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Biomolecules 2015, 5(2), 1063-1078; doi:10.3390/biom5021063

Regulation of Transcription Elongation and Termination

1
Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY 10032, USA
2
Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA
*
Author to whom correspondence should be addressed.
Academic Editors: Deborah M. Hinton and Sivaramesh Wigneshweraraj
Received: 9 April 2015 / Revised: 20 May 2015 / Accepted: 21 May 2015 / Published: 29 May 2015
(This article belongs to the Special Issue Bacterial RNA Polymerase)
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Abstract

This article will review our current understanding of transcription elongation and termination in E. coli. We discuss why transcription elongation complexes pause at certain template sites and how auxiliary host and phage transcription factors affect elongation and termination. The connection between translation and transcription elongation is described. Finally we present an overview indicating where progress has been made and where it has not. View Full-Text
Keywords: transcription elongation; transcription pausing; transcription termination; Nus factors; transcription antitermination; transcription-translation coupling transcription elongation; transcription pausing; transcription termination; Nus factors; transcription antitermination; transcription-translation coupling
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Washburn, R.S.; Gottesman, M.E. Regulation of Transcription Elongation and Termination. Biomolecules 2015, 5, 1063-1078.

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