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Cosmetics 2014, 1(3), 140-158; doi:10.3390/cosmetics1030140
Article

Chitin-Hyaluronan Nanoparticles: A Multifunctional Carrier to Deliver Anti-Aging Active Ingredients through the Skin

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Received: 14 May 2014; in revised form: 11 June 2014 / Accepted: 19 June 2014 / Published: 2 July 2014
(This article belongs to the Special Issue Selected Papers from ISBS/SICC 1st Joint International Congress)
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Abstract: The paper describes the process to produce Chitin Nanofibril-Hyaluronan nanoparticles (CN-HA), showing their ability to easily load active ingredients, facilitate penetration through the skin layers, and increase their effectiveness and safety as an anti-aging agent. Size and characterization of CN-HA nanoparticles were determined by Scanning Electron Microscopy (SEM) and Zetasizer, while encapsulation efficiency and loading capacity of the entrapped ingredients were controlled by chromatographic and spectrophotometric methods. Safeness was evidenced on fibroblasts and keratinocytes culture viability by the MTT (Methylthiazol) assay; anti-aging activity was evaluated in vitro measuring antioxidant capacity, anti-collagenase activity, and metalloproteinase and pro-inflammatory release; efficacy was shown in vivo by a double-blind vehicle-controlled study for 60 days on 60 women affected by photo-aging. In addition, the CN-HA nanoparticles have shown interesting possibility to be used as active ingredients, for designing and making advanced medication by the electrospinning technology, as well as to produce transparent films for food packaging, by the casting method, and can be used also in their dry form as tissues or films without adding preservatives. These unusual CN-HA nanoparticles obtained from the use of raw materials of waste origin may offer an unprecedented occasion for making innovative products, ameliorating the quality of life, reducing pollution and safeguarding the environment’s integrity.
Keywords: chitin nanofibrils; skin aging emulsions; innovative beauty masks; biopolymers; skin delivery; electrospinning; casting technology; fishery by-products; biomass waste chitin nanofibrils; skin aging emulsions; innovative beauty masks; biopolymers; skin delivery; electrospinning; casting technology; fishery by-products; biomass waste
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Morganti, P.; Palombo, M.; Tishchenko, G.; Yudin, V.E.; Guarneri, F.; Cardillo, M.; Del Ciotto, P.; Carezzi, F.; Morganti, G.; Fabrizi, G. Chitin-Hyaluronan Nanoparticles: A Multifunctional Carrier to Deliver Anti-Aging Active Ingredients through the Skin. Cosmetics 2014, 1, 140-158.

AMA Style

Morganti P, Palombo M, Tishchenko G, Yudin VE, Guarneri F, Cardillo M, Del Ciotto P, Carezzi F, Morganti G, Fabrizi G. Chitin-Hyaluronan Nanoparticles: A Multifunctional Carrier to Deliver Anti-Aging Active Ingredients through the Skin. Cosmetics. 2014; 1(3):140-158.

Chicago/Turabian Style

Morganti, Pierfrancesco; Palombo, Marco; Tishchenko, Galina; Yudin, Vladimir E.; Guarneri, Fabrizio; Cardillo, Maria; Del Ciotto, Paola; Carezzi, Francesco; Morganti, Gianluca; Fabrizi, Giuseppe. 2014. "Chitin-Hyaluronan Nanoparticles: A Multifunctional Carrier to Deliver Anti-Aging Active Ingredients through the Skin." Cosmetics 1, no. 3: 140-158.

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