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Cosmetics 2016, 3(1), 6; doi:10.3390/cosmetics3010006

Impact of Cosmetic Lotions on Nanoparticle Penetration through ex Vivo C57BL/6 Hairless Mouse and Human Skin: A Comparison Study

Department of Biomedical Engineering, University of Rochester, Rochester, NY 14642, USA
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
Department of Dermatology, University of Rochester Medical Center, Rochester, NY 14642, USA
Author to whom correspondence should be addressed.
Academic Editor: Enzo Berardesca
Received: 14 October 2015 / Revised: 5 February 2016 / Accepted: 14 February 2016 / Published: 19 February 2016
(This article belongs to the Special Issue Nanotechnologies in Cosmetics)
View Full-Text   |   Download PDF [3613 KB, uploaded 19 February 2016]   |  


Understanding the interactions of nanoparticles (NPs) with skin is important from a consumer and occupational health and safety perspective, as well as for the design of effective NP-based transdermal therapeutics. Despite intense efforts to elucidate the conditions that permit NP penetration, there remains a lack of translatable results from animal models to human skin. The objectives of this study are to investigate the impact of common skin lotions on NP penetration and to quantify penetration differences of quantum dot (QD) NPs between freshly excised human and mouse skin. QDs were mixed in seven different vehicles, including five commercial skin lotions. These were topically applied to skin using two exposure methods; a petri dish protocol and a Franz diffusion cell protocol. QD presence in the skin was quantified using Confocal Laser Scanning Microscopy. Results show that the commercial vehicles can significantly impact QD penetration in both mouse and human skin. Lotions that contain alpha hydroxyl acids (AHA) facilitated NP penetration. Lower QD signal was observed in skin studied using a Franz cell. Freshly excised human skin was also studied immediately after the sub-cutaneous fat removal process, then after 24 h rest ex vivo. Resting human skin 24 h prior to QD exposure significantly reduced epidermal presence. This study exemplifies how application vehicles, skin processing and the exposure protocol can affect QD penetration results and the conclusions that maybe drawn between skin models. View Full-Text
Keywords: nanoparticles; quantum dots; skin penetration; skin lotions nanoparticles; quantum dots; skin penetration; skin lotions

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Jatana, S.; Callahan, L.M.; Pentland, A.P.; DeLouise, L.A. Impact of Cosmetic Lotions on Nanoparticle Penetration through ex Vivo C57BL/6 Hairless Mouse and Human Skin: A Comparison Study. Cosmetics 2016, 3, 6.

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