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Cosmetics 2016, 3(1), 7; doi:10.3390/cosmetics3010007

Alternative Approach for Potency Assessment: In Vitro Methods

1
Laboratory of Toxicology, DiSFeB, Università degli Studi di Milano, Milan 20133, Italy
2
3Rs Management and Consultancy, Kongens Lyngby 2800, Denmark
3
Department Oral Cell Biology, Academic Center for Dentistry Amsterdam, University of Amsterdam and VU University, Amsterdam 1081, The Netherlands
4
Department Dermatology, VU University Medical Centre, Amsterdam 1081, The Netherlands
*
Author to whom correspondence should be addressed.
Academic Editor: Enzo Berardesca
Received: 7 January 2016 / Revised: 17 February 2016 / Accepted: 22 February 2016 / Published: 25 February 2016
(This article belongs to the Special Issue Cosmetic Contact Allergens)
View Full-Text   |   Download PDF [379 KB, uploaded 25 February 2016]   |  

Abstract

Over the last decade, incredible progress has been made in the development of non-animal tests to assess contact hypersensitivity. Four methods have been successfully validated and Organisation for Economic Co-operation and Development (OECD) guidelines are available or soon will be. Currently validated methods are useful for hazard identification, classification and labeling. However, to achieve a complete replacement of animals in skin sensitization assessment, dose-response information and evaluation of relative skin sensitizing potency to support effective risk assessment are necessary. In this context, potency is based on the concentration of chemicals needed to induce a positive response. This will require a better understanding of the mechanisms determining potency, including pathway analysis and marker signature identification (selection of an appropriate immune-mediated response to serve as the basis), together with quantitative and qualitative correlations between marker signatures and potency of chemicals in relation with T cell responses. This review aims to discuss the state-of-the-art in the field of in vitro assessment of the no induction sensitization level of contact sensitizers. View Full-Text
Keywords: potency; allergy; keratinocytes; dendritic cells; in vitro immunotoxicology potency; allergy; keratinocytes; dendritic cells; in vitro immunotoxicology
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Corsini, E.; Roggen, E.L.; Galbiati, V.; Gibbs, S. Alternative Approach for Potency Assessment: In Vitro Methods. Cosmetics 2016, 3, 7.

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