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Metabolites 2014, 4(2), 184-217; doi:10.3390/metabo4020184

Rationales and Approaches for Studying Metabolism in Eukaryotic Microalgae

Max Planck Institute of Molecular Plant Physiology, Am Muehlenberg 1, D-14476 Potsdam-Golm, Germany
Molecular Biotechnology & Systems Biology, Technical University of Kaiserslautern, Paul-Ehrlich-Str. 23, D-67663 Kaiserslautern, Germany
Author to whom correspondence should be addressed.
Received: 7 February 2014 / Revised: 23 March 2014 / Accepted: 25 March 2014 / Published: 11 April 2014
(This article belongs to the Collection Metabolism in Phototrophic Prokaryotes and Algae)
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The generation of efficient production strains is essential for the use of eukaryotic microalgae for biofuel production. Systems biology approaches including metabolite profiling on promising microalgal strains, will provide a better understanding of their metabolic networks, which is crucial for metabolic engineering efforts. Chlamydomonas reinhardtii represents a suited model system for this purpose. We give an overview to genetically amenable microalgal strains with the potential for biofuel production and provide a critical review of currently used protocols for metabolite profiling on Chlamydomonas. We provide our own experimental data to underpin the validity of the conclusions drawn.
Keywords: Chlamydomonas reinhardtii; metabolic engineering; biofuels; metabolite profiling; GC-MS; systems biology Chlamydomonas reinhardtii; metabolic engineering; biofuels; metabolite profiling; GC-MS; systems biology
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Veyel, D.; Erban, A.; Fehrle, I.; Kopka, J.; Schroda, M. Rationales and Approaches for Studying Metabolism in Eukaryotic Microalgae. Metabolites 2014, 4, 184-217.

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