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Cosmetics 2014, 1(2), 128-139; doi:10.3390/cosmetics1020128

Influence of Titanium Dioxide Particle Size on the Photostability of the Chemical UV-Filters Butyl Methoxy Dibenzoylmethane and Octocrylene in a Microemulsion

School of Pharmacy and Molecular Sciences, James Cook University, Townsville 4811, QLD, Australia
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Received: 8 May 2014 / Revised: 5 June 2014 / Accepted: 5 June 2014 / Published: 11 June 2014
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Abstract

Sunscreen products often contain combinations of ultraviolet (UV)-filters in order to achieve broad spectrum protection from exposure to sunlight. The inclusion of both chemical and physical UV-filters in these products, however, increases the possibility for both photolytic and photocatalytic reactions to occur. This study investigated the effect of titanium dioxide (TiO2) particle size on the photostability of the chemical UV-filters butyl methoxy dibenzoylmethane (BMDM) and octocrylene (OC) formulated in a microemulsion. The International Conference on Harmonisation (ICH) Guideline Q1B for photostability testing of new active substances and medicinal products was applied. BMDM and OC in the microemulsion were irradiated with simulated sunlight in the presence of nano- (<25 nm) and micro-TiO2 (~0.6 μm) and their concentrations determined using a validated high performance liquid chromatography (HPLC) method. For the combination of BMDM and OC, the photodegradation for BMDM was found to be 12% higher in the presence of nano-TiO2 as compared to that of the micro-TiO2. This enhanced photodegradation is attributed to the larger surface area of the nano-TiO2 and the increased generation of reactive oxygen species (ROS). Because of these findings, sunscreen products containing chemical UV-filters and nano-TiO2 should be regarded with caution, due to the potential loss of photoprotection.
Keywords: photostability; titanium dioxide; particle size; nano-TiO2; microemulsion; butyl methoxy dibenzoylmethane; octocrylene; high performance liquid chromatography (HPLC) photostability; titanium dioxide; particle size; nano-TiO2; microemulsion; butyl methoxy dibenzoylmethane; octocrylene; high performance liquid chromatography (HPLC)
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Kockler, J.; Oelgemöller, M.; Robertson, S.; Glass, B.D. Influence of Titanium Dioxide Particle Size on the Photostability of the Chemical UV-Filters Butyl Methoxy Dibenzoylmethane and Octocrylene in a Microemulsion. Cosmetics 2014, 1, 128-139.

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