Acquired Class D β-Lactamases
AbstractThe Class D β-lactamases have emerged as a prominent resistance mechanism against β-lactam antibiotics that previously had efficacy against infections caused by pathogenic bacteria, especially by Acinetobacter baumannii and the Enterobacteriaceae. The phenotypic and structural characteristics of these enzymes correlate to activities that are classified either as a narrow spectrum, an extended spectrum, or a carbapenemase spectrum. We focus on Class D β-lactamases that are carried on plasmids and, thus, present particular clinical concern. Following a historical perspective, the susceptibility and kinetics patterns of the important plasmid-encoded Class D β-lactamases and the mechanisms for mobilization of the chromosomal Class D β-lactamases are discussed.
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Antunes, N.T.; Fisher, J.F. Acquired Class D β-Lactamases. Antibiotics 2014, 3, 398-434.
Antunes NT, Fisher JF. Acquired Class D β-Lactamases. Antibiotics. 2014; 3(3):398-434.Chicago/Turabian Style
Antunes, Nuno T.; Fisher, Jed F. 2014. "Acquired Class D β-Lactamases." Antibiotics 3, no. 3: 398-434.