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Cosmetics 2014, 1(1), 51-60; doi:10.3390/cosmetics1010051

l-Ergothioneine Protects Skin Cells against UV-Induced Damage—A Preliminary Study

1,†,* , 2,†, 1
1 Dr. Irena Eris Cosmetic Laboratories, Centre for Science and Research, Pulawska 107a, Warsaw 02-595, Poland 2 Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw and Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawinskiego 5a, Warsaw 02-106, Poland These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 31 December 2013 / Revised: 10 March 2014 / Accepted: 11 March 2014 / Published: 20 March 2014
(This article belongs to the Special Issue Selected Papers from ISBS/SICC 1st Joint International Congress)
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Many changes related to aging at the cellular level may be due to the physiological condition of mitochondria. One of the most common types of damage of mtDNA is the so-called “common deletion” referring to a deletion of 4977 base pairs. In the skin cells this phenomenon probably is caused by oxidative damage of mtDNA induced by UV. The present study was aimed at evaluating the effect of the antioxidant l-ergothioneine on UV-induced damage in skin cells. The effect of l-ergothioneine on the reduced glutathione level was studied. The presence of the “common deletion” in human fibroblasts irradiated with UVA and treated with l-ergothioneine was evaluated by a polymerase chain reaction. We have demonstrated that l-ergothioneine enhanced the level of reduced glutathione and protected cells from the induction of a photoaging-associated mtDNA “common deletion”. In view of our results, l-ergothioneine could be an effective skin care and anti-photoaging ingredient.
Keywords: l-ergothioneine; common deletion; mitochondria; photoaging l-ergothioneine; common deletion; mitochondria; photoaging
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Bazela, K.; Solyga-Zurek, A.; Debowska, R.; Rogiewicz, K.; Bartnik, E.; Eris, I. l-Ergothioneine Protects Skin Cells against UV-Induced Damage—A Preliminary Study. Cosmetics 2014, 1, 51-60.

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