Next Article in Journal
Acquired Class D β-Lactamases
Next Article in Special Issue
A Novel Organo-Selenium Bandage that Inhibits Biofilm Development in a Wound by Gram-Positive and Gram-Negative Wound Pathogens
Previous Article in Journal
Urinary Tract Infections
Previous Article in Special Issue
Bacteriophages and Biofilms
Antibiotics 2014, 3(3), 378-397; doi:10.3390/antibiotics3030378
Review

Foreign Body Infection Models to Study Host-Pathogen Response and Antimicrobial Tolerance of Bacterial Biofilm

1
, 2
 and 1,*
Received: 2 April 2014; in revised form: 1 July 2014 / Accepted: 6 August 2014 / Published: 21 August 2014
(This article belongs to the Special Issue Biofilm Infection)
Download PDF [1139 KB, uploaded 21 August 2014]
Abstract: The number of implanted medical devices is steadily increasing and has become an effective intervention improving life quality, but still carries the risk of infection. These infections are mainly caused by biofilm-forming staphylococci that are difficult to treat due to the decreased susceptibility to both antibiotics and host defense mechanisms. To understand the particular pathogenesis and treatment tolerance of implant-associated infection (IAI) animal models that closely resemble human disease are needed. Applications of the tissue cage and catheter abscess foreign body infection models in the mouse will be discussed herein. Both models allow the investigation of biofilm and virulence of various bacterial species and a comprehensive insight into the host response at the same time. They have also been proven to serve as very suitable tools to study the anti-adhesive and anti-infective efficacy of different biomaterial coatings. The tissue cage model can additionally be used to determine pharmacokinetics, efficacy and cytotoxicity of antimicrobial compounds as the tissue cage fluid can be aspirated repeatedly without the need to sacrifice the animal. Moreover, with the advance in innovative imaging systems in rodents, these models may offer new diagnostic measures of infection. In summary, animal foreign body infection models are important tools in the development of new antimicrobials against IAI and can help to elucidate the complex interactions between bacteria, the host immune system, and prosthetic materials.
Keywords: foreign body infection; mouse; staphylococcus; catheter abscess model; tissue cage model foreign body infection; mouse; staphylococcus; catheter abscess model; tissue cage model
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Nowakowska, J.; Landmann, R.; Khanna, N. Foreign Body Infection Models to Study Host-Pathogen Response and Antimicrobial Tolerance of Bacterial Biofilm. Antibiotics 2014, 3, 378-397.

AMA Style

Nowakowska J, Landmann R, Khanna N. Foreign Body Infection Models to Study Host-Pathogen Response and Antimicrobial Tolerance of Bacterial Biofilm. Antibiotics. 2014; 3(3):378-397.

Chicago/Turabian Style

Nowakowska, Justyna; Landmann, Regine; Khanna, Nina. 2014. "Foreign Body Infection Models to Study Host-Pathogen Response and Antimicrobial Tolerance of Bacterial Biofilm." Antibiotics 3, no. 3: 378-397.


Antibiotics EISSN 2079-6382 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert