Next Article in Journal
Next Article in Special Issue
Previous Article in Journal
Previous Article in Special Issue
Antibiotics 2014, 3(3), 398-434; doi:10.3390/antibiotics3030398
Review

Acquired Class D β-Lactamases

*  and
Received: 3 June 2014; in revised form: 31 July 2014 / Accepted: 8 August 2014 / Published: 21 August 2014
(This article belongs to the Special Issue Mechanisms of Antibiotic Resistance)
View Full-Text   |   Download PDF [1233 KB, updated 22 August 2014; original version uploaded 21 August 2014]   |   Browse Figure
Abstract: The Class D β-lactamases have emerged as a prominent resistance mechanism against β-lactam antibiotics that previously had efficacy against infections caused by pathogenic bacteria, especially by Acinetobacter baumannii and the Enterobacteriaceae. The phenotypic and structural characteristics of these enzymes correlate to activities that are classified either as a narrow spectrum, an extended spectrum, or a carbapenemase spectrum. We focus on Class D β-lactamases that are carried on plasmids and, thus, present particular clinical concern. Following a historical perspective, the susceptibility and kinetics patterns of the important plasmid-encoded Class D β-lactamases and the mechanisms for mobilization of the chromosomal Class D β-lactamases are discussed.
Keywords: OXA; β-lactamase; plasmid; class D; carbapenemase; kinetics; crystal structure OXA; β-lactamase; plasmid; class D; carbapenemase; kinetics; crystal structure
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Antunes, N.T.; Fisher, J.F. Acquired Class D β-Lactamases. Antibiotics 2014, 3, 398-434.

AMA Style

Antunes NT, Fisher JF. Acquired Class D β-Lactamases. Antibiotics. 2014; 3(3):398-434.

Chicago/Turabian Style

Antunes, Nuno T.; Fisher, Jed F. 2014. "Acquired Class D β-Lactamases." Antibiotics 3, no. 3: 398-434.

Antibiotics EISSN 2079-6382 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert