Next Article in Journal
Rutin—Increased Antioxidant Activity and Skin Penetration by Nanocrystal Technology (smartCrystals)
Next Article in Special Issue
Can We Make Cosmetic Contact Allergy History?
Previous Article in Journal / Special Issue
Alternative Approach for Potency Assessment: In Vitro Methods
Article Menu

Export Article

Open AccessReview
Cosmetics 2016, 3(1), 8; doi:10.3390/cosmetics3010008

Mechanistic Understanding of Contact Allergy

Department of Dermatology, Medical Center, University of Freiburg, Hauptstrasse 7, 79104 Freiburg, Germany
Academic Editors: Emanuela Corsini and David Basketter
Received: 20 January 2016 / Revised: 16 February 2016 / Accepted: 22 February 2016 / Published: 25 February 2016
(This article belongs to the Special Issue Cosmetic Contact Allergens)
View Full-Text   |   Download PDF [460 KB, uploaded 25 February 2016]   |  

Abstract

Cosmetic products contain potential contact allergens or precursors that require metabolic conversion or oxidation to generate contact allergens. The most relevant contact allergens are fragrances and preservatives. These substances can pose hazards to human health due to their ability to activate T cells that can cause allergic contact dermatitis, an inflammatory skin disease. In recent years, much progress has been made in the elucidation of the mechanistic basis for immune system activation by contact allergens. This is essential for the development of better diagnostic tools, targeted therapies and animal-free in vitro assays for contact allergen identification. This overview will highlight some aspects of the activation of innate and adaptive immune responses by contact allergens. View Full-Text
Keywords: contact allergen; skin; innate immune response; heterologous innate immunity; biomarkers; therapy; in vitro assay; dendritic cell; T cell contact allergen; skin; innate immune response; heterologous innate immunity; biomarkers; therapy; in vitro assay; dendritic cell; T cell
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Martin, S.F. Mechanistic Understanding of Contact Allergy. Cosmetics 2016, 3, 8.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Cosmetics EISSN 2079-9284 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top