Next Article in Journal
Model-Based Optimization of Scaffold Geometry and Operating Conditions of Radial Flow Packed-Bed Bioreactors for Therapeutic Applications
Next Article in Special Issue
Scale-up of the Reversible Addition-Fragmentation Chain Transfer (RAFT) Polymerization Using Continuous Flow Processing
Previous Article in Journal
Preparation and Characterization of the TiO2 Immobilized Polymeric Photocatalyst for Degradation of Aspirin under UV and Solar Light
Article Menu

Export Article

Open AccessArticle
Processes 2014, 2(1), 24-33; doi:10.3390/pr2010024

Rapid Determination of Optimal Conditions in a Continuous Flow Reactor Using Process Analytical Technology

Department of Chemistry, University of Washington, 4000 15th Ave NE, Seattle, WA 98105, USA
Applied Physics Laboratory, University of Washington, 1013 NE 40th Street, Seattle, WA 98105, USA
Tel-Tek, Kjølnes Ring 30, Porsgrunn 3918, Norway
Department of Chemistry, University of Bergen, P.O. Box 7800, Bergen NO-5020, Norway
Author to whom correspondence should be addressed.
Received: 5 November 2013 / Revised: 13 December 2013 / Accepted: 16 December 2013 / Published: 27 December 2013
View Full-Text   |   Download PDF [609 KB, uploaded 27 December 2013]   |  


Continuous flow reactors (CFRs) are an emerging technology that offer several advantages over traditional batch synthesis methods, including more efficient mixing schemes, rapid heat transfer, and increased user safety. Of particular interest to the specialty chemical and pharmaceutical manufacturing industries is the significantly improved reliability and product reproducibility over time. CFR reproducibility can be attributed to the reactors achieving and maintaining a steady state once all physical and chemical conditions have stabilized. This work describes the implementation of a smart CFR with univariate physical and multivariate chemical monitoring that allows for rapid determination of steady state, requiring less than one minute. Additionally, the use of process analytical technology further enabled a significant reduction in the time and cost associated with offline validation methods. The technology implemented for this study is chemistry and hardware agnostic, making this approach a viable means of optimizing the conditions of any CFR.
Keywords: continuous flow; Raman spectroscopy; process optimization continuous flow; Raman spectroscopy; process optimization
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Roberto, M.F.; Dearing, T.I.; Branham, C.W.; Bleie, O.; Marquardt, B.J. Rapid Determination of Optimal Conditions in a Continuous Flow Reactor Using Process Analytical Technology. Processes 2014, 2, 24-33.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Processes EISSN 2227-9717 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top