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Biomolecules 2015, 5(3), 1195-1209; doi:10.3390/biom5031195

New Insights into the Functions of Transcription Factors that Bind the RNA Polymerase Secondary Channel

Center for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, Baddiley-Clark Building, Richardson Road, Newcastle upon Tyne NE2 4AX, UK
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Academic Editors: Sivaramesh Wigneshweraraj and Deborah M. Hinton
Received: 17 March 2015 / Revised: 6 May 2015 / Accepted: 9 June 2015 / Published: 25 June 2015
(This article belongs to the Special Issue Bacterial RNA Polymerase)
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Abstract

Transcription elongation is regulated at several different levels, including control by various accessory transcription elongation factors. A distinct group of these factors interacts with the RNA polymerase secondary channel, an opening at the enzyme surface that leads to its active center. Despite investigation for several years, the activities and in vivo roles of some of these factors remain obscure. Here, we review the recent progress in understanding the functions of the secondary channel binding factors in bacteria. In particular, we highlight the surprising role of global regulator DksA in fidelity of RNA synthesis and the resolution of RNA polymerase traffic jams by the Gre factor. These findings indicate a potential link between transcription fidelity and collisions of the transcription and replication machineries. View Full-Text
Keywords: RNA polymerase; secondary channel; transcription factors; DksA; Gre; transcription fidelity; transcription processivity; transcription-replication conflicts RNA polymerase; secondary channel; transcription factors; DksA; Gre; transcription fidelity; transcription processivity; transcription-replication conflicts
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Zenkin, N.; Yuzenkova, Y. New Insights into the Functions of Transcription Factors that Bind the RNA Polymerase Secondary Channel. Biomolecules 2015, 5, 1195-1209.

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