Special Issue "Bacterial RNA Polymerase"


A special issue of Biomolecules (ISSN 2218-273X).

Deadline for manuscript submissions: closed (31 January 2015)

Special Issue Editors

Guest Editor
Prof. Dr. Sivaramesh Wigneshweraraj
Faculty of Medicine, MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London SW7 2AZ, UK
Website: http://www3.imperial.ac.uk/cmbi/researchgroups/sivarameshwigneshweraraj
E-Mail: s.r.wig@imperial.ac.uk
Interests: bacterial RNA polymerase; transcription regulation; bacteriophages; bacterial stress response; bacterial virulence gene expression and regulation

Guest Editor
Dr. Deborah M. Hinton
Gene Expression and Regulation Section, Laboratory of Cell and Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health, Bethesda, MD 20892, USA
Website: http://irp.nih.gov/pi/deborah-hinton
E-Mail: dhinton@helix.nih.gov
Interests: RNA polymerase; transcription initiation and activation; bacteriophage; bacterial virulence gene expression; response regulators

Special Issue Information

Dear Colleagues,

A single, large, and multi-subunit enzyme called RNA polymerase (RNAP) accomplishes all RNA syntheses in bacteria. Therefore, the bacterial RNAP represents a nexus for the regulation of bacterial gene expression and is frequently the target of sophisticated signal transduction pathways that serve to link environmental, metabolic and developmental cues to the regulation of gene expression at the transcriptional level. The bacterial RNAP is also a validated antibiotic target and is inhibited by the rifampicin-class of antibiotics. This Special Issue of Biomolecules contains invited reviews from leading scientists in the field on recent advances on the crystallographic, biochemical, single-molecule biophysical and systems level descriptions of the bacterial RNAP and on efforts to develop novel antibiotic-like compounds to inhibit this essential bacterial enzyme.

Prof. Dr. Sivaramesh Wigneshweraraj
Dr. Deborah M. Hinton
Guest Editors


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 600 CHF (Swiss Francs). English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.


  • RNA polymerase
  • transcription regulation
  • sigma factors
  • transcription regulators
  • promoters

Published Papers

No papers have been published in this special issue yet.

Last update: 6 August 2014

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