Alternative Approach for Potency Assessment: In Vitro Methods
AbstractOver the last decade, incredible progress has been made in the development of non-animal tests to assess contact hypersensitivity. Four methods have been successfully validated and Organisation for Economic Co-operation and Development (OECD) guidelines are available or soon will be. Currently validated methods are useful for hazard identification, classification and labeling. However, to achieve a complete replacement of animals in skin sensitization assessment, dose-response information and evaluation of relative skin sensitizing potency to support effective risk assessment are necessary. In this context, potency is based on the concentration of chemicals needed to induce a positive response. This will require a better understanding of the mechanisms determining potency, including pathway analysis and marker signature identification (selection of an appropriate immune-mediated response to serve as the basis), together with quantitative and qualitative correlations between marker signatures and potency of chemicals in relation with T cell responses. This review aims to discuss the state-of-the-art in the field of in vitro assessment of the no induction sensitization level of contact sensitizers. View Full-Text
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Corsini, E.; Roggen, E.L.; Galbiati, V.; Gibbs, S. Alternative Approach for Potency Assessment: In Vitro Methods. Cosmetics 2016, 3, 7.
Corsini E, Roggen EL, Galbiati V, Gibbs S. Alternative Approach for Potency Assessment: In Vitro Methods. Cosmetics. 2016; 3(1):7.Chicago/Turabian Style
Corsini, Emanuela; Roggen, Erwin L.; Galbiati, Valentina; Gibbs, Sue. 2016. "Alternative Approach for Potency Assessment: In Vitro Methods." Cosmetics 3, no. 1: 7.
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