Biology 2013, 2(1), 40-63; doi:10.3390/biology2010040
Review

BRCA1 and Its Network of Interacting Partners

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Received: 22 October 2012; in revised form: 26 November 2012 / Accepted: 20 December 2012 / Published: 2 January 2013
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: BRCA1 is a large multi-domain protein with a pivotal role in maintaining genome stability and cell cycle progression. Germline mutations in the BRCA1 gene confer an estimated lifetime risk of 60%–80% for breast cancer and 15%–60% for ovarian cancer. Many of the germline mutations associated with cancer development are concentrated in the amino terminal RING domain and the carboxyl terminal BRCT motifs of BRCA1, which are the most well-characterized regions of the protein. The function of BRCA1 in DNA repair, transcription and cell cycle control through the DNA damage response is orchestrated through its association with an impressive repertoire of protein complexes. The association of BRCA1 with ATM/ATR, CHK2 and Aurora A protein kinases regulates cell cycle progression, whilst its association with RAD51 has a direct impact on the repair of double strand DNA breaks (DSBs) by homologous recombination (HR). BRCA1 interactions with the MRN complex of proteins, with the BRCC complex of proteins that exhibit E3 ligase activity and with the phosphor proteins CtIP, BACH1 (BRIP1) and Abraxas (CCDC98) are also implicated in DNA repair mechanisms and cell cycle checkpoint control. BRCA1 through its association with specific proteins and multi-protein complexes is a sentinel of the normal cell cycle control and DNA repair.
Keywords: BRCA1; DNA repair damage response; HR; cell cycle checkpoint regulation; phosphorylation; E3 ligase; ubiquitination
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MDPI and ACS Style

Christou, C.M.; Kyriacou, K. BRCA1 and Its Network of Interacting Partners. Biology 2013, 2, 40-63.

AMA Style

Christou CM, Kyriacou K. BRCA1 and Its Network of Interacting Partners. Biology. 2013; 2(1):40-63.

Chicago/Turabian Style

Christou, Charita M.; Kyriacou, Kyriacos. 2013. "BRCA1 and Its Network of Interacting Partners." Biology 2, no. 1: 40-63.


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