Next Article in Journal
Ultra-Performance Liquid Chromatography Tandem Mass Spectrometry Measurement of Caffeine in Caffeine-Laced Pants and in Urine and Skin of a Pants User
Next Article in Special Issue
Evaluation of the Activity and Tolerability of a Cosmetic Treatment for the Periocular Area on the Aging Face: Controlled Clinical and Instrumental Evaluation vs. Placebo
Previous Article in Journal
Safety Evaluation of Cosmetic Ingredients: In Vitro Opportunities for the Identification of Contact Allergens
Previous Article in Special Issue
l-Ergothioneine Protects Skin Cells against UV-Induced Damage—A Preliminary Study
Cosmetics 2014, 1(2), 75-81; doi:10.3390/cosmetics1020075
Article

The Efficiency and Safety of Leuphasyl—A Botox-Like Peptide

, * ,
 and
Received: 19 December 2013; in revised form: 21 March 2014 / Accepted: 31 March 2014 / Published: 8 April 2014
(This article belongs to the Special Issue Selected Papers from ISBS/SICC 1st Joint International Congress)
View Full-Text   |   Download PDF [589 KB, uploaded 8 April 2014]   |   Browse Figures
Abstract: Peptides of synthesis are a very new strategy in cosmetic science and technology for at least two reasons: (1) they are small molecules, easily penetrable in the skin and (2) they are able to induce a very specific action, because all skin cells (keratinocytes, fibroblasts, nervous cells) have membrane receptors for peptides. This group of cosmeceutics includes the botox-like peptides, represented by acetyl hexapeptide 3 (Argireline) and pentapeptid-3 (Leuphasyl). The latter is less known and has been less studied. This substance inhibits the neuromuscular synapses in the mimic muscles, acting as enkephalins. It links the enkephalin receptor to nervous cells, thereby modulating the release of acetylcholine in synaptic space. This cellular activity will be translated in vivo in a relaxation of the muscle and a reduction of expression wrinkles. The aim of our study is to evaluate the optimal concentration of Leuphasyl for skin application at the mimic muscle level, the efficiency and the safety of this peptide. We formulated three emulsions of different concentrations (0.5%, 1%, 2%) which were applied to the skin, at the level of mimic muscles (1) at the eyebrows zone (above the corrugator supercilii muscle) and (2) at the periorbital zone (above the orbicularis oculi muscle). We evaluated the regression of the wrinkles between the eyebrows using an imagistic method: pro-derm Analyser. The study is of interest to discussions concerning how to apply these kinds of cosmetic products at the mimic muscle skin level and not at the level of the wrinkles.
Keywords: wrinkles; aging skin; botox-like peptides wrinkles; aging skin; botox-like peptides
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Dragomirescu, A.O.; Andoni, M.; Ionescu, D.; Andrei, F. The Efficiency and Safety of Leuphasyl—A Botox-Like Peptide. Cosmetics 2014, 1, 75-81.

AMA Style

Dragomirescu AO, Andoni M, Ionescu D, Andrei F. The Efficiency and Safety of Leuphasyl—A Botox-Like Peptide. Cosmetics. 2014; 1(2):75-81.

Chicago/Turabian Style

Dragomirescu, Anca O.; Andoni, Mihaiela; Ionescu, Daniela; Andrei, Felicia. 2014. "The Efficiency and Safety of Leuphasyl—A Botox-Like Peptide." Cosmetics 1, no. 2: 75-81.

Cosmetics EISSN 2079-9284 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert