2013 / Published: 8 January 2014
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A controlled radical polymerization process using the Reversible Addition-Fragmentation Chain Transfer (RAFT) approach was scaled up by a factor of 100 from a small laboratory scale of 5 mL to a preparative scale of 500 mL, using batch and continuous flow processing. The batch polymerizations were carried out in a series of different glass vessels, using either magnetic or overhead stirring, and different modes of heating: Microwave irradiation or conductive heating in an oil bath. The continuous process was conducted in a prototype tubular flow reactor, consisting of 6 mm ID stainless steel tubing, fitted with static mixers. Both reactor types were tested for polymerizations of the acid functional monomers acrylic acid and 2-acrylamido-2-methylpropane-1-sulfonic acid in water at 80 °C with reaction times of 30 to 40 min. By monitoring the temperature during the exothermic polymerization process, it was observed that the type and size of reactor had a significant influence on the temperature profile of the reaction.
Keywords: RAFT polymerization; continuous flow; scale-up RAFT polymerization; continuous flow; scale-up
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Micic, N.; Young, A.; Rosselgong, J.; Hornung, C.H. Scale-up of the Reversible Addition-Fragmentation Chain Transfer (RAFT) Polymerization Using Continuous Flow Processing. Processes 2014, 2, 58-70.

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