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Low-Gain, Low-Noise Integrated Neuronal Amplifier for Implantable Artifact-Reduction Recording System
Department of Biomedical Engineering, Florida International University, Miami, FL, 33174, USA
University of Bordeaux, Laboratoire de l'Integration du Materiau au Systeme, UMR 5218, Talence, France
CNRS, Laboratoire de l'Integration du Materiau au Systeme, UMR 5218, Talence, France
University of Bordeaux, Institute of Neurodegenerative Diseases, UMR 5293, Bordeaux, France
* Author to whom correspondence should be addressed.
Received: 6 March 2013; in revised form: 8 July 2013 / Accepted: 6 August 2013 / Published: 9 September 2013
Abstract: Brain neuroprostheses for neuromodulation are being designed to monitor the neural activity of the brain in the vicinity of the region being stimulated using a single macro-electrode. Using a single macro-electrode, recent neuromodulation studies show that recording systems with a low gain neuronal amplifier and successive amplifier stages can reduce or reject stimulation artifacts. These systems were made with off-the-shelf components that are not amendable for future implant design. A low-gain, low-noise integrated neuronal amplifier (NA) with the capability of recording local field potentials (LFP) and spike activity is presented. In vitro and in vivo characterizations of the tissue/electrode interface, with equivalent impedance as an electrical model for recording in the LFP band using macro-electrodes for rodents, contribute to the NA design constraints. The NA occupies 0.15 mm2 and dissipates 6.73 µW, and was fabricated using a 0.35 µm CMOS process. Test-bench validation indicates that the NA provides a mid-band gain of 20 dB and achieves a low input-referred noise of 4 µVRMS. Ability of the NA to perform spike recording in test-bench experiments is presented. Additionally, an awake and freely moving rodent setup was used to illustrate the integrated NA ability to record LFPs, paving the pathway for future implantable systems for neuromodulation.
Keywords: low-noise amplifier; front-end; macro-electrode; neuralrecording; neuromodulation
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Zbrzeski, A.; Lewis, N.; Rummens, F.; Jung, R.; N'Kaoua, G.; Benazzouz, A.; Renaud, S. Low-Gain, Low-Noise Integrated Neuronal Amplifier for Implantable Artifact-Reduction Recording System. J. Low Power Electron. Appl. 2013, 3, 279-299.
Zbrzeski A, Lewis N, Rummens F, Jung R, N'Kaoua G, Benazzouz A, Renaud S. Low-Gain, Low-Noise Integrated Neuronal Amplifier for Implantable Artifact-Reduction Recording System. Journal of Low Power Electronics and Applications. 2013; 3(3):279-299.
Zbrzeski, Adeline; Lewis, Noëlle; Rummens, Francois; Jung, Ranu; N'Kaoua, Gilles; Benazzouz, Abdelhamid; Renaud, Sylvie. 2013. "Low-Gain, Low-Noise Integrated Neuronal Amplifier for Implantable Artifact-Reduction Recording System." J. Low Power Electron. Appl. 3, no. 3: 279-299.