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Cosmetics 2016, 3(1), 8; doi:10.3390/cosmetics3010008

Mechanistic Understanding of Contact Allergy

Department of Dermatology, Medical Center, University of Freiburg, Hauptstrasse 7, 79104 Freiburg, Germany
Academic Editors: Emanuela Corsini and David Basketter
Received: 20 January 2016 / Revised: 16 February 2016 / Accepted: 22 February 2016 / Published: 25 February 2016
(This article belongs to the Special Issue Cosmetic Contact Allergens)
View Full-Text   |   Download PDF [460 KB, uploaded 25 February 2016]   |  


Cosmetic products contain potential contact allergens or precursors that require metabolic conversion or oxidation to generate contact allergens. The most relevant contact allergens are fragrances and preservatives. These substances can pose hazards to human health due to their ability to activate T cells that can cause allergic contact dermatitis, an inflammatory skin disease. In recent years, much progress has been made in the elucidation of the mechanistic basis for immune system activation by contact allergens. This is essential for the development of better diagnostic tools, targeted therapies and animal-free in vitro assays for contact allergen identification. This overview will highlight some aspects of the activation of innate and adaptive immune responses by contact allergens. View Full-Text
Keywords: contact allergen; skin; innate immune response; heterologous innate immunity; biomarkers; therapy; in vitro assay; dendritic cell; T cell contact allergen; skin; innate immune response; heterologous innate immunity; biomarkers; therapy; in vitro assay; dendritic cell; T cell

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Martin, S.F. Mechanistic Understanding of Contact Allergy. Cosmetics 2016, 3, 8.

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